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ClinicalTrials.gov public records Last synced Oct 16, 2026, 5:11 AM EDT

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Showing 673–696 of 972 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: marcaine bupivacaine Clear all
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Transverse Abdominal Plane Anesthesia for Abdominal Wall Reconstruction

NCT02274077
View directory record Official record
Conditions
Hernia, Ventral
Interventions
EXPAREL, Normal Saline
Drug
Lead sponsor
Chester Mays
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2016 · Synced Oct 16, 2026, 5:11 AM EDT
Not listed Phase 4 Interventional

Laryngeal Nerve Block for Chronic Cough

NCT05292677
View directory record Official record
Conditions
Laryngeal Nerve Block, Chronic Neurogenic Cough, Laryngeal Hypersensitivity
Interventions
Steroid/Anesthesia Mixture, Placebo
Drug
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 23, 2022 · Synced Oct 16, 2026, 5:11 AM EDT
Recruiting Phase 4 Interventional

Exparel and Education to Avoid Opioids After Carpal Tunnel Release

NCT03867539
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Differing pain management strategy
Drug
Lead sponsor
Kettering Health Network
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
2
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 16, 2026, 5:11 AM EDT
Terminated Phase 4 Interventional

Use of Long-acting Bupivacaine In Lower Extremity Amputation

NCT04360421
View directory record Official record
Conditions
Amputation, Anesthesia, Local, Opioid Use
Interventions
Liposomal bupivacaine
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2023 · Synced Oct 16, 2026, 5:11 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Effect of Epidural Analgesia During Labor on Force of Maternal Push

NCT04888858
View directory record Official record
Conditions
Labor Pain, Analgesia, Maternal; Procedure
Interventions
Epidural analgesia (0.125% bupivacaine/2mcg fentanyl solution)
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Oct 16, 2026, 5:11 AM EDT
Terminated Phase 4 Interventional Results available

Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations

NCT05140499
View directory record Official record
Conditions
Pain, Postoperative, Amputation
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride 0.5 % Injectable Solution
Drug
Lead sponsor
Aurora Quaye
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Not applicable Interventional

Postoperative Pain Control Results Using Periarticular Versus Intra-capsular Injection of Bupivacaine Liposome Injectable Suspension in Total Knee Arthroplasty

NCT02166632
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Intracapsular Injection, Periarticular Injection
Procedure
Lead sponsor
Broward Health
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 10, 2016 · Synced Oct 16, 2026, 5:11 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial

NCT04115644
View directory record Official record
Conditions
Full Thickness Rotator Cuff Tear, Rotator Cuff Tendinitis
Interventions
Ketorolac, Marcaine (placebo), Kenalog
Drug
Lead sponsor
Michael Khazzam
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
2
States / cities
Baltimore, Maryland • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Oct 16, 2026, 5:11 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Use of Pre-Emptive Pudendal Nerve Block for Pelvic Reconstructive Surgery

NCT02409498
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
pudendal block, no pudendal block
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Oct 16, 2026, 5:11 AM EDT
Withdrawn Phase 4 Interventional

ABC Blocks for Cardiac Surgery

NCT05589363
View directory record Official record
Conditions
Pain
Interventions
ABC block with bupivacaine/liposomal bupivacaine, ABC block with saline
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Phase 3 Interventional Results available

Study to Evaluate Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy

NCT00744848
View directory record Official record
Conditions
Hemorrhoids
Interventions
Bupivacaine HCl, SKY0402
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
20
States / cities
Birmingham, Alabama • Montgomery, Alabama • Pasadena, California + 16 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2013 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Not applicable Interventional

Opioid-Free Orthopaedic Surgery

NCT04176783
View directory record Official record
Conditions
Pain Management
Interventions
Opioids, Opioid-Free
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
511 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Oct 16, 2026, 5:11 AM EDT
Recruiting Phase 2 Interventional

Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain

NCT04930887
View directory record Official record
Conditions
Craniofacial Pain, Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia, Sphenopalatine Ganglion Neuralgia, Paroxysmal Hemicrania
Interventions
Exparel (Bupivacaine Liposome), Saline
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Not applicable Interventional Results available

Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction

NCT02584452
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament, Tear of Anterior Cruciate Ligament
Interventions
Mepivacaine, adductor canal continuous nerve catheter, Normal Saline as bolus followed by bupivacaine, adductor canal nerve block, ropivacaine and dexamethasone, Propofol, Fentanyl
Drug · Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
14 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 11, 2019 · Synced Oct 16, 2026, 5:11 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Superior Hypogastric Nerve Plexus Block With Bupivacaine After Robotic Resection of Endometriosis

NCT06577233
View directory record Official record
Conditions
Endometriosis
Interventions
Bupivacaine Hydrochloride, Normal saline
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Not applicable Interventional Results available

Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair

NCT01500109
View directory record Official record
Conditions
Cleft Palate
Interventions
Oral acetaminophen, Ofirmev®, Opioid only
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
5 Months to 5 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Oct 16, 2026, 5:11 AM EDT
Recruiting Phase 4 Interventional

Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release

NCT07840183
View directory record Official record
Conditions
Ventral Hernia, Ventral Hernia Repair, Postoperative Pain
Interventions
Bupivicaine, Fentanyl, Thoracic epidural analgesia, Hydromorphone, Acetaminophen, Ketorolac, magnesium sulfate, Tramadol, Gabapentin, Cyclobenzaprine, transversus abdominis plane block
Drug · Device · Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Not applicable Interventional

Laparoscopic Ventral Hernia Repair With Elastomeric Pain Pump

NCT00472134
View directory record Official record
Conditions
Hernia, Ventral
Interventions
bupivacaine, On-Q PainBuster pump
Drug · Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 8, 2015 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Abdominal Nerve Blockade in Chronic Heart Failure.

NCT03453151
View directory record Official record
Conditions
Heart Failure
Interventions
splanchnic nerve anesthesia with a local anesthetic
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 24, 2020 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Epidural Catheter With or Without Adductor Canal Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty

NCT02121392
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Nerve Block
Interventions
Adductor Canal Nerve Block Catheter, Adductor Canal Nerve Block Sham Catheter, Bupivacaine
Device · Drug
Lead sponsor
University of Chicago
Other
Eligibility
Up to 85 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 20, 2020 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Early Phase 1 Interventional

Stellate Ganglion Nerve Block in Treating Women With Hot Flashes

NCT00879164
View directory record Official record
Conditions
Hot Flashes
Interventions
bupivacaine hydrochloride, questionnaire administration
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 17, 2014 · Synced Oct 16, 2026, 5:11 AM EDT
Completed Phase 4 Interventional Results available

Pec Infiltration With Liposomal Bupivacaine for Breast Surgery

NCT03599635
View directory record Official record
Conditions
Acute Pain
Interventions
liposomal bupivacaine, Bupivacaine
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Oct 16, 2026, 5:11 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

NCT06179004
View directory record Official record
Conditions
Distal Radius Fractures, Wrist Fractures
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 24, 2025 · Synced Oct 16, 2026, 5:11 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Does Ultrasound Help Junior Anesthesia Residents With Placement of Labor Analgesia in Pregnant Patients

NCT02747238
View directory record Official record
Conditions
Pregnancy
Interventions
Ultrasound, No ultrasound, Epidural infusion
Device · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 48 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2021 · Synced Oct 16, 2026, 5:11 AM EDT