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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: interoceptive exposure Clear all
Withdrawn Not applicable Interventional

A Comparison of Treatment Rationales on Willingness to Tolerate Distress in Interoceptive Exposure

NCT04259190
View directory record Official record
Conditions
Anxiety Sensitivity
Interventions
interoceptive exposure
Behavioral
Lead sponsor
Gina Boullion
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
University, Mississippi
Source: ClinicalTrials.gov public record
Updated Jun 25, 2020 · Synced Sep 5, 2026, 2:08 AM EDT
Not listed Not applicable Interventional

Augmented Interoceptive Exposure Training in Anorexia Nervosa

NCT03019081
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Isoproterenol, placebo
Drug · Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 40 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 4, 2023 · Synced Sep 5, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Interoceptive Training Enhanced Mindfulness

NCT06786572
View directory record Official record
Conditions
Anxiety Sensitivity
Interventions
Mindfulness training, Interoceptive exposure
Other · Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Outcomes of a Self-guided Versus Therapist-guided Online Mental Health Treatment

NCT04810988
View directory record Official record
Conditions
Depression, Anxiety, Mood
Interventions
Unified Protocol, Therapist Support
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2024 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Phase 2 Interventional

Development of an Anxiety Sensitivity-Based Intervention for Substance Use and Anxiety Comorbidity

NCT02667015
View directory record Official record
Conditions
Other (or Unknown) Substance Use Disorders
Interventions
Psychotherapy (Anxiety Sensitivity Intervention)
Behavioral
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 27, 2016 · Synced Sep 5, 2026, 2:08 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Testing the Use of Interoceptive Exposure to Reduce Barriers to Psychotherapy

NCT00795379
View directory record Official record
Conditions
Anxiety
Interventions
Interoceptive Exposure
Behavioral
Lead sponsor
G.V. (Sonny) Montgomery VA Medical Center
Federal
Eligibility
18 Years to 65 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2008
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Nov 20, 2008 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional Results available

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study

NCT04043728
View directory record Official record
Conditions
Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Unified Protocol adapted for smoking cessation
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Building Undergraduate Coping & Knowledge for Stress-Resilience

NCT06885320
View directory record Official record
Conditions
Alcohol Use, College Drinking, Anxiety
Interventions
IMPROVE, HET
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intervention for Managing Physical Reactions to Overwhelming Emotions

NCT06299657
View directory record Official record
Conditions
Anxiety, Substance Use Disorders
Interventions
IMPROVE, PHET
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional Results available

BEAST: A Pilot Trial

NCT05416203
View directory record Official record
Conditions
Anxiety Sensitivity, Functional Impairment
Interventions
Brief Enhanced Anxiety Sensitivity Treatment
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Evaluation of a Brief, Online Intervention for Military Personnel

NCT03579706
View directory record Official record
Conditions
Experimental, Placebo Contol
Interventions
Cognitive Anxiety Sensitivity Treatment, Physical Health Education Training
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 16, 2020 · Synced Sep 5, 2026, 2:08 AM EDT
Not listed Phase 2 Interventional

Comparison of Methods for the Delivery of Interoceptive Exposure

NCT01201304
View directory record Official record
Conditions
Anxiety Sensitivity
Interventions
Standard exposure, Enhanced exposure, Intensive exposure, Expressive writing
Behavioral
Lead sponsor
University of Wyoming
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Laramie, Wyoming
Source: ClinicalTrials.gov public record
Updated Jan 30, 2012 · Synced Sep 5, 2026, 2:08 AM EDT
Terminated Not applicable Interventional Results available

Engaging Working Memory and Distress Tolerance to Aid Smoking Cessation

NCT03565497
View directory record Official record
Conditions
Smoking Cessation
Interventions
Wellness Education Control Condition, Mindfulness Training, Mindfulness Training Plus IE
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 16, 2023 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Early Phase 1 Interventional

Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpartum People

NCT06496230
View directory record Official record
Conditions
Opioid Use Disorder, Pregnancy Related
Interventions
Empowering Pregnant Women and People Receiving Medications for Opioid Use Disorder
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Atrial Fibrillation, Cardiac Symptoms, and Anxiety

NCT02133365
View directory record Official record
Conditions
Atrial Fibrillation, Anxiety
Interventions
Mindfulness and Interoceptive Exposure
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Sep 5, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Interoceptive Exposure for Adolescents With Low Weight Eating Disorders

NCT05763849
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Interoceptive Exposure Treatment (IE), Family-Based Treatment (FBT)
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
12 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional Results available

Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder

NCT04293341
View directory record Official record
Conditions
Major Depressive Disorder, Posttraumatic Stress Disorder, Panic Disorder and Agoraphobia
Interventions
Transdiagnostic Behavior Therapy, Cognitive Processing Therapy for PTSD, Cognitive Behavioral Therapy for MDD, Cognitive Behavioral Therapy for Panic Disorder
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Sep 5, 2026, 2:08 AM EDT
Terminated Not applicable Interventional

Distress Tolerance for Benzodiazepine Discontinuation

NCT05250570
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Distress Tolerance - Benzodiazepine Discontinuation (DT-BD), Relaxation Therapy
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania • Wilkinsburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 29, 2023 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Anxiety Sensitivity Treatment for Suicide

NCT01947179
View directory record Official record
Conditions
Anxiety
Interventions
Anxiety Risk Reduction
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 65 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Sep 25, 2013 · Synced Sep 5, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Targeting Transdiagnostic Self-regulatory Factors and Eating Disorder Pathology Among Adults With BInge-spectrum Eating disOrders: A mHEALTH Interoceptive Exposure Intervention (the Bio-HEALTH Study)

NCT06631729
View directory record Official record
Conditions
Eating Disorders
Interventions
HRV-bio, ED-JITAI
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Smoking Treatment and Anxiety Management Program

NCT01753141
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Cognitive Behavioral Therapy for smoking cessation, Cognitive Behavioral Therapy for smoking cessation and anxiety sensitivity reduction.
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 45 Years
Enrollment
378 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Sep 25, 2013 · Synced Sep 5, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reward Systems and Food Avoidance in Eating Disorders

NCT02795455
View directory record Official record
Conditions
Low Weight Eating Disorders, Anorexia Nervosa
Interventions
Interoceptive Exposure (IE), Family Based Therapy-Weight Gain Control (FBT-WG), meal replacement shake
Behavioral · Dietary Supplement
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
12 Years to 18 Years · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Sep 5, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions

NCT05567640
View directory record Official record
Conditions
Anxiety Disorders and Symptoms, Depressive Symptoms
Interventions
The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), Space for depression, Space for resilience
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
1,800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 5, 2026, 2:08 AM EDT
Terminated Not applicable Interventional Results available

Family-Based Interoceptive Exposure for Avoidant Restrictive Food Intake Disorder

NCT06110806
View directory record Official record
Conditions
Avoidant Restrictive Food Intake Disorder
Interventions
MBIE
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
12 Years to 18 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 5, 2026, 2:08 AM EDT