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ClinicalTrials.gov public records Last synced Sep 25, 2026, 12:21 AM EDT

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Showing 1–24 of 55 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: high-definition transcranial direct current stimulation Clear all
Recruiting Not applicable Interventional

Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways

NCT07469384
View directory record Official record
Conditions
SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder
Interventions
transcranial direct current stimulation, Sham stimulation
Device
Lead sponsor
Nathan Kline Institute for Psychiatric Research
Other
Eligibility
18 Years to 55 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Orangeburg, New York
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

tDCS for Cancer-Related Fatigue and Weakness

NCT07159100
View directory record Official record
Conditions
Cancer-related Fatigue, Neuromodulation
Interventions
Active tDCS + elbow flexion exercise, Sham tDCS + elbow flexion exercise
Device · Drug
Lead sponsor
Kessler Foundation
Other
Eligibility
40 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Sep 25, 2026, 12:21 AM EDT
Completed Not applicable Interventional

Exploration of Parameters of Transcranial Direct Current Stimulation (tDCS) in Chronic Pain

NCT01402960
View directory record Official record
Conditions
Chronic Pain
Interventions
High Definition Transcranial Direct Current Stimulation (HD-tDCS)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 25, 2026, 12:21 AM EDT
Completed Phase 2 Interventional

Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS

NCT04046991
View directory record Official record
Conditions
Primary Progressive Aphasia
Interventions
high-definition transcranial direct current stimulation, modified constraint-induced language therapy
Device · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Sep 25, 2026, 12:21 AM EDT
Recruiting Not applicable Interventional

Testing Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) as a Treatment of Posterior Cortical Atrophy

NCT07191327
View directory record Official record
Conditions
Posterior Cortical Atrophy
Interventions
HD-tDCS sessions, Sham HD-tDCS sessions, HD-tDCS sessions - Open-label (after randomized treatment)
Device
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

NCT03887481
View directory record Official record
Conditions
Logopenic Progressive Aphasia, Primary Progressive Aphasia
Interventions
High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Terminated Not applicable Interventional

Transcranial Direct Current Stimulation (tDCS) in Post-Stroke Working Memory Deficits

NCT03034109
View directory record Official record
Conditions
Stroke, Cognitive Deficit, Cognitive Impairment, Short-Term Memory Impairment
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 22, 2017 · Synced Sep 25, 2026, 12:21 AM EDT
Recruiting Not applicable Interventional

Open-label Feasibility Trial of HD-tDCS During Cognitive Behavioral Therapy for Cocaine Use Disorder

NCT07829263
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
High Definition Transcranial Direct Current Stimulation
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Recruiting Not applicable Interventional

Low Voltage Electrical Stimulation for Depression in Parkinson's Patients

NCT06467695
View directory record Official record
Conditions
Parkinson Disease, Depressive Symptoms
Interventions
BIOPAC Stimsola, BIOPAC Stimsola Sham (zero amps)
Device
Lead sponsor
University of South Alabama
Other
Eligibility
19 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Mobile, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Withdrawn Not applicable Interventional

Investigating HD-tDCS in Improving Word Finding and Memory Retrieval in Individuals With MCI

NCT03446508
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Active frontal, Active parietal, Sham
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
40 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2022 · Synced Sep 25, 2026, 12:21 AM EDT
Completed Not applicable Interventional

Single-arm, Open-label, Phase II Trial of HD-tDCS in Fibromyalgia Patients

NCT01842009
View directory record Official record
Conditions
Fibromyalgia, Chronic Pain
Interventions
High Definition transcranial Direct Current Stimulation
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 25, 2026, 12:21 AM EDT
Withdrawn Not applicable Interventional

Modulating Context Generalization Through Transcranial Direct Current Stimulation

NCT03374605
View directory record Official record
Conditions
Anxiety and Fear
Interventions
active tDCS, sham tDCS
Device
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 6, 2018 · Synced Sep 25, 2026, 12:21 AM EDT
Completed Not applicable Interventional

MRI Study of High Definition Transcranial Electrical Stimulation in Chronic Tinnitus (MRI HDtES-T)

NCT05120037
View directory record Official record
Conditions
Tinnitus, Subjective
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Sep 25, 2026, 12:21 AM EDT
Completed No phase listed Observational

Targeted Noninvasive Brain Stimulation to Improve Hand Dexterity in Stroke Patients

NCT04058288
View directory record Official record
Conditions
Stroke
Interventions
High-definition Transcranial Direct Current Stimulation
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 11, 2023 · Synced Sep 25, 2026, 12:21 AM EDT
Recruiting Not applicable Interventional

Treating Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation

NCT04869059
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Transcranial direct current stimulation, sham tDCS
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 75 Years
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Sep 25, 2026, 12:21 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Psychobiological Responses Following Exercise and Brain Stimulation

NCT06874595
View directory record Official record
Conditions
Psychological
Interventions
Cycling exercise at 65% of HRR for 20 minutes followed by HD-tDCS (exercise + HD-tDCS), Cycling exercise at 65% of HRR exercise followed by sham HD-tDCS (exercise + sham tDCS), No exercise followed by HD-tDCS (no exercise + HD-tDCS)., State Anxiety Inventory, Visual Analog Scale for Anxiety
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 50 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Completed Not applicable Interventional Results available

Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)

NCT05408975
View directory record Official record
Conditions
Traumatic Brain Injury, Word Finding Difficulty, Acquired Brain Injury, Cognitive Change
Interventions
Active Transcranial direct current stimulation, Sham Transcranial direct current stimulation
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Completed Not applicable Interventional

Transcranial Direct Current Stimulation (tDCS) Therapy in Major Depression

NCT04507243
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active - HD tDCS, Sham - HD tDCS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Sep 25, 2026, 12:21 AM EDT
Active, not recruiting Not applicable Interventional

Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation

NCT05368350
View directory record Official record
Conditions
Primary Progressive Aphasia, Apraxia of Speech
Interventions
high-definition transcranial direct current stimulation (HD-tDCS)
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Completed Not applicable Interventional Results available

Targeted High-definition Transcranial Direct Current Stimulation (HD-tDCS) for Reducing Post-stroke Movement Impairments

NCT05174949
View directory record Official record
Conditions
Stroke
Interventions
Transcranial direct current stimulation (high-definition)
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 90 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Sep 25, 2026, 12:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome

NCT02481765
View directory record Official record
Conditions
Down Syndrome
Interventions
High definition transcranial direct current stimulation
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 45 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Sep 25, 2026, 12:21 AM EDT
Recruiting Not applicable Interventional

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)

NCT05769348
View directory record Official record
Conditions
Chronic Migraine
Interventions
HD-tDCS Active Protocol, HD-tDCS Sham Protocol
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Active, not recruiting Not applicable Interventional

Targeted HD-tDCS to Improve Upper Limb Rehabilitation in SCI

NCT05589415
View directory record Official record
Conditions
Spinal Cord Injuries, Spinal Cord Diseases
Interventions
High-definition Transcranial Direct Current Stimulation, Conventional Transcranial Direct Current Stimulation
Device
Lead sponsor
University of Texas Rio Grande Valley
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Harlingen, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 25, 2026, 12:21 AM EDT
Recruiting Not applicable Interventional

Using Non-invasive Brain Stimulation to Explore Potential Treatments to Reduce Speech Errors in Adults Who Stutter

NCT07354139
View directory record Official record
Conditions
Stuttering, Fluency Disorder
Interventions
High - Definition Transcranial Direct Current Stimulation
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 25, 2026, 12:21 AM EDT