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ClinicalTrials.gov public records Last synced Oct 14, 2026, 4:58 PM EDT

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Showing 601–624 of 964 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: lidocaine hydrochloride Clear all
Completed No phase listed Observational

Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth

NCT00001952
View directory record Official record
Conditions
Healthy, Inflammation, Mouth Disease, Pain
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Phase 4 Interventional Results available

Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars

NCT01496846
View directory record Official record
Conditions
Irreversible Pulpitis
Interventions
IANB Articaine, SUP Articaine, SUP Lidocaine
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 31, 2017 · Synced Oct 14, 2026, 4:58 PM EDT
Recruiting No phase listed Observational

Measuring Analgesic Interventions

NCT03794362
View directory record Official record
Conditions
Pain
Interventions
Not listed
Lead sponsor
Julia Finkel
Other
Eligibility
7 Years to 21 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 14, 2026, 4:58 PM EDT
Recruiting Phase 4 Interventional

Ketamine as a Supplement to Local Anesthesia for Minor Procedures

NCT06284473
View directory record Official record
Conditions
Pain, Procedural, Minor Laceration, Abscess
Interventions
Ketamine, Saline
Drug · Other
Lead sponsor
Loyola University
Other
Eligibility
7 Years to 70 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 3, 2025 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Phase 2 Interventional Results available

Trigger Point Injection in Reducing Pain Following Total Knee Arthroplasty

NCT06955923
View directory record Official record
Conditions
Trigger Point Pain, Myofascial
Interventions
Trigger point injection (lidocaine), Sham Comparator
Drug · Other
Lead sponsor
David Grant U.S. Air Force Medical Center
Federal
Eligibility
45 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Fairfield, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 14, 2026, 4:58 PM EDT
Not yet recruiting Phase 4 Interventional

Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

NCT07644923
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivacaine, Lidocaine, Thrombin, Tranexamic acid, Aminocaproic acid
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 14, 2026, 4:58 PM EDT
Terminated Phase 4 Interventional

Platelet-rich Plasma, Corticosteroid, or Lidocaine for Acromioclavicular Joint Pain

NCT05161468
View directory record Official record
Conditions
Acromioclavicular Sprain
Interventions
Lidocaine injection, Corticosteroid Injection, Protein Rich Plasma(PRP) Injection
Drug
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Oct 14, 2026, 4:58 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Patient-Applied Pretreatment Analgesia for Intrauterine Device Placement

NCT05890495
View directory record Official record
Conditions
Contraception
Interventions
Lidocaine topical, Tampon
Drug · Device
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 54 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Oct 14, 2026, 4:58 PM EDT
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers

Recalcitrant Pruritus in Cutaneous T-Cell Lymphoma

NCT00863395
View directory record Official record
Conditions
Cutaneous T-Cell Lymphoma
Interventions
skin biopsy
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 31, 2014 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Effect of Paracervical Block Volume on Pain Control for Dilation and Curettage.o

NCT03636451
View directory record Official record
Conditions
Abortion, Spontaneous, Abortion in First Trimester, Pain Uterus, Abortion Early, Abortion, Missed
Interventions
40cc buffered 0.5% lidocaine with 2 units of vasopressin paracervical block, 20cc 1% lidocaine with 2 units of vasopressin paracervical block
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Outcomes of Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine

NCT02708433
View directory record Official record
Conditions
Anesthesia
Interventions
Lidocaine
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 30 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 4, 2018 · Synced Oct 14, 2026, 4:58 PM EDT
Terminated Phase 4 Interventional Results available

Does Low-does Cervical Epidural Lidocaine Cause Transient Weakness?

NCT03382925
View directory record Official record
Conditions
Cervical Radiculopathy
Interventions
cervical interlaminar with lidocaine, cervical interlaminar with normal saline, Lidocaine, Triamcinolone Acetonide, Normal saline
Procedure · Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 25, 2022 · Synced Oct 14, 2026, 4:58 PM EDT
Terminated Phase 3 Interventional Results available

Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders

NCT02266433
View directory record Official record
Conditions
DeQuervains Tenosynovitis, Lateral Epicondylitis, Tennis Elbow, Trigger Finger, Tenosynovitis, Inflammatory Disease
Interventions
Ketorolac, Dexamethasone
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Oct 14, 2026, 4:58 PM EDT
Terminated Not applicable Interventional Results available

Optimal Method for Mydriasis in Cataract Surgery

NCT02909140
View directory record Official record
Conditions
Cataract
Interventions
Topical phenylephrine 2.5%, Topical cyclopentolate 1%, Intracameral Lidocaine 1%, Intracameral 0.2- 0.3ml of epinephrine 1:10,000
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
40 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Oct 14, 2026, 4:58 PM EDT
Withdrawn Phase 4 Interventional

Sphenopalatine Ganglion Block to Prevent Shoulder Pain After Laparoscopic Bariatric Surgery

NCT02809755
View directory record Official record
Conditions
Obesity
Interventions
4% Lidocaine, Saline
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 18, 2019 · Synced Oct 14, 2026, 4:58 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques

NCT00992108
View directory record Official record
Conditions
Face Pain
Interventions
lidocaine, chemodenervation
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 29, 2016 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Not applicable Interventional Results available

Lidocaine and Outpatient Gynecologic Laparoscopy

NCT01250002
View directory record Official record
Conditions
Pain
Interventions
Placebo, Lidocaine
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 26, 2014 · Synced Oct 14, 2026, 4:58 PM EDT
Withdrawn Phase 2 Interventional

Source of Hand Weakness After Stroke

NCT00907829
View directory record Official record
Conditions
Stroke, Cerebrovascular Accident
Interventions
lidocaine, muscle stimulator
Drug · Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
30 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated May 5, 2014 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Phase 2 Interventional Results available

Clostridium Histolyticum Collagenase Injection for Urethral Disease

NCT02948842
View directory record Official record
Conditions
Urethral Stricture
Interventions
Clostridium Histolyticum Collagenase, Saline
Drug · Other
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older · Male only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 3, 2023 · Synced Oct 14, 2026, 4:58 PM EDT
Withdrawn Not applicable Interventional

Use of Recombinant Hyaluronidase Human is Effective for the Use of Local Blocks for Eyelid's Surgery

NCT02059694
View directory record Official record
Conditions
Upper Eyelid Surgery
Interventions
Hyaluronidase, 2 mL of lidocaine 2% with epinephrine 1:100,000 without rHuPH20
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 19, 2014 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Anesthetic Effect Duration Assessment

NCT01545765
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Lidocaine 7% + Tetracaine 7% cream
Drug
Lead sponsor
Galderma R&D
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Rochelle Park, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 2, 2021 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Phase 3 Interventional Results available

Vertebroplasty for the Treatment of Fractures Due to Osteoporosis

NCT00068822
View directory record Official record
Conditions
Spinal Fractures, Osteoporosis
Interventions
Percutaneous vertebroplasty, Sham vertebroplasty
Device · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 27, 2012 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

RHA® Redensity Eye Versus No-treatment for the Infra-Orbital Hollows

NCT04577898
View directory record Official record
Conditions
Infra-orbital Hollows, Tear-trough Deformity, Wrinkle
Interventions
RHA® Redensity Eye
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
248 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
4
States / cities
Encino, California • Santa Monica, California • Coral Gables, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 14, 2026, 4:58 PM EDT
Completed Not applicable Interventional Results available

A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery

NCT02849678
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ropivacaine, Lidocaine
Drug
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years to 80 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 20, 2018 · Synced Oct 14, 2026, 4:58 PM EDT