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ClinicalTrials.gov public records Last synced Sep 7, 2026, 7:56 AM EDT

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Showing 1–24 of 156 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: low oxygen therapy Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

NCT05723679
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction, Obesity
Interventions
HeO2 gas mixture, Room air gas mixture
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
55 Years to 90 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 7, 2026, 7:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Human Biological Responses to Low Level Ozone

NCT02857283
View directory record Official record
Conditions
Environmental Exposure, Nasal Inflammation
Interventions
Ozone, Filtered Air, Health and Exposure Tracker (HET)
Other · Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Sep 7, 2026, 7:56 AM EDT
Terminated No phase listed Observational Results available

Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury

NCT02507973
View directory record Official record
Conditions
Injury, Brain, Traumatic, Traumatic Brain Injury
Interventions
Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
14 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Sep 7, 2026, 7:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers

NCT02415270
View directory record Official record
Conditions
Tobacco Smoking Behavior
Interventions
Reduced Nicotine Cigarettes, Reduced ROS/RNS, Control
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2018 · Synced Sep 7, 2026, 7:56 AM EDT
Recruiting Not applicable Interventional

Combination Therapy to Improve SCI Recovery.

NCT05563103
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Daily acute intermittent hypoxia, Room air (SHAM), Walking + tSTIM, Walking + Sham transcutaneous spinal stimulation (tSHAM)
Other
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Sep 7, 2026, 7:56 AM EDT
Terminated Phase 3 Interventional

Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure

NCT00016523
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Respiratory Distress Syndrome (RDS), Sepsis, Pneumonia, Hypertension, Pulmonary
Interventions
Inhaled nitric oxide, Placebo
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 120 Hours
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
17
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Sep 7, 2026, 7:56 AM EDT
Recruiting Not applicable Interventional

Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2)

NCT05967507
View directory record Official record
Conditions
Airway Management
Interventions
Low-flow nasal supplemental oxygen with a conventional nasal cannula during tracheal intubation with the C-MAC video laryngoscope, High-flow nasal supplemental oxygen (Fisher & Paykel, Auckland, New Zealand) during tracheal intubation with the C-MAC video laryngoscope
Device
Lead sponsor
Thomas Riva
Other
Eligibility
Up to 52 Weeks
Enrollment
1,192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 7, 2026, 7:56 AM EDT
Not listed Not applicable Interventional

Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation

NCT02460653
View directory record Official record
Conditions
Respiratory Insufficiency, Hypoxia
Interventions
HFNC Flow Rate
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
4 Weeks to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Sep 7, 2026, 7:56 AM EDT
Terminated Not applicable Interventional

Extubation Readiness Study in Very Low Birthweight Infants

NCT01471431
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
spontaneous breathing trial
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
48 Hours to 14 Weeks
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Phialdelphia, Pennsylvania • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 6, 2016 · Synced Sep 7, 2026, 7:56 AM EDT
Enrolling by invitation Phase 4 Interventional

Nanozymes in Endodontics

NCT07518901
View directory record Official record
Conditions
Apical Periodontitis, Endodontic Disease, Root Canal Infection
Interventions
Nanozyme treatment, Control (Standard treatment)
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 7, 2026, 7:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury

NCT02323945
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
AIH, Walk, Strength
Other
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Sep 7, 2026, 7:56 AM EDT
Completed Phase 3 Interventional

Evaluation of Oral Simethicone With Low Volume Polyethylene Glycol Bowel Preparation During Colonoscopy

NCT03410524
View directory record Official record
Conditions
Colonoscopy
Interventions
Simethicone Solution, Water
Drug
Lead sponsor
University of Nevada, Reno
Other
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
2
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Sep 7, 2026, 7:56 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia

NCT03192488
View directory record Official record
Conditions
Hypoxia, Altitude
Interventions
Cetirizine, Placebo oral capsule, Hypoxia
Drug · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 35 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 15, 2020 · Synced Sep 7, 2026, 7:56 AM EDT
Terminated Not applicable Interventional

Conjugated Hyperbilirubinemia and Pulse Oximetry

NCT00741117
View directory record Official record
Conditions
Liver Disease, Hyperbilirubinemia
Interventions
Arterial Blood Gas, Pulse Oximetry Machine, Direct and Indirect Serum Bilirubin Measurement
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 5, 2013 · Synced Sep 7, 2026, 7:56 AM EDT
Not listed Phase 3 Interventional

Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)

NCT02089594
View directory record Official record
Conditions
Post-Concussion Syndrome, Traumatic Brain Injury
Interventions
Hyperbaric Oxygen, No Hyperbaric Oxygen
Drug
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 7, 2026, 7:56 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Daily Low Oxygen Exposure and Weight Status

NCT04801810
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Normobaric hypoxia, Normobaric normoxia
Other
Lead sponsor
Florida State University
Other
Eligibility
20 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Mar 31, 2022 · Synced Sep 7, 2026, 7:56 AM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Intracervical Balloon Placement With Nitrous Oxide Administration

NCT06498908
View directory record Official record
Conditions
Labor Pain, Induced; Birth
Interventions
Nitrous oxide, Oxygen
Drug
Lead sponsor
Olivia Sher
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Sep 7, 2026, 7:56 AM EDT
Completed Not applicable Interventional

FLO2 for Recovery After SCI

NCT03833674
View directory record Official record
Conditions
Spinal Cord Injury (SCI)
Interventions
Daily AIH Block, Sham dAIH Block, Respiratory Strength Training Block, AIH + Strength Training Block
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Sep 7, 2026, 7:56 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Using Magnetic Resonance (MR) to Understand the Effect of Erythromycin on Bowel Motility

NCT01379183
View directory record Official record
Conditions
Healthy
Interventions
Erythromycin, Placebo, Magnetic Resonance Imaging, Barium Sulfate Solution
Drug · Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 20, 2016 · Synced Sep 7, 2026, 7:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Placenta Imaging Project

NCT02749851
View directory record Official record
Conditions
High Risk Pregnancy
Interventions
MRI, MRI - IUGR
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 52 Years · Female only
Enrollment
379 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
Portland, Oregon • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 4, 2020 · Synced Sep 7, 2026, 7:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

NCT05216042
View directory record Official record
Conditions
Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure, Glucose Metabolism, Exercise, Obesity
Interventions
Study diet, Exercise capacity VO2 max determination, Exercise Challenge, Glucose Challenge
Dietary Supplement · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 7, 2026, 7:56 AM EDT
Recruiting Phase 2 Interventional

Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology

NCT06336642
View directory record Official record
Conditions
Dyspnea
Interventions
SPOT-ON Early Start, SPOT-ON Delayed Start
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2032
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Sep 7, 2026, 7:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults

NCT07144527
View directory record Official record
Conditions
Aging, Frailty, Exercise Tolerance, Healthy Male and Female Subjects
Interventions
NMN, betaine, low-dose hydrogen peroxide (EGA), Nicotinamide Mononucleotide (NMN), Placebo
Dietary Supplement
Lead sponsor
Scott Silveira
Other
Eligibility
60 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Beverly Hills, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 7, 2026, 7:56 AM EDT
Terminated Not applicable Interventional Results available

Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI

NCT04854057
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
AIH - Intermittent Hypoxia - hypoxia air mixture, SHAM - Intermittent Room Air - room air mixture, TESS - Transcutaneous Electrical Spinal Cord Stimulation + Functional Task Practice
Other · Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Sep 7, 2026, 7:56 AM EDT