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Conditions: Posttraumatic Stress Disorder
Interventions: Prolonged Exposure Therapy for Posttraumatic Stress Disorder; Behavioral
Lead sponsor: VA Boston Healthcare System; Federal
Eligibility: 18 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Social Anxiety Disorder
Interventions: Transdiagnostic Behavior Therapy, Cognitive Behavioral Therapy for Social Anxiety Disorder; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 264 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Social Anxiety Disorder (Social Phobia), Public Speaking Anxiety, Anhedonia, ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Phobic Disorders
Interventions: Positive Affect Treatment - Behavioral (PAT-B), Relaxation Treatment, Exposure Therapy; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 60 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Post Traumatic Stress Disorder
Interventions: Prolonged Exposure; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Stress Disorders, Post-Traumatic Stress Disorder
Interventions: Prolonged Exposure Therapy (PE), Virtual Reality Exposure Therapy (VRET), Waitlist; Behavioral
Lead sponsor: National Center for Telehealth and Technology; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Fort Bragg, North Carolina

Conditions: Depression, Anxiety
Interventions: Positive Affect Treatment, Positive Affect Treatment and Negative Affect Treatment; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Los Angeles, California • Dallas, Texas

Conditions: PTSD
Interventions: written exposure therapy, CPT, cognitive only; Behavioral
Lead sponsor: Boston VA Research Institute, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 169 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2021
U.S. locations: 2
States / cities: Killeen, Texas • San Antonio, Texas

Conditions: Anhedonia, Depression in Adults, Anxiety
Interventions: Positive Affect Treatment; Behavioral
Lead sponsor: Southern Methodist University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Stress Disorders, Post-Traumatic
Interventions: Adjunctive writing to amplify response and engagement (AWARE), Cognitive processing therapy (CPT), Prolonged exposure (PE); Behavioral
Lead sponsor: Boston University; Other
Eligibility: 18 Years and older
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: PTSD
Interventions: psilocybin, Supportive Therapy, Prolonged Exposure Therapy; Drug · Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: PTSD
Interventions: Extended Training in Prolonged Exposure Therapy for PTSD, Standard Training in Prolonged Exposure Therapy for PTSD; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2021
U.S. locations: 3
States / cities: Colorado Springs, Colorado • Fort Campbell North, Kentucky • El Paso, Texas

Conditions: Post-traumatic Stress Disorder (PTSD)
Interventions: Accelerated Resolution Therapy (ART); Behavioral
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years and older
Enrollment: 155 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 8
States / cities: Clearwater, Florida • Holiday, Florida • Jupiter, Florida + 5 more

Conditions: PTSD, Post Traumatic Stress Disorder
Interventions: Traditional Exposure Therapy (ET) Treatment, Stepwise Augmented Reality (AR) Component with Traditional Exposure Treatment for Nonresponders; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: PTSD
Interventions: trauma-focused treatment; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 3
States / cities: Boston, Massachusetts • Charleston, South Carolina • Madison, Wisconsin

Conditions: Post Traumatic Stress Disorder, Opioid-use Disorder
Interventions: Prolonged Exposure Therapy, Attendance-based monetary incentives; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Trauma, Posttraumatic Stress Disorder
Interventions: Personalized Stepped Care Cognitive Behavioral Therapy for Children after Trauma (pSC-CBT-CT); Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 7 Years to 14 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: PTSD, Suicidal Ideation, Suicide, Attempted, Trauma, Psychological
Interventions: Prolonged exposure; Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Osteo Arthritis Knee
Interventions: Cognitive-Behavioral Intervention, Pain Education; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 45 Years to 85 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Posttraumatic Stress Disorder, Combat Disorder
Interventions: 60-minute Prolonged Exposure Therapy, 90-minute Prolonged Exposure Therapy; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2021
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Posttraumatic Stress Disorder
Interventions: imaginal therapy, exercise, self-care; Behavioral
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Fort Hood, Texas

Conditions: Posttraumatic Stress Disorder
Interventions: DCS, Placebo; Drug · Other
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Posttraumatic Stress Disorder, Spinal Cord Injuries
Interventions: Prolonged Exposure Therapy; Behavioral
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2026
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Posttraumatic Stress Disorder, PTSD
Interventions: Modular Cognitive Processing Therapy, Modular Prolonged Exposure Therapy, Step Down Treatment, Digital Interventions, Cognitive Processing Therapy (CPT), Prolonged Exposure (PE); Behavioral
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 4
States / cities: Augusta, Georgia • Ann Arbor, Michigan • Battle Creek, Michigan + 1 more

Conditions: Substance Use Disorder, Posttraumatic Stress Disorder
Interventions: Prolonged Exposure with Contingency Management, Standard Care; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 25 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 3
States / cities: Farmington, Connecticut • Hartford, Connecticut • New Britain, Connecticut

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Mechanisms Underlying the Efficacy of Prolonged Exposure

Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder

Reward Processing and Exposure Therapy for Social Anxiety Disorder

Mechanisms Underlying Efficacy of Prolonged Exposure

Comparing Virtual Reality Exposure Therapy to Prolonged Exposure

Affect Treatment for Depression and Anxiety (TAD Pilot)

Brief Treatment for Posttraumatic Stress Disorder

Positive Affect Treatment for Spanish-Speaking Individuals

Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication

Psilocybin-Assisted Therapy

Implementation of Prolonged Exposure in the Military

Prospective Cohort Study of Accelerated Resolution Therapy (ART) for Treatment of Military Psychological Trauma

Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

Written Exposure Therapy Versus Prolonged Exposure: a Non-inferiority Trial

Prolonged Exposure Therapy for PTSD and Opioid Use Disorder

Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (Pilot)

Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD

Study of Pain Catastrophizing

The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD

The Role of Exercise in the Treatment of PTSD Symptoms

Imaginal Exposure & D-Cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)

Outcomes After Spinal Cord Injury (OASIS)

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults