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Showing 1–24 of 86 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: no gum Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Instructed Dental Flossing on Interdental Gingival Bleeding: A Randomized Controlled Clinical Trial

NCT04218994
View directory record Official record
Conditions
Gingival Inflammation
Interventions
Flossing technique
Other
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 5, 2020 · Synced Sep 3, 2026, 2:37 PM EDT
Withdrawn Not applicable Interventional

The Effect of Gum Chewing on Postoperative Ileus

NCT00879294
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
Motion sickness wristband, Chewing Gum
Device · Dietary Supplement
Lead sponsor
Wake Forest University
Other
Eligibility
6 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional Results available

Smoking Cessation Using Motivational Therapy and Varenicline

NCT00701896
View directory record Official record
Conditions
Smoking, HIV Infections
Interventions
Varenicline tartrate, Nicotine Replacement Therapy, Biological Control, Motivational Interview
Drug · Other · Behavioral
Lead sponsor
Philip Diaz
Other
Eligibility
18 Years and older
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Sep 3, 2026, 2:37 PM EDT
Terminated Phase 4 Interventional Results available

Nicotine Gum Recovery After Colorectal Surgery

NCT01662115
View directory record Official record
Conditions
Post-operative Ileus
Interventions
Nicotine gum, Regular chewing gum
Drug · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional

Dietary Nitrate Functional Gum Effect on Gingivitis and Heart Health

NCT06029283
View directory record Official record
Conditions
Gingivitis, Cardiovascular Diseases, Gingival Diseases, Gingival Bleeding, Periodontal Diseases
Interventions
dietary nitrate, Placebo chewing gum
Dietary Supplement · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional

A Study to Evaluate Chitosan Chewing Gum in Patients With Chronic Kidney Disease

NCT01475760
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
K2CG chewing gum (20mg chitosan), K2CG chewing gum (60mg chitosan)
Other
Lead sponsor
Denver Nephrologists, P.C.
Other
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
4
States / cities
Tempe, Arizona • Denver, Colorado • Meridian, Idaho + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2012 · Synced Sep 3, 2026, 2:37 PM EDT
Active, not recruiting Not applicable Interventional

Impact of Chewing Gum on Bowel Preparation in Patients Undergoing Colonoscopy

NCT07320989
View directory record Official record
Conditions
Colon Cancer Screening
Interventions
Chewing Sugar-Free Gum During Bowel Preparation, Standard Bowel Prep (2L PEG-ELP), Standard Bowel Prep
Behavioral · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
45 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Active Reminders and Motivational Techniques on Oral Hygiene and Gingival Health in Orthodontic Patients

NCT03841825
View directory record Official record
Conditions
Oral Hygiene, White Spot Lesion, Gingivitis
Interventions
Oral hygiene instructions
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
11 Years to 20 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 9, 2020 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Methods Project 4: Clinical Trial - Amended

NCT03111537
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Cigarettes, E-Cigarette, Nicotine Gum or Lozenge
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
3
States / cities
Minneapolis, Minnesota • Buffalo, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 3, 2026, 2:37 PM EDT
Recruiting No phase listed Observational

Clinical Safety Guidelines for Managing Distal Shoe Complications

NCT07410442
View directory record Official record
Conditions
Premature Loss of Primary Molars, Space Maintainer, Soft Tissue Inflammation
Interventions
Standard Clinical Practice Regimen
Other
Lead sponsor
University of Florida
Other
Eligibility
3 Years to 9 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of PeakATP on Mood, Reaction Time and Cognition

NCT05100589
View directory record Official record
Conditions
Cognitive Change, Mood
Interventions
PeakATP, Placebo
Dietary Supplement
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 3, 2026, 2:37 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Detection of Oral and Throat Cancers Using OralViome Cancer Testing System

NCT05451303
View directory record Official record
Conditions
Oral Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma, Premalignant Lesion
Interventions
OralViome Cancer Testing System
Device
Lead sponsor
Viome
Industry
Eligibility
18 Years and older
Enrollment
475 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Real-Time Caffeine Optimization During Total Sleep Deprivation

NCT04399083
View directory record Official record
Conditions
Caffeine, Sleep Deprivation, Shift-Work Related Sleep Disturbance
Interventions
Caffeine
Dietary Supplement
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 39 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks

NCT04050722
View directory record Official record
Conditions
Gingivitis
Interventions
Sensodyne Repair and Protect, Colgate Cavity Protection
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers

NCT03233737
View directory record Official record
Conditions
No Disease State or Condition
Interventions
One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P
Combination Product · Device
Lead sponsor
Cetylite Industries
Industry
Eligibility
18 Years to 75 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Post-operative Sore Throat and Gum Chewing

NCT04859101
View directory record Official record
Conditions
Anesthesia, Surgery
Interventions
Gum, Control
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Phase 4 Interventional Results available

Identifying Optimal Smoking Cessation Intervention Components (Cessation)

NCT01116986
View directory record Official record
Conditions
Smoking, Smoking Cessation, Nicotine Dependence
Interventions
Counseling before quit attempt, Minimal In-person counseling during quit attempt, Intensive in-person counseling during the quit attempt, Minimal phone counseling during the quit attempt, Intensive phone counseling during the quit attempt, Long Term Nicotine Patch+ Nicotine Gum During Quit Attempt, Short Term Nicotine Patch + Nicotine Gum during the quit attempt, Pre-Quit Nicotine Gum, Pre-Quit Nicotine Patch, Pre-Quit Nicotine Patch + Pre-Quit Nicotine Gum
Behavioral · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
637 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 10, 2015 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional

Does Chewing Gum Hasten Return of Bowel Function Post-Operatively in Patients Undergoing Spinal Surgery

NCT02186717
View directory record Official record
Conditions
Return of Bowel Function Following Spinal Surgery
Interventions
Chewing gum
Dietary Supplement
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 90 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Phase 4 Interventional Results available

Long-term Safety of Minocycline in Patients With Gum Disease

NCT00668746
View directory record Official record
Conditions
Periodontitis
Interventions
Minocycline HCl microspheres
Drug
Lead sponsor
OraPharma
Industry
Eligibility
25 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 11, 2011 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking Cessation for Young Adult Pacific Islanders: Motivating Pacifika Against Cigarettes and Tobacco

NCT03238456
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Smoking, Smoking Cessation, Smoking, Cigarette
Interventions
Motivating Pacifika Against Cigarettes and Tobacco
Behavioral
Lead sponsor
Claremont Graduate University
Other
Eligibility
18 Years to 30 Years
Enrollment
278 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
2
States / cities
Claremont, California • Fullerton, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2017 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficiency of Piezotome-Corticision Assisted Orthodontics

NCT02026258
View directory record Official record
Conditions
Mandibular Anterior Crowding, Piezocision, Pain Perception
Interventions
Piezotome-Corticision, Orthodontics
Procedure · Device
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 6, 2017 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Phase 4 Interventional Results available

Evaluation of Treatments to Improve Smoking Cessation Medication Adherence

NCT01120704
View directory record Official record
Conditions
Smoking, Smoking Cessation, Adherence, Nicotine Dependence, Motivation
Interventions
Short Term Combination Nicotine Replacement Therapy (patch + gum), Long Term Combination Nicotine Replacement Therapy (patch + gum), Intensive Maintenance Counseling, Cognitive Medication Adherence Counseling (CAM), Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Automated Adherence Prompting Phone Calls
Drug · Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
544 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 10, 2015 · Synced Sep 3, 2026, 2:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness

NCT07053969
View directory record Official record
Conditions
Dental Implantation, Missing Teeth, Periodontitis, Adult, Mucositis
Interventions
Enamel Matrix Derivative
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 18 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 3, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

QuitAid Pilot Feasibility Trial

NCT05649241
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine patch, Nicotine gum, Medication Therapy Management
Drug · Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 13, 2022 · Synced Sep 3, 2026, 2:37 PM EDT