Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:31 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 817–840 of 1,623 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: normal saline solution placebo Clear all

Conditions: Post-operative Cognitive Decline, Post-operative Delirium
Interventions: Aspart insulin, Normal saline, Intranasal mucosal atomizer device; Drug · Device
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 65 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: HIV Infections
Interventions: tocilizumab, Placebo; Drug
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Fractures, Closed, Wounds and Injuries
Interventions: cefazolin, Placebo; Drug
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Awake Fiberoptic Intubation, Difficult Airway
Interventions: Dexmedetomidine; Drug
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2034
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Primary Hyperoxaluria Type 1 (PH1)
Interventions: Placebo, Lumasiran; Drug
Lead sponsor: Alnylam Pharmaceuticals; Industry
Eligibility: 6 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 5
States / cities: San Diego, California • Jacksonville, Florida • Rochester, Minnesota + 2 more

Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Hypotension, Blood Pressure
Interventions: Dopamine, Hydrocortisone, Infusion Placebo, Syringe Placebo; Drug
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: Up to 24 Hours
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 17
States / cities: Birmingham, Alabama • Palo Alto, California • New Haven, Connecticut + 13 more

Conditions: Postoperative Delirium, Sleep, Anesthesia
Interventions: Dexmedetomidine, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 60 Years and older
Enrollment: 469 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain
Interventions: Placebo Comparator, Active Comparator; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 64 Years · Female only
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 2
States / cities: Chicago, Illinois

Conditions: Sialorrhea
Interventions: Atropine (0.01mg/kg), Glycopyrrolate (0.01mg/kg), Normal saline 0.9%; Drug
Lead sponsor: Craig J. Huang; Other
Eligibility: 6 Months to 18 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Bupivacaine, Pain, Postoperative
Interventions: Bupivacaine, Liposomal bupivacaine, Placebos; Drug
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: 18 Years and older · Female only
Enrollment: 132 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Fort Sam Houston, Texas

Conditions: Respiratory Syncytial Virus Infections
Interventions: GSK3888550A RSV Maternal vaccine formulation 1, GSK3888550A RSV Maternal vaccine formulation 2, GSK3888550A RSV Maternal vaccine formulation 3, Placebo (Normal Saline); Biological · Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 502 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: Lenexa, Kansas • Rochester, New York

Conditions: Ureteral Stent Placement, Kidney Stone
Interventions: Ketorolac Trometamol 30Mg/1mL Injection, Normal saline; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Type 1 Diabetes Mellitus
Interventions: mAb hOKT3gamma1(Ala-Ala), Teplizumab, Placebo Arm; Drug
Lead sponsor: Yale University; Other
Eligibility: 8 Years to 30 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 4
States / cities: San Francisco, California • Aurora, Colorado • New Haven, Connecticut + 1 more

Conditions: Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease, Ketamine Infusion, Pain Management, Vaso-Occlusive Crises
Interventions: Sub-dissociative Ketamine Infusion, Normal Saline Placebo Infusion; Drug
Lead sponsor: Mohsen Saidinejad; Other
Eligibility: 5 Years to 20 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Torrance, California

Conditions: Pain
Interventions: Bipivacaine 0.5% with epinephrine, Normal Saline; Drug
Lead sponsor: Souza, Amanda, M.D.; Individual
Eligibility: 21 Years to 65 Years · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Farmington Hills, Michigan

Conditions: Acromegaly, Growth Hormone Deficiency, Pituitary Disease
Interventions: Recombinant human growth hormone, Saline; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Healthy
Interventions: ketorolac, placebo, remifentanil, Capsaicin; Drug
Lead sponsor: Wake Forest University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Cardiovascular Disease
Interventions: Antioxidant cocktail, Biopsy, Placebo, NMD; 0.4mg sub-lingual nitroglycerin spray; Dietary Supplement · Other · Drug
Lead sponsor: Augusta University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 74 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2027
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: Arthritis Multiple Joint
Interventions: Botulinum Toxin Type A, Steroid - Triamcinolone Acetonide, Lidocaine; Drug
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Postoperative Depression
Interventions: Ketamine, Normal saline; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Sexual Behavior, Sexual Activity
Interventions: Platelet Rich Plasma, Saline; Other
Lead sponsor: Medstar Health Research Institute; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Squamous Cell Carcinoma in Situ
Interventions: STP705, Placebo Saline; Drug · Other
Lead sponsor: Sirnaomics; Industry
Eligibility: 18 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 7
States / cities: Scottsdale, Arizona • Aventura, Florida • West Palm Beach, Florida + 4 more

Conditions: Intracranial Embolism, Cerebral Thromboembolism, Carotid Stenosis
Interventions: ARC1779 Injection, Placebo (normal saline); Drug
Lead sponsor: Archemix Corp.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 2
States / cities: Hackensack, New Jersey • Houston, Texas

Conditions: Cardiac Arrest, Shock, Lactic Acidosis, Thiamin Deficiency
Interventions: Thiamine, placebo; Drug · Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

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Cardiac Surgery Neuroprotection Study in Elders

AIDS 347: IL-6 Blockade in Treated HIV Infection

Antibiotic Prophylaxis in Orthopaedic Traumatology

Comparison of Two Sedation Regimens for Awake Fiberoptic Intubation

A Study to Evaluate Lumasiran in Children and Adults With Primary Hyperoxaluria Type 1

Early Blood Pressure Management in Extremely Premature Infants

Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep

Use of Dexmedetomidine for Deep Sedation in Patients Undergoing Outpatient Hysteroscopic Surgery

Effectiveness of Atropine and Glycopyrrolate to Reduce Hyper Salivation With Ketamine Sedation

Wound Infiltration of Liposomal Bupivacaine v Plain Bupivacaine for Post-Op Pain Control in Elective Cesarean Delivery

A Study to Evaluate Different Dose Levels of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3888550A), Based on the Vaccine Safety and the Antibodies (Body Defences) Produced Following Vaccine Administration, When Given to Healthy Non-pregnant Women

NSAIDs Stent Study

Anti-CD3 mAb Treatment of Recent Onset Type 1 Diabetes

Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults

Bupivacaine Injections Into Uterosacral Ligaments During Robotic Assisted Total Hysterectomies

Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency

Effect of Spinal Ketorolac After Acute Opioid Exposure

Nitric Oxide Bioavailability and Early Life Stress (NO-Stress)

Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint

Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial

Vaginal Injection of Platelet Rich Plasma for Sexual Function

A Study to Evaluate Safety, Efficacy of Intralesional Injection of STP705 in Patients With isSCC

Effect of ARC1779 on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest