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ClinicalTrials.gov public records Last synced Oct 17, 2026, 6:01 PM EDT

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Showing 1–24 of 104 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: isometric exercise Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Acute Effects of an Isometric Loading Intervention on Lower Extremity Landing Biomechanics in Individuals With Patellar Tendinopathy

NCT03262181
View directory record Official record
Conditions
Tendinopathy
Interventions
Isometric Exercise, Sham Transcutaneous Electrical Nerve Stimulation
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
15 Years to 28 Years · Male only
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2019 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Aging and the Mitochondrial Response to Exercise Training, Measured by Noninvasive 31P Magnetic Resonance Spectroscopy

NCT04799171
View directory record Official record
Conditions
Physical Activity
Interventions
Isometric Contraction Exercise - Young Adults (Age group 18-39), Isometric Contraction Exercise - Middle Age Adults (Age group 40-59), Isometric Contraction Exercise - Old Adults (Age group >60)
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years and older
Enrollment
352 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 17, 2026, 6:01 PM EDT
Terminated Not applicable Interventional

Influence of Opioid Use on the Effects of Spinal Manipulative Therapy for Low Back Pain

NCT03749564
View directory record Official record
Conditions
Low Back Pain, Opioid Use
Interventions
SMT, Activation Exercises, Mobilizing Exercises, Extended SMT
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Optimizing Impact of Manual Therapy on Lumbar Spinal Stenosis

NCT06023498
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Manual Therapy and Exercise, Intramuscular Electroacupuncture
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Orlando, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

NCT05945771
View directory record Official record
Conditions
Dietary Supplementation
Interventions
Grape seed extract
Dietary Supplement
Lead sponsor
California Baptist University
Other
Eligibility
18 Years to 30 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2023 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Physical Therapy for Anal Incontinence

NCT03252951
View directory record Official record
Conditions
Anal Incontinence, Fecal Incontinence
Interventions
Eccentric Training, Concentric Training, Isometric Training, Biofeedback
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
22 Years and older · Female only
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2022 · Synced Oct 17, 2026, 6:01 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Increasing the Repertoire of Intermuscular Co-ordination Post Stroke Through EMG-Guided Human-Machine Interaction

NCT06523335
View directory record Official record
Conditions
Stroke
Interventions
Neuromuscular coordination-guided rehabilitative training, Force strengthening-guided rehabilitative training
Other
Lead sponsor
University of Houston
Other
Eligibility
40 Years to 75 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 17, 2026, 6:01 PM EDT
Terminated Not applicable Interventional

Knee Isometric Program (KIP) Home Exercise Programs (HEP) Physical Therapy (PT) Study

NCT06536426
View directory record Official record
Conditions
Anterior Knee Pain Syndrome
Interventions
Knee Isometric Program (KIP)
Behavioral
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Phase 4 Interventional Results available

Maintain Respiratory Muscle Function and Reduce Pneumonia Risk in Cancer Patients

NCT03469271
View directory record Official record
Conditions
Cancer
Interventions
1,25 (OH)2 D3, Inspiratory isometric resistance training, Oral Placebo, Sham Inspiratory Isometric Resistance Training, Threshold Inspiratory Muscle Trainer (IMT)
Drug · Other · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 26, 2023 · Synced Oct 17, 2026, 6:01 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effects of Isometric Exercises on Balance, Heart Rate, Pulse Ox and Blood Pressure

NCT02599727
View directory record Official record
Conditions
Exercise, Isometric
Interventions
Isometric exercises, No exercise
Other
Lead sponsor
Carrick Institute for Graduate Studies
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Cape Canaveral, Florida
Source: ClinicalTrials.gov public record
Updated Feb 20, 2017 · Synced Oct 17, 2026, 6:01 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pain in Aging Former Athletes, Master's Athletes, and Nonathletes

NCT07502742
View directory record Official record
Conditions
Pain, Pain Management, Athlete, Exercise Training, Sports Medicine, Strength Training Effects, Aerobic Exercise, Strength Training, Aging, Quality of Life, Sports
Interventions
Moderate-Intensity Strength Exercise Intervention, Moderate-Intensity Aerobic Exercise Intervention
Other
Lead sponsor
Marquette University
Other
Eligibility
35 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Phase 1Phase 2 Interventional

Treating Chronic Cervicogenic Head and Neck Pain

NCT05617365
View directory record Official record
Conditions
Cervicogenic Headache, Neck Pain, Posterior
Interventions
Osteopathic Manipulative Therapy and Exercise Therapy
Combination Product
Lead sponsor
Michigan State University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 17, 2026, 6:01 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Acute Cryotherapy on Musculoskeletal Function and Biomarkers

NCT07211412
View directory record Official record
Conditions
Exercise Induced Muscle Damage, Cryotherapy
Interventions
Cryotherapy, Eccentric exercise-induced muscle damage
Other
Lead sponsor
University of Texas, El Paso
Other
Eligibility
18 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional

The BEE-Power Study (Boosting Exercise for Excellent Pediatric Blood Pressure)

NCT06444464
View directory record Official record
Conditions
Overweight and Obesity, Adolescent Obesity, Exercise
Interventions
Aerobic exercise, Isometric exercise
Other
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
13 Years to 17 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Nutritional Supplement, Eccentric Exercise and Recovery

NCT01444170
View directory record Official record
Conditions
Injury, Inflammation
Interventions
dicreatinol sulfate, placebo sugar pill
Dietary Supplement · Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 25 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 15, 2019 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Hip Activation Compared to Hip Plus Balance Training on the Forward-Step-Down Test

NCT06298903
View directory record Official record
Conditions
Control of Frontal Plane Biomechanics, Patellofemoral Pain Syndrome
Interventions
Hip Activation, Hip activation + Single leg balance
Other
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 13, 2024 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Phase 2 Interventional

Study of the Effects Strengthening Exercises in Individuals With ALS

NCT00204464
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis
Interventions
Exercise
Procedure
Lead sponsor
University of Saskatchewan
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2004
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 4, 2005 · Synced Oct 17, 2026, 6:01 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Recurrent Low Back Pain:Linking Mechanisms to Outcomes

NCT01085604
View directory record Official record
Conditions
Low Back Pain
Interventions
Core Stabilization
Other
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 65 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • West Chester, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 2, 2018 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional Results available

Immediate Effects of rTMS on Excitability of the Quadriceps With Knee Osteoarthritis

NCT02881775
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
rTMS and exercise, Sham rTMS and exercise
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
40 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2019 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Use of Blood Flow Restriction (BFR) Therapy in Post-operative Rehabilitation Following Distal Biceps Tendon Repair

NCT04503421
View directory record Official record
Conditions
Bicep Tendon Rupture
Interventions
Blood Flow Restriction Therapy
Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 8, 2023 · Synced Oct 17, 2026, 6:01 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effects of Brief Periods of Exercise on Blood Pressure

NCT07453550
View directory record Official record
Conditions
Hypertension (HTN), Pre Hypertension
Interventions
wall-squat, wall-squat-tradition
Behavioral
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Isometric Exercise and Endogenous Pain Inhibition

NCT03778476
View directory record Official record
Conditions
Fibromyalgia
Interventions
Isometric Exercise
Other
Lead sponsor
Marquette University
Other
Eligibility
18 Years to 75 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Identify Patients With Neck Pain Likely to Benefit From Education and Exercise

NCT01144884
View directory record Official record
Conditions
Neck Pain
Interventions
Procedure (education and exercise)
Other
Lead sponsor
William J. Hanney
Other
Eligibility
18 Years and older
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
9
States / cities
Altamonte Springs, Florida • Jacksonville, Florida • Kissimmee, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated May 20, 2014 · Synced Oct 17, 2026, 6:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lower Extremity BFR-randomized Controlled Trial Healthy Volunteers

NCT05868304
View directory record Official record
Conditions
Healthy
Interventions
BFR, Stanard strengthening program.
Device · Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Oct 17, 2026, 6:01 PM EDT