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ClinicalTrials.gov public records Last synced Oct 18, 2026, 4:00 AM EDT

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Showing 1–24 of 757 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: pain blocking Clear all
Completed Early Phase 1 Interventional

Basivertebral Nerve Block During Vertebral Augmentation: An Alternative Approach to Intraprocedural Pain Management

NCT04774029
View directory record Official record
Conditions
Vertebral Compression, Vertebra Compression Fracture, Vertebral Fracture
Interventions
Basivertebral nerve block, Lidocaine induced basivertebral nerve block
Procedure · Drug
Lead sponsor
Northwell Health
Other
Eligibility
50 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Port Jefferson, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2021 · Synced Oct 18, 2026, 4:00 AM EDT
Terminated Not applicable Interventional

Serratus Anterior Plane Block for Management of Post Thoracotomy Pain

NCT04258436
View directory record Official record
Conditions
Opioid Use, Post-thoracotomy Pain Syndrome, Local Anaesthetic Agent Overdose, Local Anesthetic Complication, Pain, Postoperative
Interventions
Serratus anterior block
Procedure
Lead sponsor
Indiana University
Other
Eligibility
38 Weeks to 12 Months
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 18, 2023 · Synced Oct 18, 2026, 4:00 AM EDT
Completed Phase 4 Interventional Results available

Pre vs Post Block in Total Knee Arthroplasty (TKA)

NCT05974501
View directory record Official record
Conditions
Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain
Interventions
Dexamethasone, Acetaminophen, Lyrica, Celebrex, Meloxicam, Oxycodone, Ropivacaine
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Oct 18, 2026, 4:00 AM EDT
Recruiting Phase 2 Interventional

Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery

NCT03541928
View directory record Official record
Conditions
High-risk Prostate Cancer, Prostate Cancer
Interventions
HSV-Tk, Valacyclovir, Bicalutamide, Leuprolide Acetate, Brachytherapy, External beam radiotherapy, Radical prostatectomy
Drug · Radiation · Procedure
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older · Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 6, 2021 · Synced Oct 18, 2026, 4:00 AM EDT
Completed Phase 4 Interventional Results available

Interscalene Block Versus Superior Trunk Block

NCT03272139
View directory record Official record
Conditions
Joint Disease, Pain, Pain, Acute, Pain, Chronic
Interventions
Bupivacaine, Ultrasound
Drug · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 18, 2026, 4:00 AM EDT
Completed Phase 4 Interventional Results available

Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?

NCT04124939
View directory record Official record
Conditions
Overactive Bladder
Interventions
OnabotulinumtoxinA 100 Units
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Greensboro, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2024 · Synced Oct 18, 2026, 4:00 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Comparison of Anesthetic Techniques on Total Hip Arthroplasty

NCT01359865
View directory record Official record
Conditions
Osteoarthritis
Interventions
Lumbar Plexus Block
Procedure
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 2, 2015 · Synced Oct 18, 2026, 4:00 AM EDT
Terminated Phase 4 Interventional Results available

Postoperative Pain Control Following Renal Transplant

NCT05044429
View directory record Official record
Conditions
Kidney Transplant; Complications, Pain, Postoperative
Interventions
Intravenous Lidocaine, Transversus abdominis plane (TAP) block, Quadratus Lumborum (QL) Block
Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 99 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 18, 2024 · Synced Oct 18, 2026, 4:00 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain

NCT04368364
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Intrathecal morphine sulfate (ITM), Bupivacaine hydrochloride, ropivacaine hydrochloride
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 16, 2022 · Synced Oct 18, 2026, 4:00 AM EDT
Completed Phase 4 Interventional Results available

Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain

NCT02024724
View directory record Official record
Conditions
Typical Facial Pain, Atypical Facial Pain
Interventions
Bupivacaine, Triamcinolone, Dexamethasone
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Oct 18, 2026, 4:00 AM EDT
Not listed Not applicable Interventional

Medial Versus Traditional Approach to US-guided TAP Blocks for Open Inguinal Hernia Repair

NCT01589796
View directory record Official record
Conditions
Abdominal Muscles/Ultrasonography, Adult, Ambulatory Surgical Procedures, Anesthetics, Local/Administration & Dosage, Ropivacaine/Administration & Dosage, Ropivacaine/Analogs & Derivatives, Hernia, Inguinal/Surgery, Humans, Nerve Block/Methods, Pain Measurement/Methods, Pain, Postoperative/Prevention & Control, Ultrasonography, Interventional
Interventions
TAP block
Procedure
Lead sponsor
Stamford Anesthesiology Services, PC
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
2
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 2, 2012 · Synced Oct 18, 2026, 4:00 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine in Rotator Cuff Repair

NCT03738696
View directory record Official record
Conditions
Rotator Cuff Injury
Interventions
Exparel, Ropivacaine
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Oct 18, 2026, 4:00 AM EDT
Not listed Not applicable Interventional

Peripheral Nerve Block Compared to Intra-articular Injection for TAA Post-operative Pain

NCT03674905
View directory record Official record
Conditions
Ankle Arthritis, Ankle Arthropathy
Interventions
Intra-articular injection, Peripheral nerve block
Procedure
Lead sponsor
Slocum Research & Education Foundation
Other
Eligibility
40 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Oct 18, 2026, 4:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sphenopalatine Ganglion Block to Treat Shoulder Pain During and/or After Cesarean

NCT02670057
View directory record Official record
Conditions
Ipsilateral Shoulder Pain
Interventions
Transnasal SPG block
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older · Female only
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 14, 2017 · Synced Oct 18, 2026, 4:00 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Liposomal Bupivacaine in Total Shoulder Arthroplasty

NCT02570022
View directory record Official record
Conditions
Pain
Interventions
Liposomal bupivacaine, Inter-scalene nerve block, Ropivacaine
Drug · Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Oct 18, 2026, 4:00 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Self-Administered Lidocaine Gel for Pain Management With First Trimester Surgical Abortion: A Randomized Controlled Trial

NCT02447029
View directory record Official record
Conditions
Pregnancy, Unwanted
Interventions
vaginal 2% Xylocaine, standard lidocaine paracervical block
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Oct 18, 2026, 4:00 AM EDT
Recruiting Not applicable Interventional

ESP Block in MIS Lumbar Spine Surgery

NCT05856539
View directory record Official record
Conditions
Patients With Spinal Stenosis Indicated for MIS TLIF
Interventions
Erector spinae plane (ESP) block
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Oct 18, 2026, 4:00 AM EDT
Withdrawn Not applicable Interventional

High Ankle Block Versus Regional Block for Acute Pain Control After Ankle Surgery

NCT03894098
View directory record Official record
Conditions
Ankle Surgery
Interventions
Nerve block
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 27, 2022 · Synced Oct 18, 2026, 4:00 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Study Comparing Regional Anesthetic Blocks and Periarticular Infiltration for the Management of Post-operative Pain After Direct Anterior Total Hip Arthroplasty

NCT02904993
View directory record Official record
Conditions
Degenerative Joint Disease
Interventions
L2 paravertebral block, periarticular injection group
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 16, 2016 · Synced Oct 18, 2026, 4:00 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Does a ThoracoLumbar Interfacial Plane (TLIP) Block With Liposomal Bupivacaine Provide TLIP Block in Spinal Surgery

NCT04865211
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Liposomal bupivacaine, Bupivacaine Injection, Placebo
Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 29, 2021 · Synced Oct 18, 2026, 4:00 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures

NCT03651804
View directory record Official record
Conditions
Vertebral Compression Fracture, Facet Joint Pain
Interventions
Radiofrequency ablation of the medial branch nerves, Non-steroidal anti-inflammatory drugs, Bisphosphonates, Acetaminophen, Physical therapy, Opioids
Procedure · Drug · Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 18, 2026, 4:00 AM EDT
Completed Phase 4 Interventional Results available

Serratus Anterior Plane Block in Patients Undergoing Mastectomy

NCT03154658
View directory record Official record
Conditions
Pain, Post-operative
Interventions
Ropivacaine 0.35%
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Oct 18, 2026, 4:00 AM EDT
Terminated Phase 4 Interventional

Pain Control After Minimally Invasive Coronary Artery Bypass Grafting

NCT01770236
View directory record Official record
Conditions
Postoperative Pain, Medication Side Effects, Narcotic Requirement
Interventions
IV acetaminophen
Drug
Lead sponsor
Gundersen Lutheran Medical Foundation
Other
Eligibility
18 Years to 90 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
La Crosse, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 21, 2016 · Synced Oct 18, 2026, 4:00 AM EDT
Not yet recruiting Not applicable Interventional

FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy

NCT07637370
View directory record Official record
Conditions
Pulmonary Dysfunction, Median Sternotomy Recovery, Postoperative Pain
Interventions
Intercostal Nerve Cryoablation
Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
40 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 18, 2026, 4:00 AM EDT