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ClinicalTrials.gov public records Last synced Oct 18, 2026, 12:34 PM EDT

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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: hypocaloric diet Clear all
Completed Not applicable Interventional Results available

ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)

NCT03651622
View directory record Official record
Conditions
Diabetes Mellitus, Type 1, Overweight and Obesity
Interventions
Hypocaloric, low carbohydrate diet, Hypocaloric, moderate low fat diet, Mediterranean diet, no caloric restriction
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
19 Years to 30 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Palo Alto, California • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 4, 2022 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Phase 1Phase 2 Interventional

Use of MCT Oil for Enhancement of Weight Loss and Glycemic Control in Obese Diabetic Patients

NCT00207233
View directory record Official record
Conditions
Obesity, Type 2 Diabetes Mellitus
Interventions
MCT oil hypocaloric liquid diet, LCT hypocaloric liquid diet, Subcutaneous abdominal adipose tissue biopsy
Behavioral · Procedure
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 25, 2011 · Synced Oct 18, 2026, 12:34 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Efficacy of a Structured Weight Loss Program in Overweight Women With a History of Recurrent Pregnancy Loss

NCT01325805
View directory record Official record
Conditions
Obese, Overweight, Miscarriage, Recurrent Pregnancy Loss
Interventions
Structured Weight Loss Program, Routine Weight Loss Counseling
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 39 Years · Female only
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 3, 2022 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Weight Loss and Cognitive Function in Adults

NCT03685305
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Hypocaloric diet with hunger reduction strategy, Hypocaloric diet without hunger reduction strategy
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
50 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 21, 2025 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional Results available

Exercise Intolerance in Elderly Patients With Diastolic Heart Failure

NCT00959660
View directory record Official record
Conditions
Heart Failure, Diastolic, Obesity
Interventions
Exercise, Dietary Intervention, Diet and exercise, Attention Control
Behavioral · Dietary Supplement · Other
Lead sponsor
Wake Forest University
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 15, 2019 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Phase 2 Interventional Results available

Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid

NCT03648996
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Hyperuricemia
Interventions
Low-fructose diet, isocaloric, Allopurinol, Placebo, Low-fructose, hypocaloric
Other · Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
40 Years to 75 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional

Noninvasive Neuromodulation of the Prefrontal Cortex in Subjects With Obesity

NCT02953353
View directory record Official record
Conditions
Obesity
Interventions
Active transcranial direct current stimulation (tDCS), Hypocaloric diet, Sham transcranial direct current stimulation (tDCS)
Device · Other
Lead sponsor
University of Sao Paulo
Other
Eligibility
20 Years to 40 Years · Female only
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2021 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Aging, Lifestyle and Inflammation in Veterans Exercising

NCT00667030
View directory record Official record
Conditions
Inflammation, Aging, Metabolism, Exercise
Interventions
Weight loss and aerobic exercise training
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional

Use of MCT Oil for Enhancement of Weight Loss in Obese Patients

NCT00207272
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
1170-1870 kcal/day liquid diet, Gastric bypass surgery, Biopsy.visceral adipose tissue, Biopsy.omental adipose tissue, Biopsy. subcutaneous abdominal adipose tissue, Blood sample
Behavioral · Procedure
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 26, 2008 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Food Reinforcement During Obesity Treatment

NCT00200291
View directory record Official record
Conditions
Obesity
Interventions
hypocaloric, low-fat diet
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
21 Years to 70 Years · Female only
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 20, 2012 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Changing Dietary Fat on Weight Loss

NCT02953158
View directory record Official record
Conditions
Overweight
Interventions
Haas Avocado, Dietary Counseling
Other · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
20 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 2, 2020 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional

Bariatric Surgery And Adipose Inflammation Dysfunction and Type 2 Diabetes Mellitus

NCT01882036
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Insulin Resistance
Interventions
Gastric Bypass w/ matched hypocaloric diet, Hypocaloric diet
Procedure · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Diet and Whole-body Vibration Training on Cardiovascular and Autonomic Function

NCT01741779
View directory record Official record
Conditions
Obesity, Pre-hypertension, Hypertension
Interventions
Whole Body Vibration Training, Hypocaloric diet, Whole body vibration training & diet
Other
Lead sponsor
Florida State University
Other
Eligibility
45 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Dec 5, 2012 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Not applicable Interventional Results available

Exercise Intolerance in Elderly Patients With HFpEF(Heart Failure With Preserved Ejection Fraction)

NCT02636439
View directory record Official record
Conditions
Heart Failure, Diastolic, Obesity
Interventions
dietary, aerobic and resistance training, dietary, and aerobic exercise
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 15, 2022 · Synced Oct 18, 2026, 12:34 PM EDT
Not listed Not applicable Interventional

Effect of Modified Time-restricted Feeding in Preventing Progression of Non-Alcoholic Fatty Liver Disease (NAFLD).

NCT03848390
View directory record Official record
Conditions
Non-Alcoholic Fatty Liver Disease
Interventions
Conventional diet, Modified Time-restricted Feeding, Physical activity, Restricted consumption of sweetened beverages
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
8 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 15, 2019 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Phase 4 Interventional

Improving Beta Cell Function in Mexican American Women With Prediabetes

NCT02488057
View directory record Official record
Conditions
Pre-Diabetes
Interventions
Liraglutide, Weight loss
Drug · Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Los Angeles, California • Torrance, California • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Phase 2Phase 3 Interventional

Effects of Intentional Weight Loss Interventions in Chronic Kidney Disease

NCT01180101
View directory record Official record
Conditions
Chronic Kidney Disease, Obesity
Interventions
Diet and exercise, Bariatric Surgery
Behavioral · Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
19 Years to 99 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Phase 4 Interventional

A Phase IV, Multi-Center, Open-Label Trial of Sibutramine in Combination With a Hypocaloric Diet in Obese and Overweight Thai Subjects.

NCT00234988
View directory record Official record
Conditions
Obesity
Interventions
sibutramine hydochloride monohydrate
Drug
Lead sponsor
Abbott
Industry
Eligibility
18 Years to 65 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
North Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 15, 2008 · Synced Oct 18, 2026, 12:34 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Water Intake and Weight Control in Older Adults

NCT05843318
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Water intake and weight control in older adults - Premeal Water + hypocaloric diet, Water intake and weight control in older adults - Total Daily Water + hypocaloric diet, Water Intake and weight control in older adults - hypocaloric diet alone
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
50 Years and older
Enrollment
375 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 18, 2026, 12:34 PM EDT
Recruiting Not applicable Interventional

Role of Race in Nutritional Approach in Men on ADT

NCT06682390
View directory record Official record
Conditions
Prostate Cancer Metastatic Disease
Interventions
Hypocaloric anti-inflammatory diet
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Male only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 18, 2026, 12:34 PM EDT
Terminated Phase 2 Interventional

Effects of Caloric Restriction Alone Versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients With Diabetes Mellitus

NCT01083108
View directory record Official record
Conditions
Obesity, Bariatric Surgery, Morbid Obesity, Diabetes Mellitus Type 2, Diet Therapy
Interventions
Roux-en-Y Gastric Bypass, Caloric Restriction
Other
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 60 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
3
States / cities
Baltimore, Maryland • Bethesda, Maryland • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Phase 3 Interventional

VIsceral Fat Reduction Assessed by CT-scan On RImonabAnt

NCT00299325
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
Rimonabant, Placebo (for Rimonabant), Mild hypocaloric diet
Drug · Other
Lead sponsor
Sanofi
Industry
Eligibility
35 Years to 70 Years
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 6, 2016 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Weight Loss With Exenatide Treatment

NCT01590433
View directory record Official record
Conditions
Obesity
Interventions
Exenatide, Placebo, Dietary counseling
Drug · Behavioral
Lead sponsor
Jody Dushay
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
249 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced Oct 18, 2026, 12:34 PM EDT
Completed Phase 4 Interventional Results available

Cardiovascular Effects of GLP-1 Receptor Activation

NCT03101930
View directory record Official record
Conditions
Obesity, PreDiabetes
Interventions
Liraglutide, Sitagliptin, hypocaloric diet, Placebos, Exendin (9-39)
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Oct 18, 2026, 12:34 PM EDT