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ClinicalTrials.gov public records Last synced Nov 4, 2026, 10:03 AM EST

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Showing 1–16 of 16 matching trials from the local directory fallback.

Filters: Intervention: n-acetylcysteine Clear all

Conditions: Autism Spectrum Disorder
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Stanford University; Other
Eligibility: 3 Years to 12 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2029
U.S. locations: 1
States / cities: Stanford, California

Conditions: Pilon Fracture
Interventions: N-acetylcysteine, Saline; Drug
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: IBS (Irritable Bowel Syndrome), IBS-D (Diarrhea-predominant)
Interventions: Placebo, RNIB21 containing rifaximin 132mg + N-acetylcysteine 560mg three times daily, rifaximin 66mg + N-acetylcysteine 560mg three times daily; Drug
Lead sponsor: Mark Pimentel, MD; Other
Eligibility: 18 Years and older
Enrollment: 225 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Mild Depression
Interventions: Mindfulness-based cognitive therapy, N-acetylcysteine, Placebo, Sham mindfulness-based intervention; Behavioral · Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 15 Years to 24 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Essential Thrombocythemia, MPN, Myelofibrosis, Myeloproliferative Neoplasm, Polycythemia Vera
Interventions: N-Acetylcysteine; Drug
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 2
States / cities: Irvine, California • Orange, California

Conditions: Mitochondrial Disease
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Michio Hirano, MD; Other
Eligibility: 18 Years to 80 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Chronic Postsurgical Pain, Osteoarthritis, Knee, Total Knee Arthroplasty
Interventions: GlyNAC (combination of glycine and n-acetylcysteine), Placebo; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 50 Years and older
Enrollment: 148 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Lymphoma
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 7
States / cities: Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more

Conditions: Alzheimer Disease
Interventions: Alanine, Glycine, N-acetylcysteine; Dietary Supplement
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 55 Years to 85 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Mild Cognitive Impairment
Interventions: Alanine, Glycine, N-acetylcysteine (NAC); Dietary Supplement
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 55 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Retinitis Pigmentosa
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 485 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2030
U.S. locations: 24
States / cities: Davis, California • Los Angeles, California • San Francisco, California + 21 more

Conditions: Atrial Fibrillation in High Risk Patients, Thoracic Surgery
Interventions: Amiodarone, N-Acetylcysteine, Placebo; Drug
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 184 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 9
States / cities: St Louis, Missouri • Basking Ridge, New Jersey • Middletown, New Jersey + 6 more

Conditions: Covid-19
Interventions: N-acetylcysteine, Peripheral Blood; Drug · Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Obstructive Sleep Apnea
Interventions: N-acetylcysteine (NAC), Placebo, Positive Airway Pressure (PAP) Therapy; Dietary Supplement · Procedure
Lead sponsor: NYU Langone Health; Other
Eligibility: 55 Years to 75 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Systemic Lupus Erythematosus
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 18 Years and older
Enrollment: 290 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2028
U.S. locations: 12
States / cities: Los Angeles, California • New Haven, Connecticut • Atlanta, Georgia + 8 more

Conditions: Hysterectomy
Interventions: IV N-acetylcysteine, IV Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Search by objective public record fields.

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Single-dose

Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC)

Efficacy of Rifaximin With NAC in IBS-D

Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth

An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

A Study of N-Acetylcysteine (N-AC) in People Receiving CAR T-cell Therapy for Lymphoma

Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease

Glutathione in Mild Cognitive Impairment

Oral N-acetylcysteine for Retinitis Pigmentosa

Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery

A Study of N-acetylcysteine in Patients With COVID-19 Infection

Obstructive Sleep Apnea (OSA) and Sex-Specific Responses to N-acetylcysteine (NAC)

Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine

NAC vs Placebo on Opioid Use for Hysterectomy