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ClinicalTrials.gov public records Last synced Oct 5, 2026, 10:34 PM EDT

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Showing 25–48 of 114 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: lidocaine/bupivacaine Clear all
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

NCT04814433
View directory record Official record
Conditions
Opioid Pain Medication
Interventions
Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin, Lidocaine Hydrochloride with Epinephrine, Bupivacaine Hydrochloride with Epinephrine
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 99 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 5, 2026, 10:34 PM EDT
Recruiting Phase 4 Interventional

Pectoral Block in Breast Reduction for Pain Control

NCT07527039
View directory record Official record
Conditions
Macromastia (Symptomatic)
Interventions
Pectoral II Nerve Block, Post Operative Pain Relievers
Procedure · Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 5, 2026, 10:34 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Depodur vs Fentanyl Infusion for Post-C/S Analgesia

NCT00762554
View directory record Official record
Conditions
Analgesia
Interventions
Depodur, Fentanyl
Drug
Lead sponsor
Goodman, Evan, M.D.
Individual
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 29, 2022 · Synced Oct 5, 2026, 10:34 PM EDT
Not listed Phase 4 Interventional

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

NCT02958566
View directory record Official record
Conditions
Colon Cancer, Colon Diverticulosis, Colonic Neoplasms, Colonic Diverticulitis, Pain, Postoperative, Ileus, Ileus Paralytic, Ileus; Mechanical, Constipation Drug Induced, Constipation, Rectum Cancer, Rectum Neoplasm
Interventions
Acetaminophen, Gabapentin, Orphenadrine, Lidocaine, Marcaine, Ketamine, Methadone, Tramadol, Ketorolac, Morphine Sulfate, Fentanyl, Dilaudid, Hydrocodone-Acetaminophen Tab 5-325 MG, HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
Drug
Lead sponsor
University of Illinois College of Medicine at Peoria
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Oct 5, 2026, 10:34 PM EDT
Recruiting Phase 4 Interventional

Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy

NCT06189781
View directory record Official record
Conditions
Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
Interventions
Ropivacaine injection, Bupivacaine, lidocaine, ropivacaine
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Up to 18 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
4
States / cities
Los Angeles, California • Santa Monica, California • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Phase 4 Interventional

Liposomal Bupivacaine Versus Bupivacaine for for Postoperative Pain Control in Shoulder Surgery

NCT04180943
View directory record Official record
Conditions
Anesthesia, Local
Interventions
interscalene nerve block
Drug
Lead sponsor
Bassett Healthcare
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cooperstown, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Phase 4 Interventional

Bupivacaine Versus Lidocaine on Inflammatory Regulation

NCT01060774
View directory record Official record
Conditions
Pain
Interventions
Lidocaine, Bupivacaine
Drug
Lead sponsor
University of Maryland
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Phase 4 Interventional Results available

Greater Occipital Nerve Block for Migraine Prophylaxis

NCT00915473
View directory record Official record
Conditions
Migraine Headache
Interventions
bupivicaine, normal saline, methylprednisolone, lidocaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 20, 2014 · Synced Oct 5, 2026, 10:34 PM EDT
Terminated Phase 3 Interventional Results available

A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain

NCT05658874
View directory record Official record
Conditions
Interstitial Cystitis, Levator Spasm, Bladder Pain Syndrome
Interventions
Multimodal Bundle Drugs, Operative Cystoscopy, Behavioral health consultation/therapy, Pelvic floor physical therapy, Usual Urogynecologic care, Bladder Instillation, Vaginal estrogen, Methenamine, Amitriptyline/Gabapentin
Drug · Procedure · Behavioral + 1 more
Lead sponsor
Jocelyn Fitzgerald
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Phase 4 Interventional Results available

Steroids in Occipital Nerve Block for Treatment of Headache

NCT05732532
View directory record Official record
Conditions
Headache, Occipital Nerve Block
Interventions
Bupivacaine, Lidocaine, Dexamethasone, Normal saline, Greater/lesser occipital nerve blocks
Drug · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Phase 4 Interventional Results available

Trial Liposomal Bupivacaine Following Retropubic Suburethral Sling for Stress Urinary Incontinence

NCT02296099
View directory record Official record
Conditions
Urinary Incontinence, Stress
Interventions
liposomal bupivacaine, Placebo
Drug
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 16, 2018 · Synced Oct 5, 2026, 10:34 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Ice as an Adjunct for Local Anesthesia During Anorectal Surgeries

NCT04000191
View directory record Official record
Conditions
Anesthesia, Local
Interventions
MAC, Perianal ice application
Procedure · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Not applicable Interventional

Synovial Fluid Analysis of Intraarticular Elbow Fracture

NCT02878941
View directory record Official record
Conditions
Elbow Fracture, Joint Contracture
Interventions
Synovial Fluid Analysis
Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Phase 4 Interventional Results available

Trigger Point Injections in Anterior Cervical Surgery

NCT04640896
View directory record Official record
Conditions
Myofacial Pain, Pain, Neck, Pain, Back, Cervical Fusion
Interventions
Trigger point injection with bupivacaine, Trigger point injection with normal saline, Lidocaine skin wheal
Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Phase 3 Interventional Results available

Clinical Trial Comparing Two Bladder Instillations for IC/BPS

NCT03463915
View directory record Official record
Conditions
Interstitial Cystitis, Bladder Pain Syndrome
Interventions
Bladder instillation WITH triamcinolone acetonide, Bladder instillation WITHOUT triamcinolone acetonide
Drug
Lead sponsor
Olivia Cardenas-Trowers, M.D.
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 1, 2021 · Synced Oct 5, 2026, 10:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pain Perception After Tubal Ligation

NCT01062087
View directory record Official record
Conditions
Pain
Interventions
Bupivacaine, Lidocaine
Drug
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
21 Years to 52 Years · Female only
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 3, 2012 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Liposomal Bupivacaine vs. Bupivacaine Hydrochloride and Lidocaine During Suburethral Sling Placement

NCT02875015
View directory record Official record
Conditions
Postoperative Pain
Interventions
Liposomal Bupivacaine, Bupivacaine Hydrochloride and Lidocaine, Suburethral Sling
Drug · Procedure
Lead sponsor
Atlantic Health System
Other
Eligibility
19 Years and older · Female only
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Morristown, New Jersey • Summit, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Not applicable Interventional

Comparative Sedation Study of the MyoSure Hysteroscopic Tissue Removal System

NCT00979342
View directory record Official record
Conditions
Uterine Fibroids, Polyps
Interventions
Hysteroscopic Morcellator
Device
Lead sponsor
Hologic, Inc.
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
5
States / cities
Phoenix, Arizona • Boca Raton, Florida • Detroit, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2010 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Early Phase 1 Interventional

Erector Spinae Regional Anesthesia for Pain Control

NCT05794828
View directory record Official record
Conditions
Pain Management
Interventions
Bupivacaine Injection
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
4
States / cities
Ridley Park, Pennsylvania • Upland, Pennsylvania • San Antonio, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Not applicable Interventional Results available

Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation

NCT00484159
View directory record Official record
Conditions
Low Back Pain
Interventions
Radiofrequency denervation of medial branches, 0.5% bupivacaine, 2% lidocaine, Radiofrequency denervation
Procedure · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 26, 2011 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Phase 3 Interventional Results available

Vertebroplasty for the Treatment of Fractures Due to Osteoporosis

NCT00068822
View directory record Official record
Conditions
Spinal Fractures, Osteoporosis
Interventions
Percutaneous vertebroplasty, Sham vertebroplasty
Device · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 27, 2012 · Synced Oct 5, 2026, 10:34 PM EDT
Not listed Phase 3 Interventional

Intra-articular Analgesia Versus Adductor Canal Block for Arthroscopic Knee Surgery

NCT05004506
View directory record Official record
Conditions
Post-Operative Pain, Chronic
Interventions
Adductor Canal Block, Intra-articular Injection
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Oct 5, 2026, 10:34 PM EDT
Completed Not applicable Interventional

Use of Platelet Rich Plasma Therapy for Acute Ankle Sprains in the Emergency Department

NCT01518335
View directory record Official record
Conditions
Sprain of Ankle
Interventions
Platelet rich plasma injection, Placebo Comparator: Placebo/Standard of Care
Procedure
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Oct 5, 2026, 10:34 PM EDT
Withdrawn Not applicable Interventional

Use of Recombinant Hyaluronidase Human is Effective for the Use of Local Blocks for Eyelid's Surgery

NCT02059694
View directory record Official record
Conditions
Upper Eyelid Surgery
Interventions
Hyaluronidase, 2 mL of lidocaine 2% with epinephrine 1:100,000 without rHuPH20
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 19, 2014 · Synced Oct 5, 2026, 10:34 PM EDT