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Conditions: Local Anesthetic
Interventions: Ropivacaine, Mepivacaine; Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 70 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Rotator Cuff Tears, Shoulder Pain
Interventions: Liposomal bupivacaine, Bupivacaine Hcl 0.5% Inj, Ropivacaine 0.5% Injectable Solution, Dexamethasone; Drug
Lead sponsor: Hospital for Special Surgery Florida; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: West Palm Beach, Florida

Conditions: Traumatic Femur Fracture
Interventions: Ropivicaine, Epinephrine; Drug
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: Up to 18 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Pain, Postoperative
Interventions: Active Comparator, Placebo Comparator; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Postoperative Pain, Hip Arthroscopy
Interventions: Preop PENG block, Placebo block, Ropivacaine 0.5% Injectable Solution, Normal Saline; Procedure · Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Frozen Shoulder
Interventions: Interscalene block with nerve catheter; Procedure
Lead sponsor: OAD Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Warrenville, Illinois

Conditions: Other Reconstructive Surgery
Interventions: Ropivacaine, Clonidine; Drug
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: Up to 21 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Laparoscopic Myomectomy, Quadratus Lumborum Nerve Block
Interventions: Ropivacaine injection, Sham treatment; Drug · Procedure
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older · Female only
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Sciatica Acute
Interventions: nerve block with ropivacaine, Standard medical treatment; Procedure · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Postural Tachycardia Syndrome
Interventions: Stellate ganglion block, Sham injection of saline, Ropivacaine, Normal saline; Procedure · Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Stanford, California

Conditions: Knee Osteoarthritis, Arthritis Knee
Interventions: ZYNRELEF 400Mg-12Mg Extended-Release Solution, Ultrasound-Guided Adductor Canal Block, Ropivacaine 0.5% Injectable Solution; Drug · Procedure
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Anterior Cruciate Ligament Tear, Knee Meniscus Tear
Interventions: Femoral Nerve Block, Adductor Canal Nerve Block, preoperative Femoral Nerve Block using 20ml of 0.5% ropivacaine, Preoperative Adductor canal block with 0.75%% ropivacaine 13.3ml.; Procedure · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Amputation
Interventions: Ropivacaine 0.2% + nerve stimulator set, Ropivacaine 0.2%; Device · Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 3
States / cities: Stanford, California • Jacksonville, Florida • Iowa City, Iowa

Conditions: Cleft Palate Children
Interventions: Ultrasound-guided bilateral suprazygomatic maxillary nerve block, Local anesthetic infiltration of the palate; Procedure
Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago; Other
Eligibility: 9 Months to 2 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Breast Surgery
Interventions: Erector Spinae (single injection), Paravertebral (single injection); Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: San Diego, California

Conditions: Shoulder Surgery, Shoulder Pain, Shoulder Injuries, Shoulder Arthritis, Shoulder Disease, Rotator Cuff Tears, Rotator Cuff Injuries, Rotator Cuff Arthropathy of Left Shoulder, Rotator Cuff Arthropathy of Right Shoulder, Rotator Cuff Repair
Interventions: Ultrasound, Ropivacaine, Bupivacaine, MediPines AGM100 Advanced Respiratory Monitoring System; Diagnostic Test · Drug · Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Pain, Osteoarthritis
Interventions: Canal Block and Capsular Injection, Femoral Nerve Block with Tibial Nerve Block; Procedure
Lead sponsor: Trinity Health Of New England; Other
Eligibility: 18 Years to 80 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Postoperative Pain, Shoulder Arthritis
Interventions: Liposomal Bupivacaine Infiltration, Continuous Perineural Ropivicaine Infusion; Drug
Lead sponsor: Eric Shepard; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pain, Postoperative
Interventions: Pre-operative Ultrasound FICB Group, Intra-operative FICB Group; Procedure
Lead sponsor: Randy Fayne, DO; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Anesthesia, Local, Phrenic Nerve Paralysis, Upper Extremity Injury, Shoulder Injury
Interventions: Interscalene brachial plexus nerve block, Erector spinae plane block; Procedure
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Pain, Postoperative, Hip Pain Chronic
Interventions: Peri-capsular Nerve Group (PENG), Lumbar Plexus Block (LPB); Drug · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 90 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Pain, Postoperative
Interventions: Intrathecal morphine sulfate (ITM), Bupivacaine hydrochloride, ropivacaine hydrochloride; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older · Female only
Enrollment: 3 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 2
States / cities: Houston, Texas

Conditions: Surgical Procedure, Unspecified, Pain, Postoperative
Interventions: Ropivacaine; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Postoperative Pain
Interventions: Bilateral erector spinae blocks using ropivacaine; Drug
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 2 Years to 17 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

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Ultrasound Guided Supraclavicular Nerve Block

Liposomal Bupivacaine Plus Bupivacaine Peripheral Nerve Blockade Versus Ropivacaine Plus Dexamethasone Peripheral Nerve Blockade for Arthroscopic Rotator Cuff Repair

Femoral Nerve Block for Femur Fracture Repair in Pediatrics

Quadratus Lumborum Block for Total Hip Arthroplasty

PENG Block for Arthroscopic Hip Surgery

Indwelling Interscalene Nerve Catheters in Surgical Management of Idiopathic Adhesive Capsulitis

Clonidine in Femoral Nerve Block Surgery in Children

Quadratus Lumborum Nerve Blocks for Myomectomies

Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care

Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome

Zynrelef Versus Adductor Canal Block

Adductor Canal Block Versus Femoral Block on Pain and Quadriceps Strength

Combined Local Anesthetic Blockade and Neuromodulation vs Local Anesthetic Blockade Only for Analgesia After Below-knee Amputation: RCT

Suprazygomatic Maxillary Nerve Block in Cleft Palate Outcomes

Erector Spinae Versus Paravertebral Nerve Blocks for Breast Surgery

Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block

Early Ambulation After Adductor Canal Block for Total Knee Arthroplasty

Liposomal Bupivacaine Infiltration vs Continuous Perineural Ropivacaine Infusion for Post-operative Pain After Total Shoulder Arthroplasty

Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery

Erector Spinae Plane Versus Interscalene Blocks for Shoulder Surgery

PENG Block Versus LP Block for THA Postop Pain

A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain

Continuous Infusions vs Scheduled Bolus Infusions

Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management