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ClinicalTrials.gov public records Last synced Oct 11, 2026, 9:46 AM EDT

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Showing 121–144 of 148 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: low-calorie (low-fat) diet Clear all
Not listed Not applicable Interventional

Blood Glucose Stability and Variability on Two Diets

NCT01443143
View directory record Official record
Conditions
Type 2 Diabetes, Obesity
Interventions
Portion-controlled diet, Usual Diet
Other · Dietary Supplement
Lead sponsor
Nutrisystem, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 29, 2011 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Phase 3 Interventional

Low Carbohydrate Diet Compared to Calorie and Fat Restricted Diet in Patients With Obesity and Type II Diabetes

NCT00108459
View directory record Official record
Conditions
Obesity, Type 2 Diabetes, Hyperlipidemia
Interventions
Low Carbohydrate Diet
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional Results available

ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)

NCT03651622
View directory record Official record
Conditions
Diabetes Mellitus, Type 1, Overweight and Obesity
Interventions
Hypocaloric, low carbohydrate diet, Hypocaloric, moderate low fat diet, Mediterranean diet, no caloric restriction
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
19 Years to 30 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Palo Alto, California • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 4, 2022 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cancer Dietary Objectives Study

NCT00561977
View directory record Official record
Conditions
Cancer, Heart Disease
Interventions
High Fiber Diet, low saturated fat diet, Combination diet
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
21 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 2, 2011 · Synced Oct 11, 2026, 9:46 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Groceries for Residents of Southeastern USA to Stop Hypertension

NCT06891911
View directory record Official record
Conditions
Hypertension, Elevated Blood Pressure, Cardiovascular Diseases, Dietary Intervention
Interventions
Dietitian-Assisted DASH groceries, Self-directed shopping
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional

Low Carbohydrate Diet: The Effects on Non Alcoholic Fatty Liver Disease in Obese Teens With Metabolic Syndrome

NCT02358928
View directory record Official record
Conditions
NAFLD, Fatty Liver, Obesity, Metabolic Syndrome
Interventions
Diet Intervention
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
11 Years to 17 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2022 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional Results available

Exercise and QUality Diet After Leukemia: The EQUAL Study

NCT02244411
View directory record Official record
Conditions
Adult Survivors of Childhood Leukemia
Interventions
individual diet & physical activity counselor and website through Healthways at Hopkins, self directed weight loss, questionnaires, fasting blood draw, measurement of height, weight and waist circumference, and blood pressure
Behavioral · Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
358 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
2
States / cities
New York, New York • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Weight Loss on Hepatic and Muscle Lipid Content and on Insulin Sensitivity on Obese Adolescents With NAFLD

NCT00585299
View directory record Official record
Conditions
Fatty Liver, Insulin Resistance
Interventions
Low-fat diet, Traditional diet
Other
Lead sponsor
Yale University
Other
Eligibility
10 Years to 21 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 17, 2014 · Synced Oct 11, 2026, 9:46 AM EDT
Recruiting Phase 2 Interventional

Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

NCT05082519
View directory record Official record
Conditions
B-cell Acute Lymphoblastic Leukemia, Obesity
Interventions
IDEAL2 Intervention
Behavioral
Lead sponsor
Etan Orgel
Other
Eligibility
7 Years to 25 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2032
U.S. locations
16
States / cities
Los Angeles, California • Orange, California • San Francisco, California + 13 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional

The Effect of Avocado on Cardiovascular Disease (CVD) Risk Factors

NCT01235832
View directory record Official record
Conditions
Cardiovascular Disease, Hyperlipidemia
Interventions
Avocado Diet, Lower-Fat Diet, Moderate Fat Diet
Other
Lead sponsor
Penn State University
Other
Eligibility
21 Years to 70 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional

The Lifestyle Education About Prediabetes (Leap) Study

NCT05235425
View directory record Official record
Conditions
PreDiabetes
Interventions
Standard NDPP, Very low-carbohydrate diet
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 75 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low-calorie Sweeteners and Adipose Signaling

NCT03125356
View directory record Official record
Conditions
Nutritional and Metabolic Diseases
Interventions
Diet Soda
Other
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 25 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Phase 2 Interventional Results available

Study to Determine the Effect of Food on the Absorption of an Oral Testosterone Undecanoate Formulation

NCT00924612
View directory record Official record
Conditions
Male Hypogonadism
Interventions
Oral testosterone undecanoate (containing 300 mg T)
Drug
Lead sponsor
Clarus Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years · Male only
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigating Fitness Interventions in the Elderly (INFINITE)

NCT01048736
View directory record Official record
Conditions
Obesity, Older Adults, Sedentary
Interventions
Exercise Only, Exercise + Diet
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years to 80 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 11, 2026, 9:46 AM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

SOAR-2: Intervening in Obesity Through Reduction of Dietary Branched Chain Amino Acids

NCT04424537
View directory record Official record
Conditions
Obesity, Diabetes
Interventions
Control diet, Low branched-chain amino acids(BCAA) diet, Low protein diet
Dietary Supplement
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
30 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health

NCT02706288
View directory record Official record
Conditions
Obesity, Insulin Resistance
Interventions
Weight loss with very low fat plant-based diet and regular exercise
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 8, 2022 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy Participants

NCT06378658
View directory record Official record
Conditions
Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation, Healthy Volunteers
Interventions
BAY2927088, Esomeprazole, Food
Drug · Other
Lead sponsor
Bayer
Industry
Eligibility
18 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2024 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Weight Reduction and Lifestyle Program in Older Adults

NCT00714506
View directory record Official record
Conditions
Functional Disability, Obesity, Physical Inactivity
Interventions
Diet and physical activity, Physical activity control
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years to 100 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2008
U.S. locations
1
States / cities
McKeesport, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthy Eating for Reproductive Health (HERHealth)

NCT01509066
View directory record Official record
Conditions
Polycystic Ovarian Syndrome, Infertility, Obesity, Overweight
Interventions
Diet
Other
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 18, 2019 · Synced Oct 11, 2026, 9:46 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Low Fat Diet for Fatigue in MS

NCT03322982
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Low-fat diet
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 70 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 1, 2021 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Early Phase 1 Interventional Results available

Pilot Study of Pazopanib With Low Fat Meal (PALM) in Advanced Renal Cell Carcinoma

NCT02729194
View directory record Official record
Conditions
Carcinoma, Renal Cell
Interventions
Pazopanib, Low Fat Diet
Drug · Other
Lead sponsor
University of Michigan Rogel Cancer Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Oct 11, 2026, 9:46 AM EDT
Terminated Phase 1 Interventional

A Phase 1 Study of Oprozomib to Assess Food Effect, Drug-Drug Interaction With Midazolam, and Safety and Tolerability in Patients With Advanced Malignancies

NCT02244112
View directory record Official record
Conditions
Advanced Non-Central Nervous System (CNS) Malignancies
Interventions
Oprozomib, Midazolam
Drug
Lead sponsor
Amgen
Industry
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
7
States / cities
Aurora, Colorado • Atlanta, Georgia • Detroit, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Feb 21, 2021 · Synced Oct 11, 2026, 9:46 AM EDT
Completed Not applicable Interventional

Weight Loss Intervention in Women With PCOS

NCT03677362
View directory record Official record
Conditions
Polycystic Ovary Syndrome, Overweight and Obesity
Interventions
Weight loss intervention
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years to 42 Years · Female only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Oct 11, 2026, 9:46 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Diet and Migraine Study

NCT01859052
View directory record Official record
Conditions
Migraine, Obesity
Interventions
Low carbohydrate diet, Low calorie low fat diet, AHA diet recommendations
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
19 Years to 49 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 2, 2015 · Synced Oct 11, 2026, 9:46 AM EDT