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ClinicalTrials.gov public records Last synced Sep 26, 2026, 1:48 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: optical measurements Clear all
Withdrawn No phase listed Observational

Non-Invasive Oral Biofilm Characterization

NCT02178046
View directory record Official record
Conditions
Gingivitis
Interventions
optical measurements
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 26, 2026, 1:48 AM EDT
Completed No phase listed Observational

Refractive and Visual Outcomes With the ARGOS Biometer In Eyes With a History of Refractive Surgery: ARGOS Study

NCT07129980
View directory record Official record
Conditions
Cataract
Interventions
ARGOS Biometer
Device
Lead sponsor
Vance Thompson Vision
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Aug 23, 2025 · Synced Sep 26, 2026, 1:48 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Direct Comparison of SVOne Obtained Refraction to Subjective Manifest Refraction

NCT03222661
View directory record Official record
Conditions
Refractive Errors
Interventions
Refraction
Diagnostic Test
Lead sponsor
Smart Vision Labs
Industry
Eligibility
12 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 18, 2017 · Synced Sep 26, 2026, 1:48 AM EDT
Recruiting Not applicable Interventional

Development of Optical Biometer

NCT07325162
View directory record Official record
Conditions
Cataract and IOL Surgery
Interventions
New Investigational Optical Biometer (Device), Comparator Device A (Cassini Ambient), omparator Device B (Argos)
Device
Lead sponsor
Cassini Technologies
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Hilton Head Island, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 26, 2026, 1:48 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Skin Imaging to Inform Laser Treatments

NCT04336163
View directory record Official record
Conditions
Port-Wine Stain, Rosacea, Telangiectasia, Angioma
Interventions
Optical Coherence Tomography
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
4 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Sep 26, 2026, 1:48 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Measuring How Quickly the Eye Focuses After Sustained Viewing of Close-up Images and Videos

NCT07679048
View directory record Official record
Conditions
Distance Viewing, Prolonged Near Viewing
Interventions
Near viewing first, Distant viewing first
Other
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
18 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 26, 2026, 1:48 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease

NCT00793806
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Diffuse Optical Spectroscopy
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
3
States / cities
Irvine, California • Orange, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Sep 26, 2026, 1:48 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Newborn Screening for Critical Congenital Heart Disease

NCT01765205
View directory record Official record
Conditions
Congenital Cardiovascular Malformation
Interventions
Pulse Oximetry using the INVOS (In Vivo Optical Spectroscopy) Cerebral/Somatic Oximeter
Device
Lead sponsor
University of Florida
Other
Eligibility
12 Hours to 2 Weeks
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 13, 2014 · Synced Sep 26, 2026, 1:48 AM EDT
Completed Not applicable Interventional Results available

Spectacles for Patients With Down Syndrome

NCT03367793
View directory record Official record
Conditions
Vision, Low
Interventions
Spectacles - Clinically Derived, Spectacles - Metric Technique #1 Derived, Spectacles - Metric Technique #2 Derived
Device
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 24, 2021 · Synced Sep 26, 2026, 1:48 AM EDT
Completed No phase listed Observational

Laser Spectroscopy of Breast Tissue Through a Needle Device

NCT00918788
View directory record Official record
Conditions
Breast Cancer
Interventions
biologic sample preservation procedure, immunohistochemistry staining method, light microscopy, medical chart review, histopathologic examination, needle biopsy, spectroscopy
Other · Procedure
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 21, 2013 · Synced Sep 26, 2026, 1:48 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Transdermal Optical Imaging (TOI) as a Non-invasive Measure to Detect Changes in Hydration Status in Healthy Adults and Athletes

NCT06212518
View directory record Official record
Conditions
Dehydration
Interventions
GENPOP ad libitum fluid intake, GENPOP fluid restriction, ATHLETE ad libitum fluid intake, ATHLETE restricted fluid intake
Other
Lead sponsor
PepsiCo Global R&D
Industry
Eligibility
14 Years to 65 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
4
States / cities
Bradenton, Florida • Chicago, Illinois • Valhalla, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Sep 26, 2026, 1:48 AM EDT
Recruiting No phase listed Observational

Continuous Jugular Venous Oxygen Saturation (SjO2) Measurement After Cardiac Arrest

NCT06511999
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Continuous SjO2 monitoring with a PediaSat Oximetry Catheter, Intermittent SjO2 monitoring with a PediaSat Oximetry Catheter
Device · Diagnostic Test
Lead sponsor
Byron Drumheller
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 26, 2026, 1:48 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Neonatal Pulse Oximetry Disparities Due to Skin Pigmentation

NCT06063148
View directory record Official record
Conditions
Skin Pigment, Pulse Oximetry
Interventions
Enrolled Participant
Device
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 10 Days
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Sacramento, California • Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 26, 2026, 1:48 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Longitudinal Spatial Frequency Domain Imaging Study

NCT05672992
View directory record Official record
Conditions
Systemic Scleroderma
Interventions
Spatial-frequency domain imaging (SFDI)
Other
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 26, 2026, 1:48 AM EDT
Completed Not applicable Interventional Results available

OCT Pilot in Esophagus

NCT03434834
View directory record Official record
Conditions
Barrett Esophagus
Interventions
optical coherence tomography
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2021 · Synced Sep 26, 2026, 1:48 AM EDT
Terminated Phase 2 Interventional Results available

Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma

NCT01471054
View directory record Official record
Conditions
Macular Edema, Cystoid Macular Edema, Uveal Melanoma, Radiation Maculopathy, Radiation Retinopathy
Interventions
Ozurdex, Bevacizumab
Drug
Lead sponsor
Arman Mashayekhi
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 2, 2019 · Synced Sep 26, 2026, 1:48 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours

NCT00875043
View directory record Official record
Conditions
Blindness
Interventions
Not listed
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Sep 26, 2026, 1:48 AM EDT
Completed Not applicable Interventional Results available

A Pilot Study of Optic Nerve Ultrasound Following Cardiopulmonary Bypass

NCT03757312
View directory record Official record
Conditions
Congenital Heart Disease, Congenital Heart Defect
Interventions
Ultrasound
Diagnostic Test
Lead sponsor
Marco Corridore
Other
Eligibility
Up to 18 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 12, 2021 · Synced Sep 26, 2026, 1:48 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Objectively Diagnose and Monitor Treatment of Light Sensitivity

NCT03694626
View directory record Official record
Conditions
Photophobia, Traumatic Brain Injury, Migraine
Interventions
Pupillography, Ocular Coherence Tomography (OCT), Wrist-watch sensor device, Videography, Electrophysiology
Device
Lead sponsor
Randy Kardon
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 7, 2026 · Synced Sep 26, 2026, 1:48 AM EDT
Not listed No phase listed Observational

OCT and Scaffold Embedding After NC Balloon

NCT03106961
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Bioresorbable vascular scaffolds, OCT, non-compliant ballooning
Device
Lead sponsor
St. Francis Hospital, New York
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Roslyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Sep 26, 2026, 1:48 AM EDT
Active, not recruiting No phase listed Observational

Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography

NCT04772911
View directory record Official record
Conditions
Vascular Stains
Interventions
Optical Coherence Tomography (OCT)
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
Not listed
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Irvine, California • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 26, 2026, 1:48 AM EDT
Not yet recruiting Phase 2 Interventional

Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial)

NCT07808333
View directory record Official record
Conditions
Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG)
Interventions
Nicotinamide, Standard Glaucoma Therapy
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
40 Years to 80 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 26, 2026, 1:48 AM EDT
Completed No phase listed Observational Results available

Randomized Trial Comparing Prediction Accuracy of Two Swept Source Optical Coherence Tomography Biometers

NCT05748275
View directory record Official record
Conditions
Cataract
Interventions
Argos, IOLMaster 700
Diagnostic Test
Lead sponsor
Multack Eye Care
Other
Eligibility
50 Years to 85 Years
Enrollment
80 participants
Timeline
2021
U.S. locations
1
States / cities
Frankfort, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 26, 2026, 1:48 AM EDT
Completed Not applicable Interventional Results available

Jointstrong Intervention for Juvenile Arthritis

NCT01166750
View directory record Official record
Conditions
Juvenile Arthritis
Interventions
CD-ROM, Wait-list Control Group
Behavioral
Lead sponsor
Michael Rapoff, Ph.D.
Other
Eligibility
8 Years to 12 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 30, 2013 · Synced Sep 26, 2026, 1:48 AM EDT