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Showing 1–24 of 158 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: low sodium diet Clear all
Not yet recruiting Not applicable Interventional

Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).

NCT07832942
View directory record Official record
Conditions
Genetics in Hypertension
Interventions
low sodium diet, high sodium diet, renal plasma flow, SIEA collection
Other · Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preliminary Effect of Food Processing and Sweeteners on Glycemic and Metabolic Measures

NCT05658757
View directory record Official record
Conditions
Blood Sugar; High, Blood Pressure, Dietary Habits
Interventions
Regular sweetened commercial foods, Allulose sweetened commercial foods, Whole and minimally processed and sweetened foods
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
20 Years to 99 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Dietary Salt Intake on Immune Function in Patients With Multiple Sclerosis

NCT02282878
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
High/Low Sodium Diet
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 18, 2021 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Early Phase 1 Interventional

ETCare: Safety and Preliminary Efficacy Trial

NCT01688440
View directory record Official record
Conditions
Respiratory Distress Syndrome, Newborn
Interventions
#1 Respiratory Care Solution
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
Not listed
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
2
States / cities
Ogden, Utah • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 18, 2012 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome

NCT01563107
View directory record Official record
Conditions
Postural Orthostatic Tachycardia Syndrome
Interventions
Plasma Volume, Exercise Capacity Test - Bicycle, Posture Study
Radiation · Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 24, 2022 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional

When the Kidney Reacts to Nutritional Changes

NCT04142138
View directory record Official record
Conditions
Prehypertension
Interventions
DASH
Other
Lead sponsor
Rockefeller University
Other
Eligibility
18 Years to 60 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Racial/Ethnic in Calcium and Sodium Metabolism

NCT05537857
View directory record Official record
Conditions
Healthy
Interventions
High dietary salt
Other
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 50 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Dietary Sodium Restriction of Improving Vascular Endothelial Function in Middle Aged and Older Adults

NCT01566084
View directory record Official record
Conditions
Hypertension
Interventions
Slow sodium tablets, placebo
Drug · Other
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
50 Years to 79 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 6, 2016 · Synced Sep 23, 2026, 10:45 PM EDT
Terminated Not applicable Interventional

Reducing Insulin, Growth Hormones, and Tumors

NCT03785808
View directory record Official record
Conditions
Diet Modification, Lung Cancer
Interventions
Special Diet Therapy (low-carb), Special Diet Therapy (low-fat), Special Diet Therapy (USDA control)
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 11, 2019 · Synced Sep 23, 2026, 10:45 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Salt and TH-17 in Healthy Human Subjects

NCT02261688
View directory record Official record
Conditions
Th17 Helper Immune Cells, Autoimmunity, Salt Intake, Sodium Chloride
Interventions
Low salt diet, Low salt diet + IV normal saline, Liberal salt diet
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 7, 2021 · Synced Sep 23, 2026, 10:45 PM EDT
Active, not recruiting Not applicable Interventional

Dine and DASH Into Wellness Pilot Study

NCT07175896
View directory record Official record
Conditions
Chronic Kidney Disease, Diet Interventions, Disease Prevention
Interventions
Immediate delivery of low-sodium DASH (Dietary Approaches to Stop Hypertension) diet group coaching plus hand-on cooking program, Delayed delivery of low-sodium DASH (Dietary Approaches to Stop Hypertension) diet group coaching plus hand-on cooking program
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study With CIN-107 Following Multiple Oral Ascending Doses in Healthy Subjects

NCT05500820
View directory record Official record
Conditions
Hypertension
Interventions
CIN-107, Matching Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 55 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Studies on Aldosterone and Vascular Function

NCT00700479
View directory record Official record
Conditions
Inflammation
Interventions
aldosterone, low or high sodium diet, placebo
Drug · Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 17, 2008 · Synced Sep 23, 2026, 10:45 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of Dietary Sodium and Potassium Citrate on Renal Mineral Handling

NCT03281928
View directory record Official record
Conditions
Kidney Stone
Interventions
Sodium and Potassium Citrate, Placebo
Dietary Supplement
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 21, 2025 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Sodium Reduction on Blood Pressure and Physical Function in Older Adults

NCT04074941
View directory record Official record
Conditions
Hypertension, Physical Disability, Aging
Interventions
Dietary intervention
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Revere, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure

NCT00624559
View directory record Official record
Conditions
Hypertension
Interventions
celecoxib (Celebrex), Placebo
Drug · Other
Lead sponsor
University of Delaware
Other
Eligibility
22 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jan 5, 2012 · Synced Sep 23, 2026, 10:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

NCT05147909
View directory record Official record
Conditions
Physical Inactivity, Phosphate Overload, Visceral Obesity
Interventions
Sodium Phosphate, Sodium Chloride
Dietary Supplement
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 23, 2026, 10:45 PM EDT
Not listed Not applicable Interventional

Dietary Sodium-Restriction (DIS) and Renal Meals (RM) for Hemodialysis (HD)(DISaRM-HD)

NCT04991441
View directory record Official record
Conditions
Kidney Failure, Chronic, Dietary Modification
Interventions
Controlled Dietary Sodium Restriction, Control Diet & Controlled Dietary Sodium Restriction
Dietary Supplement
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pulse Biomarker Discovery

NCT04887584
View directory record Official record
Conditions
Body Weight
Interventions
Control diet, Low Pulse diet, High Pulse diet
Other
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Results available

The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy.

NCT04675775
View directory record Official record
Conditions
Cirrhosis, Ascites, Liver Diseases, Frailty, Sarcopenia, Hepatic Encephalopathy
Interventions
Medically-tailored meals (MTM), Protein supplements, Nutrition education handout
Other · Dietary Supplement · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional

Long COVID-19 Syndrome Lifestyle Intervention Study

NCT05836402
View directory record Official record
Conditions
Long COVID-19 Syndrome
Interventions
Low carbohydrate diet intervention
Dietary Supplement
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional

Geriatric Out of Hospital Randomized Meal Trial in Heart Failure

NCT02148679
View directory record Official record
Conditions
Heart Failure
Interventions
DASH/SRD, Usual care
Other
Lead sponsor
University of Michigan
Other
Eligibility
55 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
3
States / cities
Ann Arbor, Michigan • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 26, 2017 · Synced Sep 23, 2026, 10:45 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)

NCT01942395
View directory record Official record
Conditions
Diastolic Heart Failure, Hypertensive Heart Disease
Interventions
DASH/sodium-restricted diet (DASH/SRD), Control Diet
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Sep 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional

Fully Remote, Telehealth-based Ketogenic Metabolic Therapy for Long COVID

NCT07745699
View directory record Official record
Conditions
Long COVID Fatigue
Interventions
Ketogenic Metabolic Therapy, Lifestyle Intervention
Other · Behavioral
Lead sponsor
National University of Natural Medicine
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 23, 2026, 10:45 PM EDT