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Conditions: Neonatal Resuscitation, Apnea Neonatal
Interventions: Ventilator derived positive pressure ventilation - V-PPV, T-piece resuscitator (TPR); Device
Lead sponsor: Michelle Baczynski; Other
Eligibility: 25 Weeks to 29 Weeks
Enrollment: 780 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Acute Pulmonary Embolism
Interventions: Endobronchial ultrasound (EBUS); Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2028
U.S. locations: 2
States / cities: Los Angeles, California • Santa Monica, California

Conditions: Injury, Brain, Traumatic, Traumatic Brain Injury
Interventions: Airway Pressure Release Ventilation, Low Tidal Volume Ventilation; Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 14 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Bronchopulmonary Dysplasia, Neurally Adjusted Ventilatory Assist, Mechanical Ventilation
Interventions: NAVA, CMV; Device
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: Up to 24 Months
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Providence, Rhode Island

Conditions: Mechanical Ventilation Complication
Interventions: weaning; Procedure
Lead sponsor: University of California, Los Angeles; Other
Eligibility: Not listed
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Acute Respiratory Distress Syndrome
Interventions: changes in ventilator settings; Other
Lead sponsor: Respironics, California, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Respiratory Insufficiency, Infant, Newborn, Disease
Interventions: Neurally Adjusted Ventilatory Assist, Synchronized Interm. Mandatory Assist; Device
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: Up to 24 Months
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Acute Lung Injury, Adult Respiratory Distress Syndrome, Kidney Injury
Interventions: Volume-Cycled Assist-Control (AC) mode, Airway Pressure Release Ventilation (APRV) mode; Device
Lead sponsor: University of Tennessee, Chattanooga; Other
Eligibility: 18 Years to 85 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Chattanooga, Tennessee

Conditions: Respiratory Failure
Interventions: Volume Control mode, Pressure Control mode, Adaptive Pressure Control mode; Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 566 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Community-acquired Pneumonia, Influenza, COVID-19
Interventions: Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, P2Y12 inhibitor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Angiotensin Receptor Blockers, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Remdesivir, Nirmatrelvir/ritonavir + remdesivir; Drug · Other · Biological + 1 more
Lead sponsor: UMC Utrecht; Other
Eligibility: 18 Years and older
Enrollment: 20,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2028
U.S. locations: 11
States / cities: Jacksonville, Florida • Augusta, Georgia • Chicago, Illinois + 8 more

Conditions: Acute Respiratory Distress Syndrome
Interventions: ASV, Lung Protective Ventilation; Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Intracranial Hypertension, Critical Illness, Brain Injuries, Lung Injury, Respiratory Failure, Positive-Pressure Respiration, Intrinsic
Interventions: PEEP titrated mechanical ventilation; Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Respiratory Distress Syndrome
Interventions: PSV+VG mode versus SIMV+VG mode; Procedure
Lead sponsor: Children's Hospitals and Clinics of Minnesota; Other
Eligibility: 72 Hours to 120 Hours
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Acute Respiratory Distress Syndrome (ARDS), Ventilator Management, Lung-protective Ventilation, Pediatric Acute Respiratory Distress Syndrome (PARDS)
Interventions: High Driving Pressure Mechanical Ventilation, Low Driving Pressure Mechanical Ventilation; Other
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 2 Weeks to 17 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
Interventions: Automated Titration (O2matic); Device
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 4
States / cities: Aurora, Colorado • Winston-Salem, North Carolina • Portland, Oregon + 1 more

Conditions: Acute Respiratory Failure, Anxiety
Interventions: Dexmedetomidine; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Complication of Ventilation Therapy
Interventions: Not listed
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Blood Pressure, Critical Illness, Hypovolemia
Interventions: Ventilator mode change, Monitoring of blood pressure variation; Other · Device
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Bronchiolitis
Interventions: Standard Non-Invasive Mechanical Servo Ventilation, Neurally-Adjusted Ventilatory Assistance (NAVA) Non-Invasive Mechanical Servo Ventilation; Device
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 0 Years to 2 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: ARDS, Critical Illness, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
Interventions: Default order set, Physician-targeted accountable justification, Respiratory therapist (RT)-targeted accountable justification; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 99 Years
Enrollment: 7,342 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 5
States / cities: Plainsboro, New Jersey • Philadelphia, Pennsylvania • West Chester, Pennsylvania

Conditions: Prediction of Extubation Readiness
Interventions: Cardiorespiratory signal acquisition; Other
Lead sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre; Other
Eligibility: Not listed
Enrollment: 266 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 2
States / cities: Detroit, Michigan • Providence, Rhode Island

Conditions: Ventilation
Interventions: New ventilator, control ventilator; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 1,125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Moderated-high Risk of Postoperative Pulmonary Complication, Abdominal Surgery Expected More Than Two Hours
Interventions: Alveolar recruitment maneuver, Calculation of optimal PEEP, Postoperative CPAP; Procedure
Lead sponsor: Fundación para la Investigación del Hospital Clínico de Valencia; Other
Eligibility: 18 Years and older
Enrollment: 920 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Bariatric Surgery
Interventions: Pressure controlled ventilation, Volume controlled ventilation, PRVC ventilation; Other
Lead sponsor: Joseph D. Tobias; Other
Eligibility: 14 Years to 20 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Columbus, Ohio

Search by objective public record fields.

Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates

Pilot Study to Evaluate the Role of EBUS in the Diagnosis of Acute PE in Critically Ill Patients

Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury

NAVA vs. CMV Crossover in Severe BPD

Mechanical Ventilator Weaning in Chronically Ventilated Patients

Noninvasive Estimation of Work of Breathing

Randomized Crossover of NAVA and Synchronized Intermittent Pressure Ventilation in Neonates and Infants

Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation

Mode Of Ventilation During Critical IllnEss Pilot Trial

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Adaptive Support Ventilation in Acute Respiratory Distress Syndrome

Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure

Effects of Volume Guarantee With Pressure Supported vs. Synchronized Intermittent Mandatory Ventilation in VLBW Infants

Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial

Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention

Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients

Effect of Mode of Transport Ventilation on Respiratory Parameters After Cardiac Surgery

Influence of Mechanical Ventilation Mode on Arterial Pressure Variations- a Pilot Study

Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis

Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study

Prediction of Extubation Readiness in Extreme Preterm Infants by the Automated Analysis of CardioRespiratory Behavior

ADHERE-LPV Advancing Delivery of High-Quality Evidence-Based Respiratory Efforts in Lung-Protective Ventilation

Individualized Perioperative Open Lung Ventilatory Strategy

Modes of Ventilation During Laparoscopic Bariatric Surgery