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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: nVNS Clear all
Completed Not applicable Interventional Results available

Non-Invasive Neurostimulation For the Relief of Symptoms Associated With Migraine

NCT01532830
View directory record Official record
Conditions
Migraine
Interventions
n-VNS
Device
Lead sponsor
ElectroCore INC
Industry
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
3
States / cities
San Francisco, California • New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2018 · Synced Sep 5, 2026, 8:28 PM EDT
Recruiting Not applicable Interventional

Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)

NCT07523685
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder PTSD, PTSD - Post Traumatic Stress Disorder, Post Traumatic Stress Disorder, Post Traumatic Stress Disorders, Post-traumatic Stress Disorder (PTSD), Post-Traumatic Stress Disorder, PTSD
Interventions
non-invasive vagus nerve stimulation
Device
Lead sponsor
Acacia Clinics
Industry
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Sunnyvale, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Phase 1 Interventional Results available

Non-invasive Vagal Nerve Stimulation in Alcohol Use Disorder

NCT05226130
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Cervical transcutaneous vagus nerve stimulation (active comparator), Cervical transcutaneous vagus nerve stimulation (sham comparator)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 65 Years · Male only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Not applicable Interventional Results available

Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress

NCT04935697
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Traumatic Brain Injury
Interventions
nVNS, SOC
Device · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
12 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS)

NCT06268288
View directory record Official record
Conditions
Postural Tachycardia Syndrome, Autonomic Dysfunction, Postural Orthostatic Tachycardia Syndrome, POTS - Postural Orthostatic Tachycardia Syndrome
Interventions
GammaCore intervention, STEPS management protocol
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
12 Years to 19 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
2
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 5, 2026, 8:28 PM EDT
Terminated Not applicable Interventional Results available

Non-invasive Vagus Nerve Stimulation (nVNS) in Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT03772717
View directory record Official record
Conditions
Chronic Inflammatory Demyelinating Polyneuropathy
Interventions
Non-invasive vagus nerve stimulation (nVNS), Standard of care treatment
Device · Other
Lead sponsor
Emory University
Other
Eligibility
5 Years to 21 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Vagal Nerve Stimulation to Probe Inflammation and Brain in Post-traumatic Stress

NCT03858985
View directory record Official record
Conditions
Post-traumatic Stress
Interventions
Cervical Transcutaneous Vagus Nerve Stimulation (Active Comparator), Cervical Transcutaneous Vagus Nerve Stimulation (Sham Comparator)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 65 Years · Male only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Sep 5, 2026, 8:28 PM EDT
Terminated Not applicable Interventional Results available

Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms

NCT04382391
View directory record Official record
Conditions
COVID, Corona Virus Infection, Respiratory Failure, Respiratory Distress Syndrome, Adult, ARDS, Human, SARS (Severe Acute Respiratory Syndrome)
Interventions
gammaCore® Sapphire (non-invasive vagus nerve stimulator), Standard of care therapies
Device · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Sep 5, 2026, 8:28 PM EDT
Recruiting Not applicable Interventional

Vagal Nerve Stimulation in mTBI

NCT04437498
View directory record Official record
Conditions
PTSD, mTBI
Interventions
sham stimulation, nVNS
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Not applicable Interventional Results available

Neurostimulation for the Relief of Acute Bronchoconstriction

NCT00762931
View directory record Official record
Conditions
Asthma
Interventions
Resolve Stimulator and Proximity Lead
Device
Lead sponsor
ElectroCore INC
Industry
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
6
States / cities
Chicago, Illinois • Detroit, Michigan • Royal Oak, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated May 14, 2018 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Not applicable Interventional Results available

Non-invasive Vagal Nerve Stimulation (nVNS) for Symptomatic Exacerbation of Nausea in Patients With Gastroparesis and Related Disorders

NCT04857281
View directory record Official record
Conditions
Chronic Unexplained Nausea and Vomiting, Gastroparesis
Interventions
nVNS (gammaCore)
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Not applicable Interventional Results available

Non-Invasive Neurostimulation for the Prevention of Chronic Migraine

NCT01667250
View directory record Official record
Conditions
Chronic Migraine
Interventions
GammaCore Active Device, GammaCore Sham Device
Device
Lead sponsor
ElectroCore INC
Industry
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
6
States / cities
San Francisco, California • Ann Arbor, Michigan • Springfield, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Sep 5, 2026, 8:28 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study

NCT06804109
View directory record Official record
Conditions
Vaping
Interventions
Active nVNS, Control nVNS
Device
Lead sponsor
Temple University
Other
Eligibility
18 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 5, 2026, 8:28 PM EDT
Not yet recruiting Phase 2 Interventional

nVNS, CBD, and SoC for Persistent Post-Traumatic Headache

NCT07624279
View directory record Official record
Conditions
Persistent Post Traumatic Headache
Interventions
Non-Invasive Vagus Nerve Stimulation, Cannabidiol, Standard of Care
Device · Drug
Lead sponsor
American Society of Pain and Neuroscience, Inc.
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
8
States / cities
Scottsdale, Arizona • Los Angeles, California • Washington D.C., District of Columbia + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Not applicable Interventional Results available

Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache

NCT01792817
View directory record Official record
Conditions
Cluster Headache
Interventions
GammaCore, Sham GammaCore device
Device
Lead sponsor
ElectroCore INC
Industry
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
20
States / cities
Santa Monica, California • Stanford, California • Englewood, Colorado + 17 more
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 5, 2026, 8:28 PM EDT
Recruiting Not applicable Interventional

Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage

NCT05103566
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal
Interventions
gammaCore
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Not applicable Interventional Results available

Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage

NCT04126408
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal
Interventions
gammaCore
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV

NCT04353778
View directory record Official record
Conditions
HIV, Non-HIV, Vagus Nerve Dysfunction
Interventions
Pyridostigmine, Placebos, non-invasive vagal nerve stimulation
Drug · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
215 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Not applicable Interventional Results available

Vagus Nerve Stimulation: Treatment for Gulf Veterans With Gulf War Illness

NCT02791893
View directory record Official record
Conditions
Pain, Migraine
Interventions
VNS device, Inactive device
Device
Lead sponsor
Benjamin Natelson
Other
Eligibility
42 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
4
States / cities
East Orange, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated May 2, 2021 · Synced Sep 5, 2026, 8:28 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease

NCT07226284
View directory record Official record
Conditions
PARKINSON DISEASE (Disorder), Parkinson's Disease (PD)
Interventions
Vagal nerve stimulation, No intervention
Device · Other
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 76 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 5, 2026, 8:28 PM EDT
Recruiting Not applicable Interventional

Effects of Vagus Nerve Stimulation on Temporomandibular Disorders.

NCT07288411
View directory record Official record
Conditions
TMD, Temporomandibular Disorders (TMDs)
Interventions
nVNS Treatment
Device
Lead sponsor
Arpana Church
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 5, 2026, 8:28 PM EDT
Completed Phase 1 Interventional

Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury

NCT02974959
View directory record Official record
Conditions
Traumatic Brain Injury, Acute Brain Injuries
Interventions
gammaCore active device, gammaCore sham device
Device
Lead sponsor
CentraCare
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Sep 5, 2026, 8:28 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena.

NCT03869008
View directory record Official record
Conditions
Raynaud Phenomenon, Primary Raynaud Phenomenon, Raynaud Disease, Raynaud Syndrome
Interventions
gammaCore Sapphire, Sham Device
Device
Lead sponsor
University of Toledo Health Science Campus
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Sep 5, 2026, 8:28 PM EDT
Recruiting Not applicable Interventional

Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder

NCT06399653
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Cervical transcutaneous vagus nerve stimulation (active comparator), Cervical transcutaneous vagus nerve stimulation (sham comparator)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 5, 2026, 8:28 PM EDT