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ClinicalTrials.gov public records Last synced Nov 6, 2026, 6:11 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1201–1224 of 1,430 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: opiates Clear all

Conditions: Acute Back Pain
Interventions: Battlefield auricular acupressure, Sham; Procedure
Lead sponsor: Hackensack Meridian Health; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Hackensack, New Jersey

Conditions: Gastrointestinal Malignancy, Pain Control
Interventions: Erector Spinae Plane Block; Procedure
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 4
States / cities: Philadelphia, Pennsylvania

Conditions: Healthy Volunteers
Interventions: Reformulated OXY (oxycodone HCl), Original OxyContin® (OXY) (oxycodone HCl); Drug
Lead sponsor: Purdue Pharma LP; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 84 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Carpal Tunnel Syndrome, Dupuytren Contracture, Trigger Digit, Ganglion Cysts, De Quervain Disease
Interventions: Oxycodone Hcl 5Mg, Ibuprofen 400 mg, Acetaminophen 650 mg; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Pain, Hernia
Interventions: Ibuprofen, Opioid Medication, Placebo, Ibuprofen + Opioid medication; Drug
Lead sponsor: Mike O'Callaghan Military Hospital; Federal
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Nellis Air Force Base, Nevada

Conditions: Obesity
Interventions: Phentermine-Topiramate, Liraglutide, Naltrexone/bupropion, Phentermine; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 75 Years
Enrollment: 193 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Opioid-Related Disorders, Opiate Dependence
Interventions: Buprenorphine/naloxone sublingual tablets, Buprenorphine; Drug
Lead sponsor: Orexo AB; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 313 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 14
States / cities: Birmingham, Alabama • Haleyville, Alabama • National City, California + 11 more

Conditions: Pyromania
Interventions: Naltrexone, Placebo; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 16 Years to 75 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Drug Addiction, Stimulant Dependence, Opiate Dependence, Alcohol Dependence, Substance Abuse
Interventions: Community Reinforcement and Family Training, Treatment Entry Training, 12- step Al/Nar- Anon Facilitation; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use Disorder, Neonatal Abstinence Syndrome, Child Development, Child Abuse, Child Neglect
Interventions: RESPECT-Plus; Behavioral
Lead sponsor: Boston Medical Center; Other
Eligibility: Up to 21 Days
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Surgery
Interventions: Hydromorphone Hydrochloride; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 601 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 2
States / cities: Jacksonville, Florida • Rochester, Minnesota

Conditions: Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain
Interventions: Dexamethasone, Acetaminophen, Lyrica, Celebrex, Meloxicam, Oxycodone, Ropivacaine; Drug
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Opioid-use Disorder
Interventions: Buprenorphine / Naloxone Oral Product, injectable naltrexone, Pharmacy maintenance addiction care; Drug · Other
Lead sponsor: Lifespan; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Autism Spectrum Disorder
Interventions: 50 mg naltrexone; Drug
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 12 Years to 80 Years
Enrollment: 1 participant
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Neonatal Opiate Withdrawal Syndrome
Interventions: Finnegan Neonatal Abstinence Scoring Tool, Eat, Sleep, Console (ESC) care tool; Other
Lead sponsor: Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW) Program; Network
Eligibility: Up to 3 Days
Enrollment: 1,305 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 26
States / cities: Newark, Delaware • Tampa, Florida • Honolulu, Hawaii + 21 more

Conditions: Pain
Interventions: Mindfulness, Naloxone, Saline, Meditation; Behavioral · Drug · Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 65 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: La Jolla, California • San Diego, California

Conditions: Chronic Pain
Interventions: Morphine, Guanfacine 1mg, Guanfacine 2mg, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Atopic Dermatitis, Pruritus, Pruritus Chronic, Dermatitis
Interventions: Naltrexone, Placebo; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Opioid Use, Opioid Dependence, Opioid-use Disorder, Narcotic Use, Back Pain, Back Injuries, Chronic Pain, Chronic Low-back Pain, Pain, Chronic, Pain;Back Low;Chronic, Pain, Back
Interventions: Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Substance Use Disorders
Interventions: ThermoNeuroModulation TNM Device; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Fibromyalgia
Interventions: Low Dose Naltrexone; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Nephrolithiasis
Interventions: 5mg Oxycodone, Q6 PRN, 10mg Ketorolac, Q6 PRN; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Gastric Motility Disorder
Interventions: Methylnaltrexone only, Codeine only, Methylnaltrexone + codeine, Placebo + placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Obesity, Smoking Cessation, Bariatric Surgery Patients
Interventions: Naltrexone Hydrochloride, Bupropion HCl Extended Release, Cognitive-Behavioral Therapy; Drug · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

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Battlefield Acupressure for Acute Back Pain Management in the Emergency Department

The Erector Spinae Plane Block For Gastrointestinal Malignancy Pain Treatment (EGIPT)

A Study to Determine the Fasting Bioequivalence of Reformulated OXY Tablets and Original OxyContin® (OXY) Tablets

Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery

Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy

Individualized Obesity Pharmacotherapy

Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence

Naltrexone in the Treatment of Pyromania

CRAFT Behavior Therapy: Treatment Entry Component

RESPECT-PLUS: Services for Infants With Prenatal Opiate Exposure

Outcomes of Intrathecal Analgesia in Colorectal Surgery

Pre vs Post Block in Total Knee Arthroplasty (TKA)

Medication Maintenance Therapy in Community Pharmacy Settings

Participant(s) With Autism and High Pain Tolerance Treated With High Dose Naltrexone

Eating, Sleeping, Consoling for Neonatal Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach

Chronic Low Back Pain and Meditation

Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance

Treatment of Chronic Itch in Atopic Dermatitis With Opioid Antagonist Naltrexone

Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

Investigating the Efficacy of Caloric Vestibular Stimulation in the Treatment of Substance Use Disorders

Low Dose Naltrexone (LDN) Immune Monitoring

Narcotic-Free Percutaneous Nephrolithotomy

Effect of Methylnaltrexone on GI Transit in Healthy Volunteers

Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients