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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: intranasal ketorolac Clear all
Completed Not applicable Interventional Results available

An Efficacy and Safety Trial of Intranasal Ketorolac in Emergency Department Patients for the Treatment of Acute Pain

NCT01471639
View directory record Official record
Conditions
Other Acute Pain
Interventions
intranasal ketorolac
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Sep 26, 2026, 1:22 AM EDT
Recruiting Phase 1Phase 2 Interventional

Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease

NCT06158620
View directory record Official record
Conditions
Post Operative Pain, Urolithiasis, Ureter Calculi, Stent Complication
Interventions
intra-nasal ketorolac, oral diclofenac
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Sep 26, 2026, 1:22 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

Intranasal Ketorolac Trial

NCT06083571
View directory record Official record
Conditions
Headache, Migraine
Interventions
Ketorolac, Prochlorperazine, Diphenhydramine
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
6 Years to 17 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 26, 2026, 1:22 AM EDT
Terminated Phase 4 Interventional Results available

The Use of Intranasal Ketoralac for Pain Management (Sprix)

NCT01736358
View directory record Official record
Conditions
Postoperative Pain Management, Urolithiasis
Interventions
Intranasal Ketoralac, Placebo
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Sep 26, 2026, 1:22 AM EDT
Completed Phase 2 Interventional

A Single-dose Study of Intranasal Ketorolac in the Treatment of Pain Secondary to Dental Impaction Surgery

NCT01356225
View directory record Official record
Conditions
Pain, Dental Impaction
Interventions
Ketorolac tromethamine, Placebo
Drug
Lead sponsor
Egalet Ltd
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2017 · Synced Sep 26, 2026, 1:22 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Sprix for Postoperative Pain Control Following Gynecologic Surgery

NCT04444830
View directory record Official record
Conditions
Post Operative Pain Control, Narcotic Use, Pelvic Organ Prolapse, Urinary Incontinence , Stress, Surgery
Interventions
Sprix
Drug
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Sep 26, 2026, 1:22 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Safety and Pharmacokinetics Study of Intranasal Ketorolac in Elderly and Nonelderly Adult Healthy Subjects

NCT01365624
View directory record Official record
Conditions
Healthy Subjects
Interventions
Ketorolac tromethamine
Drug
Lead sponsor
American Regent, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 5, 2013 · Synced Sep 26, 2026, 1:22 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Pharmacokinetics of Intranasal Ketorolac in Children

NCT02297906
View directory record Official record
Conditions
Evaluating Pharmacokinetics of Intranasal Ketorolac, Pain
Interventions
Ketorolac
Drug
Lead sponsor
Columbia University
Other
Eligibility
8 Years to 17 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Sep 26, 2026, 1:22 AM EDT
Not listed Phase 4 Interventional

Ketamine v. Ketorolac for Management of Generalized Tension Type Headache

NCT03221569
View directory record Official record
Conditions
Migraine
Interventions
Intravenous ketamine, Ketorolac, Normal saline
Drug
Lead sponsor
The Brooklyn Hospital Center
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Sep 26, 2026, 1:22 AM EDT
Completed Phase 4 Interventional

Intranasal Ketorolac Tromethamine (Sprix) for Acute Pain of Interstitial Cystitis Flare of Pain

NCT02000401
View directory record Official record
Conditions
Interstitial Cystitis
Interventions
Ketorolac Tromethamine
Drug
Lead sponsor
Citrus Valley Medical Research, Inc.
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Glendora, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2013 · Synced Sep 26, 2026, 1:22 AM EDT
Completed Phase 4 Interventional Results available

Intranasal Ketorolac for Postsurgical Pain in Dental Implant Patients

NCT01490931
View directory record Official record
Conditions
Acute Pain
Interventions
Ketorolac Nasal Spray
Drug
Lead sponsor
Hersh, Elliot V., DMD, MS, PhD
Individual
Eligibility
18 Years to 64 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2014 · Synced Sep 26, 2026, 1:22 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"

NCT03081416
View directory record Official record
Conditions
Headache, Intranasal Ketamine
Interventions
Ketamine, Normal saline, Metoclopramide, Ketorolac, Dexamethasone, Benadryl
Drug
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Sep 26, 2026, 1:22 AM EDT
Completed Phase 3 Interventional

Pharmacokinetics, Safety, and Efficacy of SPRIX in 12 to 17 Year Old Patients vs. Adult Patients Undergoing Open Surgical Procedures

NCT01819610
View directory record Official record
Conditions
Pain
Interventions
SPRIX
Drug
Lead sponsor
American Regent, Inc.
Industry
Eligibility
12 Years to 64 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Norristown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2015 · Synced Sep 26, 2026, 1:22 AM EDT
Not listed Phase 4 Interventional

Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children

NCT02653742
View directory record Official record
Conditions
Pain, Postoperative, Otitis Media
Interventions
Ketorolac, Fentanyl
Drug
Lead sponsor
Anica Crnkovic
Other
Eligibility
8 Months to 7 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Sep 12, 2021 · Synced Sep 26, 2026, 1:22 AM EDT
Completed Phase 3 Interventional

Safety and Efficacy of Multiple Doses of Intranasal Ketorolac in Postoperative Pain Following Major Abdominal Surgery

NCT00266786
View directory record Official record
Conditions
Postoperative Pain
Interventions
Intranasal Ketorolac Tromethamine, Intranasal Placebo
Drug
Lead sponsor
Egalet Ltd
Industry
Eligibility
18 Years to 64 Years
Enrollment
321 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
5
States / cities
Arcadia, California • Glendale, California • Pasadena, California + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2017 · Synced Sep 26, 2026, 1:22 AM EDT
Completed Phase 3 Interventional Results available

Intranasal Ketorolac Versus Intravenous Ketorolac for Treatment of Migraine Headaches in Children

NCT02358681
View directory record Official record
Conditions
Migraine
Interventions
Ketorolac, intranasal, Ketorolac, intravenous, Placebo, intravenous, Placebo, intranasal
Drug
Lead sponsor
Columbia University
Other
Eligibility
8 Years to 17 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Sep 26, 2026, 1:22 AM EDT