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ClinicalTrials.gov public records Last synced Oct 9, 2026, 5:40 AM EDT

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Showing 49–72 of 93 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: non-invasive vagal nerve stimulation Clear all
Completed Not applicable Interventional Results available

Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage

NCT04126408
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal
Interventions
gammaCore
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 9, 2026, 5:40 AM EDT
Completed Phase 1 Interventional

Vagus Nerve Stimulation for Treating Adults With Severe Fibromyalgia

NCT00294281
View directory record Official record
Conditions
Fibromyalgia
Interventions
Vagus Nerve Stimulation (VNS) Therapy
Device
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
21 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 20, 2011 · Synced Oct 9, 2026, 5:40 AM EDT
Enrolling by invitation Not applicable Interventional

taVNS for Speech and Language Recovery in Aphasia

NCT07563387
View directory record Official record
Conditions
Aphasia, Apraxia of Speech
Interventions
taVNS, sham taVNS
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study

NCT06804109
View directory record Official record
Conditions
Vaping
Interventions
Active nVNS, Control nVNS
Device
Lead sponsor
Temple University
Other
Eligibility
18 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS)

NCT06268288
View directory record Official record
Conditions
Postural Tachycardia Syndrome, Autonomic Dysfunction, Postural Orthostatic Tachycardia Syndrome, POTS - Postural Orthostatic Tachycardia Syndrome
Interventions
GammaCore intervention, STEPS management protocol
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
12 Years to 19 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
2
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 9, 2026, 5:40 AM EDT
Recruiting Not applicable Interventional

ME/CFS Brain Fog: Cognitive Rehabilitation Trial

NCT07523113
View directory record Official record
Conditions
ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis, ME/CFS Following COVID-19, Chronic Fatigue, Chronic Fatigue Syndrome (CFS), Brain Fog, Cognitive Impairment, Cognitive Dysfunction
Interventions
Processing Speed Training, In-session Instrumental Activities of Daily Living Training, Transfer Package, Follow Up Phone Calls, Trans-auricular Vagus Nerve Stimulation: High Intensity, In-session Brain Health Training, Reaction Time Training, Trans-auricular Vagus Nerve Stimulation: Low Intensity
Behavioral · Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Not yet recruiting Not applicable Interventional

Auricular Vagal Neuromodulation for Depression and Anxiety in Substance Use Disorder

NCT07814755
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation
Device
Lead sponsor
Daisy Thompson-Lake
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Recruiting Not applicable Interventional

EEG Changes and DNA Markers Related to taVNS in Stroke Patients: a Preliminary Study

NCT06226493
View directory record Official record
Conditions
Stroke
Interventions
Transcutaneous vagus nerve stimulation
Device
Lead sponsor
Casa Colina Hospital and Centers for Healthcare
Other
Eligibility
18 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Not yet recruiting Not applicable Interventional

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

NCT06723743
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients
Interventions
Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
Other · Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
25 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Vagal Nerve Stimulation to Reduce Inflammation and Hyperadrenergia

NCT02983266
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
InTENsity MicroCombo
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Oct 9, 2026, 5:40 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Non-invasive Nerve Stimulation and Sleep

NCT04021537
View directory record Official record
Conditions
PTSD
Interventions
non-invasive nerve stimulation
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 55 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Completed Not applicable Interventional

taVNS to Reduce PTSD Symptoms in WTC Responders

NCT05212714
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
taVNS
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Apr 3, 2024 · Synced Oct 9, 2026, 5:40 AM EDT
Not yet recruiting Not applicable Interventional

Vagus Nerve Stimulation on Improving Sleep in Inpatient Rehab for Post-Acute Stroke

NCT07858656
View directory record Official record
Conditions
Stroke, Ischemic Cerebrovascular Accident, Ischemic Stroke, Vagal Nerve Stimulation
Interventions
transauricular Vagal Nerve Stimulation, Sham Comparator
Device
Lead sponsor
Casa Colina Hospital and Centers for Healthcare
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Completed Not applicable Interventional Results available

Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress

NCT04935697
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Traumatic Brain Injury
Interventions
nVNS, SOC
Device · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
12 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Recruiting Not applicable Interventional

Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage

NCT05103566
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal
Interventions
gammaCore
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Recruiting Not applicable Interventional

The Path Study: Cognitive and Inflammation Targeted Gut-brain Interventions in Alcohol; Probiotics, Alcohol, Transcutaneous Vagus Nerve Stimulation, and HIV Study

NCT05090267
View directory record Official record
Conditions
Cognition, Gut Microbiome
Interventions
Probiotic Supplement, Transcutaneous Vagal Nerve Stimulation (tVNS)
Dietary Supplement · Device
Lead sponsor
University of Florida
Other
Eligibility
35 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Completed Not applicable Interventional Results available

Combining VNS With PT Interventions for Individuals With PD

NCT05871151
View directory record Official record
Conditions
Parkinson Disease
Interventions
taVNS, Exercise
Device · Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
35 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 9, 2026, 5:40 AM EDT
Completed Not applicable Interventional

Sustained Auricular Nerve Stimulation for PVC Suppression

NCT07093034
View directory record Official record
Conditions
Premature Ventricular Complexes, PVC - Premature Ventricular Contraction, Auricular Vagus Nerve Stimulation
Interventions
Extended nocturnal use of auricular vagus nerve stimulator device
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Recruiting Phase 2Phase 3 Interventional

A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation

NCT07487818
View directory record Official record
Conditions
Smoking Cessation
Interventions
Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches
Combination Product · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Not yet recruiting Not applicable Interventional

Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage

NCT07577739
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
Interventions
Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
Procedure · Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 9, 2026, 5:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Noninvasive VNS to Facilitate Excitability in Motor Cortex

NCT04130646
View directory record Official record
Conditions
Stroke, Stroke Sequelae, Motor Activity
Interventions
Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2025 · Synced Oct 9, 2026, 5:40 AM EDT
Completed Not applicable Interventional

VNS for Long-COVID-19

NCT05630040
View directory record Official record
Conditions
Post-COVID-19 Syndrome, Postural Tachycardia Syndrome, Dysautonomia
Interventions
Non-invasive vagus nerve stimulation, Sham Intervention
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 8, 2024 · Synced Oct 9, 2026, 5:40 AM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Neurostimulation After Lumbar Surgery

NCT06100172
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use, Lumbar Spine Injury
Interventions
Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN), Sham Control Device
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 9, 2026, 5:40 AM EDT
Not yet recruiting Phase 2 Interventional

nVNS, CBD, and SoC for Persistent Post-Traumatic Headache

NCT07624279
View directory record Official record
Conditions
Persistent Post Traumatic Headache
Interventions
Non-Invasive Vagus Nerve Stimulation, Cannabidiol, Standard of Care
Device · Drug
Lead sponsor
American Society of Pain and Neuroscience, Inc.
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
8
States / cities
Scottsdale, Arizona • Los Angeles, California • Washington D.C., District of Columbia + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 9, 2026, 5:40 AM EDT