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ClinicalTrials.gov public records Last synced Oct 19, 2026, 7:48 PM EDT

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Showing 1–24 of 40 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: ketone ester Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Pharmacokinetics of C6 Ketone Di-ester

NCT05310058
View directory record Official record
Conditions
Pharmacokinetics
Interventions
C6 ketone di-ester
Dietary Supplement
Lead sponsor
BHB Therapeutics, Ireland LTD
Industry
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Oct 19, 2026, 7:48 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction

NCT05519644
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Sleep Deprivation, Heart Rate, Sleep Monitoring, Diet, Exercise Performance, Surveys, McGill Pain Questionnaire, Shortened Profile of Mood States, Pittsburg Sleep Index, Cognitive performance, Marksmanship Performance, Quick Board, Advanced Medical Technologies Inc, Jump Test, CGM/CKM, Blood Draw, Ketone Supplement
Other · Behavioral · Biological + 1 more
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Ketogenic Diet on Glucose Metabolism and Energy Expenditure in Type 2 Diabetes

NCT04791787
View directory record Official record
Conditions
Glucose Metabolism Disorders (Including Diabetes Mellitus), Energy Supply; Deficiency, Type 2 Diabetes
Interventions
Standard weight maintaining diet, Weight maintaining isocaloric ketogenic diet, Beta-hydroxy butyrate
Other · Dietary Supplement
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Oct 19, 2026, 7:48 PM EDT
Recruiting Not applicable Interventional

Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot

NCT07227363
View directory record Official record
Conditions
PCOS (Polycystic Ovary Syndrome)
Interventions
Ketogenic diet, Exogenous Ketone Supplement
Other · Dietary Supplement
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Recruiting Not applicable Interventional

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

NCT06078683
View directory record Official record
Conditions
Type 2 Diabetes, Ketone Body Metabolism, Ketones, Metabolism
Interventions
Ketone Ester Acute, Placebo Acute
Dietary Supplement
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Comparison of Pharmacokinetic Responses to Three Ketone Esters

NCT07289165
View directory record Official record
Conditions
Healthy Volunteer
Interventions
Dietary Supplement containing Tri-betahydroxybutyrin, Dietary Supplement containing a ketone mono Ester, Dietary supplement containing a ketone salt
Dietary Supplement
Lead sponsor
NeuroEnergy Ventures, Inc.
Industry
Eligibility
30 Years to 70 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Canfield, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 19, 2026, 7:48 PM EDT
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging

NCT04275453
View directory record Official record
Conditions
Healthy
Interventions
FDG, Ketone Drink, Ketogenetic Diet
Drug · Dietary Supplement · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 16, 2020 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ketone Esters for Optimization of Operator Performance in Hypoxia

NCT07065864
View directory record Official record
Conditions
Hypoxia
Interventions
Ketone ester, Placebo
Dietary Supplement · Other
Lead sponsor
Florida Institute for Human and Machine Cognition
Other
Eligibility
18 Years and older · Male only
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Pensacola, Florida
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ketone Supplementation in Adolescents Post-Concussion

NCT04079907
View directory record Official record
Conditions
Concussion, Mild, Concussion, Severe, Concussion, Brain, Concussive Injury, Sport Injury, Sports Injuries in Children
Interventions
Ketone, Placebo
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
13 Years to 19 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 19, 2026, 7:48 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.

NCT06075914
View directory record Official record
Conditions
Sleep Deprivation, Nutritional Intervention
Interventions
Ketogenic Intervention, Mediterranean Intervention, Placebo, Ketone Ester
Other · Dietary Supplement
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Withdrawn Not applicable Interventional

The Brain Ketone Body Challenge Imaging Study

NCT03204604
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Challenge A - low calorie Ensure®, Challenge B - Ensure® plus ketone esters (KE), PET Scan, Cognitive Testing - FCSRT, Story Recall, BVRT, CogState One Card Learning
Dietary Supplement · Procedure · Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
50 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2019 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sensory Analysis and Taste Modulation of Ketone Esters

NCT04289454
View directory record Official record
Conditions
Flavor Perception in Normal, Healthy Adults
Interventions
Flavor additive
Other
Lead sponsor
Monell Chemical Senses Center
Other
Eligibility
21 Years to 45 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Oct 19, 2026, 7:48 PM EDT
Enrolling by invitation Phase 2Phase 3 Interventional Accepts healthy volunteers

Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder

NCT05015881
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Alcohol Drinking
Interventions
Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", FDG
Dietary Supplement · Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Phase 2 Interventional Results available

Acute Effects of Exogenous Ketone Ester Administration in Heart Failure

NCT04633460
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction
Interventions
Ketone ester, placebo drink
Dietary Supplement
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 85 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 27, 2024 · Synced Oct 19, 2026, 7:48 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Targeting Aging With a Ketone Ester for Function in Frailty

NCT06645847
View directory record Official record
Conditions
Frail Elderly, Aging, Immune Function, Muscle Function
Interventions
Ketone ester, Placebo Comparator: Non-ketone placebo
Other
Lead sponsor
Buck Institute for Research on Aging
Other
Eligibility
65 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
3
States / cities
Novato, California • Farmington, Connecticut • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Ketone Ester Intervention in Alcohol Use Disorder

NCT04616781
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder
Interventions
Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", Isocaloric dextrose placebo, Alcohol drinks
Dietary Supplement · Drug · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ketone Ester and Salt (KEAS) in Young Adults

NCT05545501
View directory record Official record
Conditions
Salt; Excess, Hypertension
Interventions
No Salt, No β-OHB, High Salt, No β-OHB, High Salt, High β-OHB
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
19 Years to 39 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ketone Ester Supplementation and Nocturnal Blood Pressure

NCT05888506
View directory record Official record
Conditions
Cardiovascular Diseases in Old Age, Aging, Cardiovascular Diseases, Sleep
Interventions
Ketone Ester, Placebo
Dietary Supplement
Lead sponsor
Georgia Southern University
Other
Eligibility
50 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Savannah, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 6, 2023 · Synced Oct 19, 2026, 7:48 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Acute Ketone Supplementation on the Brain

NCT07711990
View directory record Official record
Conditions
Brain Health
Interventions
Ketone Ester Drink, Placebo
Dietary Supplement
Lead sponsor
Christopher Crabtree
Other
Eligibility
45 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Ketones

NCT05778695
View directory record Official record
Conditions
Parkinson Disease, Lewy Body Dementia, Parkinson Disease Dementia
Interventions
Ketone Ester (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate
Dietary Supplement
Lead sponsor
University of Michigan
Other
Eligibility
45 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional Results available

Effects of Exercise Training and Ketone Ester on Muscle Strength and Cardiovascular Response in Parkinson's Disease

NCT05948956
View directory record Official record
Conditions
Parkinson Disease
Interventions
Ketone Ester Beverage, Electrolyte Beverage, Cycling Intervention
Dietary Supplement · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
45 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Ketone Supplements and Substrate Oxidation and Physical Performance

NCT04737694
View directory record Official record
Conditions
Ketosis, Glucose Metabolism
Interventions
Ketone ester, Glucose
Dietary Supplement
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 39 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 14, 2021 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

BHB and Cognition During Exercise-Heat Stress

NCT07010666
View directory record Official record
Conditions
Healthy
Interventions
Beta-Hydroxybutyrate, Carbohydrate, Caffeine
Dietary Supplement
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 35 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 8, 2025 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Effect of Ketone Esters in Parkinson's Disease

NCT04477161
View directory record Official record
Conditions
Parkinson Disease, Ketosis
Interventions
Ketone Ester Elite endurance Nutrition Drink, Stool Sample
Dietary Supplement · Other
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 4, 2022 · Synced Oct 19, 2026, 7:48 PM EDT