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Showing 1–24 of 33 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: manual lymphatic drainage Clear all
Not listed Not applicable Interventional

The Effect of Hand Exercises on Upper Limb Volume, Quality of Life, and Hand Function in Breast Cancer Survivors

NCT05983380
View directory record Official record
Conditions
Breast Cancer Lymphedema
Interventions
Hand Mobility and Grip Strengthening Exercises, Usual Care
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
3
States / cities
Albuquerque, New Mexico • Rio Rancho, New Mexico • Santa Fe, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Sep 21, 2026, 4:56 PM EDT
Terminated Not applicable Interventional

Manual Lymph Drainage

NCT02360735
View directory record Official record
Conditions
Total Knee Arthroplasty, Post-operative Edema
Interventions
Manual Lymphatic Drainage, Physical Therapy
Other
Lead sponsor
Anne Arundel Health System Research Institute
Other
Eligibility
45 Years to 90 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Annapolis, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 8, 2018 · Synced Sep 21, 2026, 4:56 PM EDT
Enrolling by invitation Phase 1Phase 2 Interventional

Evaluation of Lymphatic Response to Physiotherapy in Patients With Swelling Associated With Superficial Venous Disease

NCT07165340
View directory record Official record
Conditions
Chronic Venous Disease
Interventions
Indocyanine Green near infrared fluorescence imaging, advanced pneumatic compression, Duplex ultrasound, compression wrap
Combination Product · Device · Diagnostic Test
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Not applicable Interventional

Establishing Guidelines for Manual Lymphatic Drainage

NCT05509062
View directory record Official record
Conditions
Lymphedema of Leg
Interventions
Pressure
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
30 Years to 75 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 10, 2024 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Not applicable Interventional Results available

Lymphedema Prophylaxis in Breast Cancer Survivors Who Show Early Evidence of High-risk Status

NCT00383500
View directory record Official record
Conditions
Lymphedema, Breast Cancer
Interventions
Flexitouch, Class 1 compression garment
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 29, 2017 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Not applicable Interventional

Physical Rehabilitation Evaluation and Optimal Physical Therapy (PRE-OPT)

NCT04225572
View directory record Official record
Conditions
Breast Cancer
Interventions
Physical Therapy: Dependent on Patient's Needs
Behavioral
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 21, 2026, 4:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Weightlessness Associated Cephalad Fluid Shifts; The Potential to Evaluate Venous and Lymphatic Dysfunction

NCT06405282
View directory record Official record
Conditions
Fluid Retention Tissue, Perfusion; Complications
Interventions
Manual Lymphatic Drainage, Near infrared spectroscopy, Temperature, Tissue Dialectic Constant
Other · Device
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 45 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Sep 21, 2026, 4:56 PM EDT
Terminated Not applicable Interventional

Flexitouch Lymphedema System in Treating Stage II Lymphedema in Patients With Breast Cancer

NCT01019512
View directory record Official record
Conditions
Breast Cancer, Lymphedema
Interventions
questionnaire administration, lymphedema management
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2015 · Synced Sep 21, 2026, 4:56 PM EDT
Recruiting Not applicable Interventional

The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema

NCT05890677
View directory record Official record
Conditions
Lymphedema, Breast Cancer
Interventions
Surgical Intervention, Conservative Complex Physical Decongestion Therapy
Procedure
Lead sponsor
University Hospital, Basel, Switzerland
Other
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2036
U.S. locations
4
States / cities
New Haven, Connecticut • Boston, Massachusetts • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Massage for Post Breast Surgery

NCT02250898
View directory record Official record
Conditions
Postmastectomy Lymphedema Syndrome, Pain, Shoulder Mobility Impairment, Breast Surgery
Interventions
Myofascial Massage Therapy, Global Relaxation Massage
Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years to 79 Years · Female only
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 16, 2018 · Synced Sep 21, 2026, 4:56 PM EDT
Recruiting Phase 2 Interventional

A Study Evaluating the Feasibility and Compliance of Manual Lymphatic Drainage Comparing Indocyanine-Green (ICG) Guided vs. Traditional Guided in Patients Undergoing Axillary Node Dissection for the Treatment of Breast Cancer

NCT06327490
View directory record Official record
Conditions
Breast Cancer
Interventions
ICG-guided manual lymphatic drainage, Traditional manual lymphatic drainage, Indocyanine green
Procedure · Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 21, 2026, 4:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Study of the Combined Effect of Low Level Laser Therapy and Manual Lymph Drainage on Reducing Body Circumference

NCT02591056
View directory record Official record
Conditions
Circumference Reduction
Interventions
Erchonia® Verju™ Laser, Green PRESS 8
Device
Lead sponsor
Erchonia Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
3
States / cities
Stockton, California • Marion, Indiana • Bloomfield Hills, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 9, 2020 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Not applicable Interventional Results available

Intermittent Pneumatic Compression in Women With Lipo-lymphedema (Lipedema With Swelling)

NCT04213989
View directory record Official record
Conditions
Lipedema, Lipolymphedema
Interventions
Flexitouch Plus and Conservative Care, Conservative Care
Device · Other
Lead sponsor
Thomas Wright, MD
Industry
Eligibility
18 Years to 70 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
O'Fallon, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 22, 2022 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Phase 4 Interventional Results available

Low Level Laser Treatment and Breast Cancer Related Lymphedema

NCT00852930
View directory record Official record
Conditions
Lymphedema
Interventions
laser and MLD combined, laser alone, manual lymphatic drainage
Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
21 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Sep 21, 2026, 4:56 PM EDT
Terminated Phase 3 Interventional Results available

Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer

NCT00577317
View directory record Official record
Conditions
Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer, Stage I Uterine Corpus Cancer, Stage I Vulvar Cancer, Stage IA Cervical Cancer, Stage IB Cervical Cancer, Stage II Uterine Corpus Cancer, Stage II Vulvar Cancer, Stage IIA Cervical Cancer, Stage IIB Cervical Cancer, Stage III Cervical Cancer, Stage III Uterine Corpus Cancer, Stage III Vulvar Cancer, Stage IV Uterine Corpus Cancer, Stage IVA Cervical Cancer, Stage IVB Cervical Cancer, Stage IVB Vulvar Cancer
Interventions
Management of Therapy Complications, Quality-of-Life Assessment
Procedure · Other
Lead sponsor
Gynecologic Oncology Group
Network
Eligibility
18 Years and older · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Phase 1 Interventional

Near-infrared Fluorescence Lymphatic Imaging Assessment of Lymphatic Response to Pneumatic Back/Neck Lymphatic Drainage Delivered by a Pneumatic Manual Lymphatic Drainage Device

NCT05946837
View directory record Official record
Conditions
Neck Pain, Back Pain
Interventions
Indocyanine green (ICG) dye, NIRF-LI imaging, Neuroglide pad
Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 13, 2023 · Synced Sep 21, 2026, 4:56 PM EDT
Recruiting Not applicable Interventional

Manual Lymphatic Drainage Breast Massage in Breast Cancer Patients After Breast Conserving Surgery

NCT06297265
View directory record Official record
Conditions
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Localized Breast Carcinoma
Interventions
Lymphedema Management, Questionnaire Administration, Adjuvant breast radiation therapy
Other · Radiation
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Not applicable Interventional

Complete Decongestive Therapy on Head and Neck Lymphedema

NCT04045860
View directory record Official record
Conditions
Lymphedema of Face, Secondary Lymphedema
Interventions
Complete Decongestive Therapy, Observation
Procedure · Other
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 7, 2021 · Synced Sep 21, 2026, 4:56 PM EDT
Withdrawn Not applicable Interventional

Blood Flow Restriction Therapy Improves Tibial Plateau Fracture Recovery

NCT06589115
View directory record Official record
Conditions
Tibial Plateau Fractures
Interventions
Blood Flow Restriction Cuff, Physical Therapy
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 21, 2026, 4:56 PM EDT
Not listed Not applicable Interventional

Lymphedema Treatment for Blunt Facial Trauma

NCT02977182
View directory record Official record
Conditions
Post-traumatic Facial Edema
Interventions
Complete Decongestive Therapy (CDT)
Other
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 29, 2016 · Synced Sep 21, 2026, 4:56 PM EDT
Active, not recruiting Phase 1 Interventional

Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer Survivorship

NCT05937269
View directory record Official record
Conditions
Lymphedema of Face, Head and Neck Cancer
Interventions
Near-infrared fluorescence lymphatic imaging, advanced pneumatic compression therapy
Combination Product · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lymphedema Progression Screening Using MRI

NCT02611557
View directory record Official record
Conditions
Lymphedema, Breast Cancer
Interventions
Manual lymphatic drainage therapy
Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 25, 2019 · Synced Sep 21, 2026, 4:56 PM EDT
Completed Not applicable Interventional Results available

Treatment of Breast Cancer-related Lymphedema With a Negative Pressure Device

NCT03252145
View directory record Official record
Conditions
Lymphedema, Secondary, Lymphedema of Upper Limb
Interventions
PhysioTouch, Manual Lymph Drainage (MLD)
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Sep 21, 2026, 4:56 PM EDT
Terminated Not applicable Interventional

Imaging Lymphatic/Cerebrospinal Fluid (CSF) Drainage From the Head and Neck in Persons With Traumatic Brain Injury: Demonstration of Feasibility and Evaluation of Manual Therapy to Improve Drainage and Facilitate Cognitive Recovery

NCT05129514
View directory record Official record
Conditions
Trauma, Brain, Neuroinflammation
Interventions
Manual Lymphatic Drainage (MLD)
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 21, 2026, 4:56 PM EDT