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ClinicalTrials.gov public records Last synced Nov 7, 2026, 2:25 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1225–1248 of 1,430 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: opiates Clear all

Conditions: Rib Fractures, Rib Fracture Multiple
Interventions: Bupivacaine, Fentanyl, morphine, hydromorphone, hydrocodone, acetaminophen, ketorolac, gabapentin, ketamine, ibuprofen; Drug
Lead sponsor: Andrew A Herring; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Oakland, California

Conditions: Opioid-Related Disorders, Pain, Acute, Pain, Postoperative
Interventions: Norco 5Mg-325Mg Tablet, GRT7014 - Abuse Deterrent Tablet; Drug
Lead sponsor: Grünenthal GmbH; Industry
Eligibility: 18 Years to 55 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Lenexa, Kansas

Conditions: Low Back Pain
Interventions: Oxycodone or morphine sulfate immediate release (MSIR), Placebo Treatment; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 25 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Conditions Requiring Colorectal Surgery
Interventions: EXPAREL, Intrathecal hydromorphone; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 209 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Post-surgical Pain
Interventions: CA-008, Placebo, Ketorolac, Acetaminophen, Oxycodone, Bupivacaine Hydrochloride; Drug
Lead sponsor: Concentric Analgesics; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 147 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 3
States / cities: Pasadena, California • Pasadena, Maryland • Houston, Texas

Conditions: Human Immunodeficiency Virus
Interventions: Intervention Arm (computer-based CARE+ Corrections tool), Educational video on opiate overdose prevention; Device · Other
Lead sponsor: George Washington University; Other
Eligibility: 18 Years and older
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Pain, Virtual Reality, Placebo
Interventions: Naloxone, Saline; Drug · Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 65 Years
Enrollment: 211 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
Interventions: buprenorphine; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 159 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Methamphetamine Use Disorder
Interventions: naltrexone plus bupropion; Drug
Lead sponsor: Walter Ling; Other
Eligibility: 18 Years to 65 Years
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 3
States / cities: Los Angeles, California • Honolulu, Hawaii • Dallas, Texas

Conditions: Alcoholism
Interventions: naltrexone (Revia), broad spectrum treatment, motivational enhancement therapy; Drug · Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2006
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Post-operative Pain, Post-partum Pain, Cesarean Section Complications
Interventions: Ketorolac; Drug
Lead sponsor: Tufts Medical Center; Other
Eligibility: 16 Years and older · Female only
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid-Related Disorders, Substance-Related Disorders
Interventions: Buprenorphine/naloxone; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 23 Years to 59 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 1997
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Pain
Interventions: Codeine; Drug
Lead sponsor: Roxane Laboratories; Industry
Eligibility: 2 Years to 17 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Tibial Plateau Fractures
Interventions: Saline injection, Multimodal injections; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 79 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2028
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Cancer
Interventions: Morphine, Oxcarbazepine; Drug
Lead sponsor: Costantine Albany; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 2
States / cities: Indianapolis, Indiana

Conditions: Pain
Interventions: Morphine Sulfate; Drug
Lead sponsor: Roxane Laboratories; Industry
Eligibility: 2 Years to 17 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 11
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Stanford, California + 8 more

Conditions: Pain, Respiratory Depression
Interventions: Hydromorphone, Usual care group; Drug
Lead sponsor: Albert Einstein Healthcare Network; Other
Eligibility: 60 Years to 90 Years
Enrollment: 116 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Heroin Dependence, Opioid-Related Disorders
Interventions: Not listed
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Amputation, Chronic Pain
Interventions: morphine and mexiletine; Drug
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2003
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Post Operative Pain
Interventions: Oxycodone, Tramadol and Oxycodone; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 560 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Opioid Overdose
Interventions: Naloxone, Marijuana; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 55 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Rotator Cuff Tear, Postoperative Pain
Interventions: Liposomal bupivacaine (LB); Drug
Lead sponsor: Orthopaedic & Neurosurgery Specialists; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Greenwich, Connecticut

Conditions: Idiopathic Pulmonary Fibrosis
Interventions: NAL ER, Placebo; Drug
Lead sponsor: Trevi Therapeutics; Industry
Eligibility: 40 Years and older
Enrollment: 201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 4
States / cities: Wilmington, Delaware • North Miami Beach, Florida • Charlotte, North Carolina + 1 more

Conditions: Postoperative Pain
Interventions: Q8003 (morphine sulfate and oxycodone hydrochloride), Morphine sulfate, Oxycodone HCl; Drug
Lead sponsor: QRxPharma Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 375 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 4
States / cities: Anaheim, California • Owings Mills, Maryland • Pasadena, Maryland + 1 more

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US-guided SAPB for Rib Fractures in the ED

A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults

Sensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain

Exparel Transversus Abdominis Plane Block vs Intrathecal Analgesia In Colorectal Surgery

Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients

CARE Corrections: Technology for Jail HIV/HCV Testing, Linkage, and Care (TLC)

Neural Correlates of Hypoalgesia Driven by Observation

HIV, Buprenorphine, and the Criminal Justice System (STRIDE2)

Accelerated Development of Additive Pharmacotherapy Treatment for Methamphetamine Use Disorder

Post-Treatment Effects of Naltrexone

Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial

Buprenorphine/Naloxone for Opiate-Dependence Treatment - 1

A Study of Oral Codeine Sulfate in Pediatric Patients With Post-procedural Pain

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures

Oxcarbazepine Plus Morphine in Patients With Refractory Cancer Pain

Safety and Pharmacokinetic Study of Oral Morphine Sulfate in Pediatric Subjects

Study of Respiratory Depression When Using a Hydromorphone Pain Protocol

Effects of Stress and Other Factors on Opiate Drug Choice.

Efficacy of Opioids and Mexiletine for the Treatment of Postamputation Pain

Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty

Vaped Marijuana to Attenuate Naloxone-Precipitated Withdrawal

Liposomal Bupivacaine for Pain Control After Rotator Cuff Repair

Idiopathic Pulmonary Fibrosis (IPF)-Related Chronic Cough Reduction With Nalbuphine (NAL) Extended-Release (ER) Tablets

Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients