- Conditions
- Brain Injury, Craniocerebral Trauma
- Interventions
- cosyntropin, metyrapone
- Drug
- Lead sponsor
- National Center for Research Resources (NCRR)
- NIH
- Eligibility
- 20 Years to 35 Years
- Enrollment
- 32 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- Started 1998
- U.S. locations
- 2
- States / cities
- Galveston, Texas
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Showing 1–13
of 13
matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Cocaine Use Disorder
- Interventions
- EMB-001, EMB-001 Placebo
- Drug
- Lead sponsor
- Embera NeuroTherapeutics, Inc.
- Industry
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 82 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 4
- States / cities
- San Diego, California • Miami, Florida • Philadelphia, Pennsylvania + 1 more
- Conditions
- Cocaine Use Disorder, Tobacco Use Disorder
- Interventions
- metyrapone & oxazepam, Placebo
- Drug
- Lead sponsor
- Embera NeuroTherapeutics, Inc.
- Industry
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 24 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2016
- U.S. locations
- 2
- States / cities
- Long Beach, California • Baton Rouge, Louisiana
- Conditions
- Smoking Cessation, Tobacco Use Disorder
- Interventions
- EMB-01
- Drug
- Lead sponsor
- Rose Research Center, LLC
- Industry
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 25 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021
- U.S. locations
- 1
- States / cities
- Raleigh, North Carolina
- Conditions
- Cocaine-Related Disorders, Infusions, Intravenous
- Interventions
- Metyrapone
- Drug
- Lead sponsor
- National Institute on Drug Abuse (NIDA)
- NIH
- Eligibility
- 18 Years to 45 Years
- Enrollment
- 12 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2001 – 2002
- U.S. locations
- 1
- States / cities
- Cincinnati, Ohio
- Conditions
- Tobacco Use Disorder
- Interventions
- EMB-001
- Drug
- Lead sponsor
- Embera NeuroTherapeutics, Inc.
- Industry
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 16 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2023
- U.S. locations
- 2
- States / cities
- Miami Lakes, Florida • Raleigh, North Carolina
- Conditions
- Shift Work Schedule, Circadian Rhythm, Insulin Resistance, Circadian Misalignment
- Interventions
- Metyrapone And Hydrocortisone, Dextrose, insulin
- Drug
- Lead sponsor
- Washington State University
- Other
- Eligibility
- 18 Years to 45 Years
- Enrollment
- 48 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2029
- U.S. locations
- 1
- States / cities
- Spokane, Washington
- Conditions
- Stress
- Interventions
- Metyrapone, Dexamethasone, Cortrosyn, Corticorelin ovine triflutate
- Drug
- Lead sponsor
- University of Michigan
- Other
- Eligibility
- 18 Years to 50 Years
- Enrollment
- 256 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2012 – 2017
- U.S. locations
- 1
- States / cities
- Ann Arbor, Michigan
- Conditions
- Autonomous Cortisol Secretion, Mild Autonomous Cortisol Secretion (MACS)
- Interventions
- Metyrapone
- Drug
- Lead sponsor
- Mayo Clinic
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2028
- U.S. locations
- 1
- States / cities
- Rochester, Minnesota
- Conditions
- Cocaine Dependence, Cocaine Addiction
- Interventions
- Metyrapone, Oxazepam, Placebo
- Drug
- Lead sponsor
- Embera NeuroTherapeutics, Inc.
- Industry
- Eligibility
- 18 Years to 50 Years
- Enrollment
- 45 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2008
- U.S. locations
- 1
- States / cities
- Shreveport, Louisiana
- Conditions
- Cocaine Use Disorder
- Interventions
- Original formulation EMB-001, New formulation EMB-001
- Drug
- Lead sponsor
- Embera NeuroTherapeutics, Inc.
- Industry
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 9 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018
- U.S. locations
- 1
- States / cities
- Long Beach, California
- Conditions
- Prader Willi Syndrome, Adrenal Insufficiency
- Interventions
- Low dose (1 mcg) ACTH stimulation test, Overnight metyrapone test
- Other
- Lead sponsor
- Nationwide Children's Hospital
- Other
- Eligibility
- 2 Years and older
- Enrollment
- 23 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2014 – 2016
- U.S. locations
- 1
- States / cities
- Columbus, Ohio
- Conditions
- Cocaine Use Disorder
- Interventions
- EMB-001, Placebo, Cocaine IV, Saline IV
- Drug
- Lead sponsor
- Embera NeuroTherapeutics, Inc.
- Industry
- Eligibility
- 21 Years to 55 Years
- Enrollment
- 18 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2017
- U.S. locations
- 1
- States / cities
- Overland Park, Kansas