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Conditions: Medical Oncology, Integrative Oncology, Medical Nutrition Therapy
Interventions: Diet; Other
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 2
States / cities: Buffalo, New York

Conditions: Obesity
Interventions: Low- Carbohydrate -Atkins Diet, Low Calorie Diet; Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2009
U.S. locations: 3
States / cities: Denver, Colorado • St Louis, Missouri • Philadelphia, Pennsylvania

Conditions: Vascular Diseases, Surgery
Interventions: Scandi-Shake; Dietary Supplement
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Nonalcoholic Fatty Liver Disease, Hepatic Steatosis, Steatohepatitis
Interventions: Optifast 800; Dietary Supplement
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 3
States / cities: Worcester, Massachusetts • Lebanon, New Hampshire • Burlington, Vermont

Conditions: Carotid Stenosis, Caloric Restriction
Interventions: ScandiShake; Dietary Supplement
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Diabetes Type II
Interventions: Low Carbohydrate Diet, American Diabetes Association Diet, Mindfulness and Positive Affect Skills; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Alzheimer Disease
Interventions: Lifestyle medicine; Behavioral
Lead sponsor: Preventive Medicine Research Institute; Other
Eligibility: 45 Years to 90 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 4
States / cities: San Diego, California • Sausalito, California • Boston, Massachusetts + 1 more

Conditions: Breast Cancer
Interventions: Nutrition and resistance training exercise intervention; Other
Lead sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute); Other
Eligibility: 20 Years to 89 Years · Female only
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Pre-diabetes
Interventions: Normal Diet, Low carb diet, CGM with no real time feedback, CGM with real time feedback), Education material; Other · Device · Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 21 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Livonia, Michigan

Conditions: Obesity
Interventions: Weight loss; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 25 Years to 60 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes
Interventions: NOURISH Diet, Self-Selected Diet (Control); Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Obesity
Interventions: Advice on diet, physical activity, and behavior change, Instruction in food portion size, Provision of pre-portioned foods, Advice on healthy eating for weight loss; Behavioral · Other
Lead sponsor: Penn State University; Other
Eligibility: 20 Years to 65 Years · Female only
Enrollment: 186 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: University Park, Pennsylvania

Conditions: Obesity
Interventions: Milk Thistle (MT), Lactobacillus Gasseri (LAC), Exercise (EX), Control (CON); Dietary Supplement · Behavioral
Lead sponsor: Kyle Flack; Other
Eligibility: 18 Years to 50 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Obesity, Bariatric Surgery, Morbid Obesity, Diabetes Mellitus Type 2, Diet Therapy
Interventions: Roux-en-Y Gastric Bypass, Caloric Restriction; Other
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2019
U.S. locations: 3
States / cities: Baltimore, Maryland • Bethesda, Maryland • Nashville, Tennessee

Conditions: Morbid Obesity
Interventions: Very low calorie diet; Dietary Supplement
Lead sponsor: Christiana Care Health Services; Other
Eligibility: 18 Years to 65 Years
Enrollment: 58 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Hyperlipidemia
Interventions: MCT oil + Butter in Coffee; Dietary Supplement
Lead sponsor: Walter Reed National Military Medical Center; Federal
Eligibility: 18 Years to 45 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Weight Loss, Vitamin D or Placebo
Interventions: Weight Loss, Vitamin D 2500 IU, Weight Maintenance; Behavioral · Dietary Supplement
Lead sponsor: Rutgers University; Other
Eligibility: 50 Years to 72 Years · Female only
Enrollment: 83 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Obesity, Weight Loss
Interventions: Portion-Controlled Meals, Low-Calorie Diet, Intermittent Very-Low Calorie Diet; Dietary Supplement · Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Aging
Interventions: In-Person Caloric Restriction, Remote Caloric Restriction, Time-restricted; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 60 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage 1 Breast Cancer AJCC v8, Anatomic Stage 2 Breast Cancer AJCC v8, Anatomic Stage 3 Breast Cancer AJCC v8, Breast Ductal Carcinoma in Situ, Invasive Breast Carcinoma, Triple Negative Breast Carcinoma
Interventions: Best Practice, Stereotactic Body Radiation Therapy, Resection, Sentinel Lymph Node Biopsy, Dietary Intervention, Questionnaire Administration, Quality-of-Life Assessment, Mammography, Biospecimen Collection; Other · Radiation · Procedure
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 40 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Obesity; Familial, Pregnancy Related
Interventions: Very-low energy Diet (VLED), Standard of care (SOC); Dietary Supplement · Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 147 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Obesity, Normal Physiology, Healthy Volunteers
Interventions: +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat, +150% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, +200% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein, -25% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, +150% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein; Dietary Supplement
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Genetics, Obesity
Interventions: Diet modification; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 20 Years to 45 Years
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Salt; Excess, Blood Pressure Disorders
Interventions: Allopurinol, Dietary Intervention; Drug · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 22 Years to 33 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

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A Pilot, Feasibility Study of Intermittent Caloric Restriction Plus Plant-based Diet in Cancer Patients Receiving Chemotherapy

The Safety and Efficacy of Low and High Carbohydrate Diets

Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease

A Phase II Study of the Effect of a Low Calorie Diet on Patients Undergoing Liver Resection

Short-Term Endogenous Hydrogen Sulfide Upregulation

A Pilot Study of the Effects of Diet and Behavioral Interventions on Health in Diabetics

Can Lifestyle Changes Reverse Early-Stage Alzheimer's Disease

EXERT-BCN: an Exercise and Nutrition Regimen to Designed to Improve Body Composition After Treatment for Breast Cancer

Continuous Glucose Monitoring (CGM) With a Low Carbohydrate Diet to Reduce Weight in Patients With Pre-Diabetes

Insulin Resistance and Reward Signaling in Obesity

Using Continuous Glucose Monitoring to Quantify the Effects of NOURISH's Culturally Modified Meals on Asian Americans With Type 2 Diabetes

Portion Size Strategies for Management of Body Weight

Exercise, Milk Thistle, and Lactobacillus to Influence Plasma Bilirubin

Effects of Caloric Restriction Alone Versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients With Diabetes Mellitus

Utilization of Very Low Calorie Diet in Obese General Surgery Patients

Effect of Butter & MCT Oil on Lipoproteins - A RCT

The Effect of Vitamin D Supplementation During Caloric Restriction on Intestinal Calcium Absorption

KU Alternate Meal Energy Level Study

Health, Aging and Later-Life Outcomes

Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

Maternal Metabolic and Molecular Changes Induced by Preconception Weight Loss and Their Effects on Birth Outcomes

The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

Inherited and Environmental Risks Acting on Body Weight

Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm