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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: methadone Clear all
Not listed Not applicable Interventional

Aim 2 - Conversations Can Save Lives: TALKing About Buprenorphine & Methadone for Opioid Use Treatment Initiation

NCT06527820
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Talk About It (conversation aid)
Behavioral
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Not applicable Interventional

Motivational Program for Smokers Enrolled in a Methadone Maintenance Program

NCT00278226
View directory record Official record
Conditions
Unspecified Adult Solid Tumor, Protocol Specific
Interventions
smoking cessation intervention, educational intervention
Behavioral · Other
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
398 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 23, 2010 · Synced Sep 11, 2026, 4:15 AM EDT
Terminated Phase 2 Interventional Results available

Role of Methadone As Co-Opioid Analgesic

NCT00558870
View directory record Official record
Conditions
Pain
Interventions
Morphine, Methadone
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2016 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 4 Interventional Results available

Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome

NCT02851303
View directory record Official record
Conditions
Neonatal Abstinence Syndrome
Interventions
Morphine, Methadone
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
0 Hours to 12 Hours
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 23, 2023 · Synced Sep 11, 2026, 4:15 AM EDT
Completed No phase listed Observational

Starting Treatment With Agonist Replacement Therapies Follow-up Study

NCT01592461
View directory record Official record
Conditions
Opioid Dependence
Interventions
Not listed
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
877 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
8
States / cities
Los Angeles, California • Sacramento, California • San Francisco, California + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2016 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 1 Interventional

Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment

NCT01334580
View directory record Official record
Conditions
Chronic Pain, Opiate Dependence
Interventions
Cognitive-Behavioral Therapy for Pain and Opioid Dependence, Methadone Drug Counseling
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 2Phase 3 Interventional

Treatment for Opioid Dependent Offenders

NCT01082679
View directory record Official record
Conditions
Opioid Dependence
Interventions
Methadone, buprenorphine (Suboxone)
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 4, 2023 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 1 Interventional

Interactions of HIV Protease Inhibitors and Methadone in HIV-Infected Patients

NCT00000906
View directory record Official record
Conditions
HIV Infections
Interventions
Ritonavir, Saquinavir, Methadone hydrochloride
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2000
U.S. locations
7
States / cities
San Francisco, California • Denver, Colorado • Baltimore, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 3, 2021 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Not applicable Interventional Results available

Varenicline Smoking Cessation Treatment for Methadone Maintenance Patients

NCT01378858
View directory record Official record
Conditions
Tobacco Use Disorder, Medication Adherence
Interventions
Varenicline
Drug
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Sep 11, 2026, 4:15 AM EDT
Recruiting Phase 3 Interventional

Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement

NCT06033599
View directory record Official record
Conditions
Polysubstance Abuse, Opioid Use, Tobacco Use
Interventions
MORE and MI and NRT, MORE and No MI and NRT, Support Group and MI and NRT, Support Group and No MI and NRT
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
2
States / cities
New Brunswick, New Jersey • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 4 Interventional Results available

Methadone Versus Morphine for Orthopedic Surgery Patients

NCT00892606
View directory record Official record
Conditions
Fracture, Pain, Postoperative
Interventions
Methadone, Morphine
Drug
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 13, 2017 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Not applicable Interventional Results available

Methadone in Ambulatory Surgery

NCT02300077
View directory record Official record
Conditions
Post-operative Pain, Anesthesia
Interventions
methadone, Control (Intra-operative administration of opioids, other than methadone)
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 16, 2019 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Drug Interaction & Methadone & Buprenorphine

NCT02045693
View directory record Official record
Conditions
Hepatitis C
Interventions
Methadone, DCV 3DAA FDC, BMS-791325, Buprenorphine, Naloxone
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
3
States / cities
Anaheim, California • Philadelphia, Pennsylvania • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 16, 2014 · Synced Sep 11, 2026, 4:15 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Ketamine for OUD and Comorbid Depression (OUDCD)

NCT05051449
View directory record Official record
Conditions
Opioid Use Disorder, Depressive Disorder
Interventions
Ketamine Hydrochloride
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Sep 11, 2026, 4:15 AM EDT
Completed No phase listed Observational

The CORE Buprenorphine Project - An HIV Primary Care Program Demonstration

NCT00227357
View directory record Official record
Conditions
HIV Infections, AIDS, Opiate Dependence, Post-Traumatic Stress Disorders
Interventions
On-site - buprenorphine/naloxone (Suboxone), Off-site - methadone or no agonist
Drug
Lead sponsor
Ruth M. Rothstein CORE Center
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 6, 2010 · Synced Sep 11, 2026, 4:15 AM EDT
Recruiting Early Phase 1 Interventional

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

NCT06810336
View directory record Official record
Conditions
Brain Injury, Brain Tumors, Craniotomy Surgery, Pain, Postoperative, Postoperative Care
Interventions
Remifentanil, Methadone
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 3 Interventional Results available

Open-Label, Safety Study of Lofexidine

NCT02363998
View directory record Official record
Conditions
Opioid Withdrawal
Interventions
Lofexidine
Drug
Lead sponsor
USWM, LLC (dba US WorldMeds)
Industry
Eligibility
18 Years and older
Enrollment
286 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
18
States / cities
Little Rock, Arkansas • Springdale, Arkansas • San Diego, California + 15 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Sep 11, 2026, 4:15 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Buprenorphine/Naloxone or Methadone

NCT07314346
View directory record Official record
Conditions
Healthy Volunteer Study
Interventions
Buprenorphine/Naloxone + BEM/RZR, Methadone +BEM/RZR
Drug
Lead sponsor
Atea Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
3
States / cities
Hollywood, Florida • Overland Park, Kansas • Marlton, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 1 Interventional

Comparisons Of The Bioavailability And Pharmacodynamics Of Various Formulations Of MOA-728 In Subjects On Methadone

NCT00398502
View directory record Official record
Conditions
Metahdone-maintenance Subjects
Interventions
MOA-728
Drug
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 24, 2019 · Synced Sep 11, 2026, 4:15 AM EDT
Recruiting Not applicable Interventional

Personalized Addiction Treatment enHancement

NCT07778394
View directory record Official record
Conditions
Opioid Use Disorder, mHealth, Peer Support
Interventions
Vira Platform, Treatment-As-Usual
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
22 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 4 Interventional Results available

Smoking Cessation Treatment for Methadone Maintenance Patients

NCT01027754
View directory record Official record
Conditions
Smoking Cessation, Substance-Related Disorders
Interventions
Varenicline, Placebo
Drug
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 1Phase 2 Interventional

Medication Adherence Therapy for Opioid Abusing Pain Patients

NCT00249587
View directory record Official record
Conditions
Pain, Chronic Disease, Prescription Opioid Abuse
Interventions
Methadone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527 on Levels of Methadone (MK-8527-020)

NCT07528508
View directory record Official record
Conditions
Healthy
Interventions
MK-8527, Methadone
Drug
Lead sponsor
Merck Sharp & Dohme LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Anniston, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 11, 2026, 4:15 AM EDT
Completed Not applicable Interventional

Comparison of Two Counseling Induction Strategies

NCT01141920
View directory record Official record
Conditions
Methadone, Drug Use Disorders
Interventions
low threshold care, stepped-based care
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 16, 2015 · Synced Sep 11, 2026, 4:15 AM EDT