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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: phenylephrine infusion Clear all
Not listed Phase 1 Interventional Accepts healthy volunteers

Study Developed to Evaluate the Effect of ANG-3777 on QT/QTc Interval

NCT04898907
View directory record Official record
Conditions
Healthy Volunteer
Interventions
ANG-3777 (Therapeutic Dose), ANG-3777 (Supra-therapeutic Dose), Placebo, Moxifloxacin Hydrochloride
Drug
Lead sponsor
Angion Biomedica Corp
Industry
Eligibility
18 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 31, 2021 · Synced Sep 1, 2026, 10:18 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury

NCT07210411
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Tests of sympathetic inhibition, Tests of above level sympathetic activation, Testing of below level sympathetic activation, Epidural stimulation, Transcutaneous stimulation
Diagnostic Test · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Phase 4 Interventional Results available

No Drop Post-Op Cataract Surgery

NCT03864133
View directory record Official record
Conditions
Cataract
Interventions
Omidria
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
55 Years to 90 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Sep 1, 2026, 10:18 PM EDT
Not listed Phase 2 Interventional

Methylene Blue as a Third-line Vasopressor in Septic Shock

NCT04089072
View directory record Official record
Conditions
Septic Shock
Interventions
Methylene Blue, Phenylephrine
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 25, 2022 · Synced Sep 1, 2026, 10:18 PM EDT
Recruiting Phase 4 Interventional

The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery

NCT06802224
View directory record Official record
Conditions
Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery, Acute Kidney Injury (AKI), Myocardial Injury After Noncardiac Surgery (MINS), Vasopressor
Interventions
Norepinephrine, Phenylephrine
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
18,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
9
States / cities
San Francisco, California • College Park, Maryland • Ann Arbor, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Phase 4 Interventional Results available

Oxytocin And Uterotonic Agent Use For Cesarean Delivery

NCT01549223
View directory record Official record
Conditions
Uterine Atony, Hypotension
Interventions
Oxytocin Infusion, Oxytocin Bolus
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2017 · Synced Sep 1, 2026, 10:18 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Deciphering Preserved Autonomic Function After Spinal Cord Injury

NCT04493372
View directory record Official record
Conditions
Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia, Orthostatic Hypotension
Interventions
Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Not applicable Interventional

The Development of Tolerance to α1-Adrenoceptor Blockade With Chronic Carvedilol Treatment

NCT00585091
View directory record Official record
Conditions
Heart Failure
Interventions
phenylephrine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 12, 2012 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Phenylephrine and Pulse Pressure Variability

NCT05011357
View directory record Official record
Conditions
Intraoperative Hypotension
Interventions
Phenylephrine, Saline Control
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 45 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Single-centre, Randomised, Double-blind, Placebo-controlled, Four Way Crossover Phase I Study to Investigate the Effect on QT/QTc Interval of Ceftazidime NXL104 or Ceftaroline Fosamil NXL104, Compared With Placebo, Using Moxifloxacin (Avelox®) as a Positive Control, in Healthy Male Volunteers

NCT01290900
View directory record Official record
Conditions
Healthy Male Volunteers
Interventions
NXL104, Ceftaroline, Placebo Infusion, Ceftazidime, Moxifloxacin
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 45 Years · Male only
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes

NCT04858178
View directory record Official record
Conditions
Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia, Orthostatic; Hypotension, Neurogenic
Interventions
Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia, Transcutaneous spinal cord stimulation
Diagnostic Test · Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Sep 1, 2026, 10:18 PM EDT
Withdrawn Not applicable Interventional

Phenylephrine Dose and Mode of Administration for Spinal Anesthesia Induced Hypotension

NCT02101047
View directory record Official record
Conditions
Complications; Cesarean Section, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Interventions
Phenylephrine
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2017 · Synced Sep 1, 2026, 10:18 PM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training

NCT03972683
View directory record Official record
Conditions
Vasoconstriction, Vasodilation
Interventions
Handgrip Exercise Training, Acetylcholine, Adenosine Triphosphate, Atropine, Phenylephrine, Sodium Nitroprusside
Other · Drug
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 1, 2021 · Synced Sep 1, 2026, 10:18 PM EDT
Recruiting Not applicable Interventional

Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

NCT07210437
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Tests of sympathetic inhibition, Tests of above level sympathetic activation, Testing of below level sympathetic activation
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 1, 2026, 10:18 PM EDT
Recruiting Not applicable Interventional

The GUARDIAN Trial

NCT04884802
View directory record Official record
Conditions
Blood Pressure
Interventions
Tight blood pressure management, Routine blood pressure management
Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
45 Years and older
Enrollment
6,254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
6
States / cities
Omaha, Nebraska • Wake Forest, North Carolina • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 1, 2026, 10:18 PM EDT
Terminated Phase 1 Interventional

Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension

NCT02245230
View directory record Official record
Conditions
Hypertension, Hypertension, Essential
Interventions
Angiotensin (1-7), Trimethaphan, Phenylephrine
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Variability in Adrenergic Response

NCT00838695
View directory record Official record
Conditions
Vascular Reaction to Medications
Interventions
Phenylephrine
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 40 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 25, 2018 · Synced Sep 1, 2026, 10:18 PM EDT
Enrolling by invitation Phase 4 Interventional

The GUARDIAN Trial - Vasopressor Sub-Study

NCT04934748
View directory record Official record
Conditions
Blood Pressure
Interventions
Routine Blood Pressure Management, Tight Blood Pressure Management, Phenylephrine, Norepinephrine
Procedure · Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
45 Years and older
Enrollment
6,254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
4
States / cities
Omaha, Nebraska • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Not applicable Interventional

Pilot Study of Real-Time Blood Pressure Decision Support During Cesarean Delivery Under Spinal Anesthesia

NCT07534774
View directory record Official record
Conditions
Spinal Hypotension
Interventions
ARX Decision-Support Display
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hyporeactivity and Gulf War Illness

NCT00100412
View directory record Official record
Conditions
Gulf War Syndrome, Chronic Fatigue Syndrome, Post-Traumatic Stress Disorder
Interventions
Graded dobutamine infusions, Graded phenylephrine injections, Psychosocial challenge involving socioevaluative public speaking
Drug · Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2002
U.S. locations
1
States / cities
East Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery

NCT02354833
View directory record Official record
Conditions
Effects of; Anesthesia, in Labor and Delivery
Interventions
Phenylephrine, Norepinephrine
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jan 3, 2017 · Synced Sep 1, 2026, 10:18 PM EDT
Recruiting Phase 4 Interventional

Vasoactive Drugs in Intensive Care Unit

NCT02118467
View directory record Official record
Conditions
Shock
Interventions
Norepinephrine, Epinephrine, Phenylephrine, Vasopressin
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
836 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 1, 2026, 10:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neonatal Acid-Base Status After C Section With Maternal Tilt vs. Supine

NCT02243423
View directory record Official record
Conditions
Aortocaval Compression, Fetal Acidosis
Interventions
SUPINE, TILT
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Sep 1, 2026, 10:18 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Topical Phenylephrine Solution in Preventing Oral Mucosa in Bone Marrow Transplant Patients Receiving Cyclophosphamide and Total Body Radiation Therapy

NCT02434146
View directory record Official record
Conditions
Neoplasm, Oral Mucosa, Transplant-Related Disorder
Interventions
Topical Phenylephrine Solution
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 8, 2019 · Synced Sep 1, 2026, 10:18 PM EDT