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ClinicalTrials.gov public records Last synced Sep 19, 2026, 2:04 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: lumbar decompression Clear all
Active, not recruiting Not applicable Interventional

MOTUS Total Joint Replacement Investigational Device Exemption Study

NCT05438719
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
MOTUS Total Joint Replacement
Device
Lead sponsor
3Spine
Industry
Eligibility
21 Years to 80 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
14
States / cities
Los Angeles, California • Steamboat Springs, Colorado • Deerfield Beach, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

Investigating Superion™ In Spinal Stenosis

NCT00692276
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Intermittent Claudication
Interventions
Superion™ Interspinous Spacer, X-STOP® IPD® Device
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
45 Years and older
Enrollment
391 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
32
States / cities
Phoenix, Arizona • Tucson, Arizona • Beverly Hills, California + 28 more
Source: ClinicalTrials.gov public record
Updated Nov 15, 2020 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Phase 4 Interventional Results available

MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

NCT00956631
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Interlaminar Decompression
Procedure
Lead sponsor
Vertos Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
13
States / cities
Jonesboro, Arkansas • Los Angeles, California • Napa, California + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2013 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

The STEPS - Totalis™ Trial

NCT02079038
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Totalis, Comparator Surgical Procedure
Device · Procedure
Lead sponsor
VertiFlex, Incorporated
Industry
Eligibility
55 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
19
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 16 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2020 · Synced Sep 19, 2026, 2:04 PM EDT
Not listed Phase 2 Interventional

KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion

NCT04294004
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Fusion
Interventions
TGplPTH1-34 in fibrin, Autologous Bone Graft
Combination Product · Other
Lead sponsor
Kuros Biosurgery AG
Industry
Eligibility
25 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
15
States / cities
La Jolla, California • Boulder, Colorado • Washington D.C., District of Columbia + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Sep 19, 2026, 2:04 PM EDT
Not listed Phase 3 Interventional

Randomized Trial of Intraoperative IV Versus Preoperative Oral Acetaminophen During Ambulatory Lumbar Discectomy

NCT04574778
View directory record Official record
Conditions
Pain, Postoperative, Spine Surgery
Interventions
Acetaminophen
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 11, 2024 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Not applicable Interventional

OP-1 Putty for Posterolateral Fusions

NCT00677950
View directory record Official record
Conditions
Degenerative Lumbar Spondylolisthesis
Interventions
Spinal fusion
Procedure
Lead sponsor
Olympus Biotech Corporation
Industry
Eligibility
18 Years to 85 Years
Enrollment
336 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
21
States / cities
Santa Monica, California • Stanford, California • Denver, Colorado + 18 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2011 · Synced Sep 19, 2026, 2:04 PM EDT
Suspended Not applicable Interventional

Pedicle Osteotomy for Stenosis Trial

NCT03381677
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Spondylolisthesis, Grade 1, Neurogenic Claudication
Interventions
Pedicle Lengthening Osteotomy with Altum® Device, Control
Device
Lead sponsor
Innovative Surgical Designs
Industry
Eligibility
40 Years to 80 Years
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Bryn Mawr, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 2, 2020 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Phase 2Phase 3 Interventional

Enhanced Recovery After Surgery in Orthopaedic Spine Surgery

NCT04562610
View directory record Official record
Conditions
Lumbar Surgery
Interventions
Intravenous Infusion group, All oral administration group
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 105 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 20, 2025 · Synced Sep 19, 2026, 2:04 PM EDT
Recruiting No phase listed Observational

OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults

NCT05452694
View directory record Official record
Conditions
Lumbar Spine Stenosis, Lumbar Spine Degeneration
Interventions
Not listed
Lead sponsor
OpalGenix, Inc
Industry
Eligibility
18 Years to 99 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Sep 19, 2026, 2:04 PM EDT
Not listed Not applicable Interventional

Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression

NCT01338766
View directory record Official record
Conditions
Radiculopathy, Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
Decompression using the iO-Flex® system
Procedure
Lead sponsor
Baxano Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
14
States / cities
Castro Valley, California • Los Angeles, California • Mission Viejo, California + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2014 · Synced Sep 19, 2026, 2:04 PM EDT
Withdrawn Phase 2 Interventional

Clinical Efficacy and Safety of Axiom Worldwide DRX9000 Axial Decompression System for Treatment of Low Back Pain

NCT00469118
View directory record Official record
Conditions
Low Back Pain
Interventions
DRX9000™
Device
Lead sponsor
NEMA Research, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 11, 2015 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Not applicable Interventional

Coflex PS3 Actual Conditions for Use Study

NCT02555280
View directory record Official record
Conditions
Spinal Stenosis Lumbar
Interventions
coflex® Interlaminar Technology, Decompression
Device · Procedure
Lead sponsor
Companion Spine, LLC
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
14
States / cities
Phoenix, Arizona • Sacramento, California • San Luis Obispo, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Phase 1 Interventional

Low-Dose Radiation to Prevent Complications of Back Surgery

NCT00018876
View directory record Official record
Conditions
Failed Back Surgery Syndrome, Postlaminectomy Syndrome, Postdiscectomy Epidural Fibrosis
Interventions
Lumbar nerve root decompression, Preoperative low-dose external beam radiation
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2002
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 6, 2013 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

Comparative Study of Sham Versus Mild® Procedure in Patients Diagnosed With Symptomatic Lumbar Central Canal Stenosis

NCT01129921
View directory record Official record
Conditions
Lumbar Spine Stenosis Central Canal
Interventions
Percutaneous Lumbar Decompression, Sham lumbar decompression
Device
Lead sponsor
Napa Pain Institute
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Napa, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2013 · Synced Sep 19, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional

Photobiomodulation for Lower Back Pain Post Spinal Fusion and Decompression Surgery

NCT06282770
View directory record Official record
Conditions
Spinal Fusion, Chronic Lower Back Pain
Interventions
Laser Diode Brace, Sham Laser Diode Brace
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Phase 4 Interventional

Randomized Study of Anular Repair With the Xclose Tissue Repair System

NCT00760799
View directory record Official record
Conditions
Diskectomy
Interventions
Discectomy with anular repair
Procedure
Lead sponsor
Anulex Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
34
States / cities
Huntsville, Alabama • Phoenix, Arizona • San Diego, California + 25 more
Source: ClinicalTrials.gov public record
Updated May 1, 2012 · Synced Sep 19, 2026, 2:04 PM EDT
Terminated Phase 3 Interventional Results available

DIAM™ Spinal Stabilization System vs. Decompression, Formerly vs. Posterolateral Fusion

NCT00627497
View directory record Official record
Conditions
Degenerative Lumbar Spinal Stenosis
Interventions
Single-Level Posterior Decompression, DIAM Spinal Stabilization, Fusion
Procedure · Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
35 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
9
States / cities
Fremont, California • Jacksonville, Florida • Melbourne, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2021 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of OMT on Gait Kinematics and Postural Control in Parkinson Disease

NCT04946760
View directory record Official record
Conditions
Parkinson Disease
Interventions
Sham Manipulation
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
50 Years and older
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Sep 19, 2026, 2:04 PM EDT
Active, not recruiting Not applicable Interventional

A 5-year Superion™ IDS Clinical Outcomes Post-Approval Evaluation (SCOPE)

NCT04192591
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Superion™ IDS device
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
45 Years and older
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2041
U.S. locations
23
States / cities
Carlsbad, California • Larkspur, California • Rancho Mirage, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 19, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional

A Prospective, Randomized Comparison Of Drainage Techniques After One- Or Two-Level Open Posterior Lumbar Decompression Or Decompression And Fusion

NCT06820736
View directory record Official record
Conditions
Complications, Postoperative
Interventions
Drain
Device
Lead sponsor
Twin Cities Spine Center
Other
Eligibility
18 Years to 70 Years
Enrollment
975 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2040
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 19, 2026, 2:04 PM EDT
Not yet recruiting Not applicable Interventional

Activity Post Spinal Surgery Engagement Trial

NCT07825480
View directory record Official record
Conditions
Spinal Surgery for Lumbar Spinal Stenosis (LSS)
Interventions
Wrist based activity tracker wear, Basic Study Activities, Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives
Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
40 Years to 85 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 19, 2026, 2:04 PM EDT
Active, not recruiting Not applicable Interventional

LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis

NCT03115983
View directory record Official record
Conditions
Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
LimiFlex, Fusion Instrumentation, Decompression, Fusion
Device · Procedure
Lead sponsor
Empirical Spine, Inc.
Industry
Eligibility
25 Years to 80 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
28
States / cities
Tempe, Arizona • Oakland, California • Redwood City, California + 24 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Sep 19, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vertos Mild - Post Market Patient Outcomes

NCT01076244
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Minimally Invasive Lumbar Decompression
Procedure
Lead sponsor
The Center for Pain Relief, Inc.
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 1, 2013 · Synced Sep 19, 2026, 2:04 PM EDT