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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:19 AM EST

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Showing 97–120 of 127 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: gum chewing Clear all

Conditions: Cigarette Smoker
Interventions: nicotine polacrilex, nicotine transdermal system, nicotine inhaler; Drug
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Smoking Behaviors
Interventions: Participants will place the pouch between their top lip and their gum for 30 minutes as per use instructions.; Drug
Lead sponsor: JT International SA; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 2
States / cities: Knoxville, Tennessee • San Antonio, Texas

Conditions: Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Persistent Depressive Disorder
Interventions: Quit on the Go App (formerly "Learn to Quit " App), Brief advice, Nicotine patch, Smartphone coaching, Nicotine gum, Nicotine Lozenges; Device · Behavioral · Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 343 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 3
States / cities: Buffalo, New York • Durham, North Carolina • Winston-Salem, North Carolina

Conditions: PTSD, Smoking
Interventions: Bupropion, nicotine replacement therapy, Smoking cessation counseling, mobile contingency management, Stay Quit Coach; Drug · Other · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: End Stage Renal Disease
Interventions: Chitosan; Dietary Supplement
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 64 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Schizophrenia, Cigarette Smoking
Interventions: Nicotine replacement therapy, Bupropion, cognitive-behavioral smoking cessation counseling, Mobile Contingency Management, Stay Quit Coach, SMS text messaging; Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Return of Bowel Function Following Spinal Surgery
Interventions: Chewing gum; Dietary Supplement
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 90 Years
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Cigarette Smoking, Veterans
Interventions: Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling, Healthy Changes Counseling; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking, Smoking Cessation
Interventions: Nicotine patch, Nicotine gum, CMAC; Drug · Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 987 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 2
States / cities: Seattle, Washington • Madison, Wisconsin

Conditions: Irritable Bowel Syndrome
Interventions: Diet A - elimination diet, Diet B - healthy eating diet; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 65 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Orthodontic Appliances
Interventions: Xylitol Gum; Drug
Lead sponsor: West Virginia University; Other
Eligibility: Up to 18 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Interventions: Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine, Electronic Cigarette with no nicotine, Moist snuff, Sham Smoking, Secondhand cigarette smoke (SHS), Conditioned, filtered air, Sham Moist Snuff; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 50 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2021
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking Cessation
Interventions: WeChat Quit Coach, Leaflet, Optional Nicotine Replacement Therapy (NRT) Patches or Lozenges; Behavioral · Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 80 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking, Smoking Cessation, Motivation, Nicotine Dependence
Interventions: Nicotine Patch, Nicotine Gum, Motivational Interviewing, Smoking Reduction, No Intervention, Nicotine Patch + Nicotine Gum; Drug · Behavioral · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 517 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Obesity
Interventions: Chewing gum, Water; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 38 Years · Female only
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Cigarette Smoking
Interventions: Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral, Nicotine replacement therapy - nicotine gum, Nicotine replacement therapy - nicotine lozenge, Bupropion Sustained Release, Varenicline, Combination pharmacotherapy - transdermal nicotine patch + nicotine gum, Combination pharmacotherapy - transdermal nicotine patch + nicotine lozenge, Combination pharmacotherapy - transdermal nicotine patch + bupropion, Alcohol use risk reduction, Behavioral activation for the treatment of depression, Behavioral management of post-cessation weight gain; Drug · Behavioral
Lead sponsor: Iowa City Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 99 Years
Enrollment: 63 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: SARS-CoV-2
Interventions: ACE2 Chewing Gum, Placebo Chewing Gum; Drug · Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation, Cancer, Treatment-Related
Interventions: Varenicline, Bupropion, Long-acting nicotine replacement therapy, Low-intensity counseling, High-intensity counseling, No nicotine replacement therapy, Nicotine Replacement Products; Drug · Behavioral · Other
Lead sponsor: Joseph Valentino, MD; Other
Eligibility: 18 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 3
States / cities: Bowling Green, Kentucky • Lexington, Kentucky • Owensboro, Kentucky

Conditions: Tobacco Use Disorder
Interventions: Nicotine polacrilex, Bupropion; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 50 Years and older
Enrollment: 403 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Colon Resection
Interventions: gum chewing, no gum chewing; Other
Lead sponsor: Allina Health System; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Saint Paul, Minnesota

Conditions: Cigarette Smoking Behavior, E-Cigarette Use
Interventions: E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms, Cessation counseling; Other · Drug · Behavioral
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 21 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation
Interventions: Nicotine patch, Nicotine gum, Medication Therapy Management; Drug · Behavioral
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Tinnitus, Chronic Subjective Tinnitus
Interventions: Nicotine polacrilex gum 4 mg, Placebo gum; Drug · Other
Lead sponsor: San Diego State University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: San Diego, California

Conditions: Ileus
Interventions: chewing gum - Extra Winterfresh, Standard Post-Op Care; Other
Lead sponsor: Aultman Health Foundation; Other
Eligibility: 18 Years and older · Female only
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Canton, Ohio

Search by objective public record fields.

Validation of Biomarkers of Exposure and Host Response

Nicotine Pouch Pharmacokinetics Abuse Liability

Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings

Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD

Chitosan Chewing Gum Study in Dialysis Patients

Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia

Does Chewing Gum Hasten Return of Bowel Function Post-Operatively in Patients Undergoing Spinal Surgery

Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment

Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines

Defining Objective Markers of Compliance for Dietary Therapies in IBS

Orthodontic Pain Alleviation With Chewing Gum

Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products

WeChat Quit Coach Pilot Study

Identifying Treatments to Motivate Smokers to Quit

The Effects of Gum Chewing on Energy Intake and Expenditure

Tailored Tobacco Quitline for Rural Veterans

ACE2 Chewing Gum on SARS-CoV-2 Viral Load (COVID 19)

Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment

Maintaining Nonsmoking: Older Smokers - 1

The Effect of Gum Chewing on Bowel Motility in Post-operative Colon Resection Patients

Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.

QuitAid Pilot Feasibility Trial

Acute Nicotine Gum and Tinnitus Loudness in Non-Smoking Adults

Prevention of Ileus After Gynecologic Surgery Using Chewing Gum