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ClinicalTrials.gov public records Last synced Oct 16, 2026, 11:46 PM EDT

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Showing 2329–2352 of 4,225 matching trials from the local directory fallback.

Filters: Intervention: placebo Clear all

Conditions: Idiopathic Pulmonary Fibrosis
Interventions: Matching Placebo, Metformin; Drug
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 40 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 15
States / cities: Tucson, Arizona • Aurora, Colorado • Washington D.C., District of Columbia + 11 more

Conditions: Chronic Low Back Pain
Interventions: DHEA, Placebo, Pregnenolone; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Major Depressive Disorder
Interventions: BMS-986511, Placebo; Drug
Lead sponsor: Bristol-Myers Squibb; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 21
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Rogers, Arkansas + 18 more

Conditions: Fatigue
Interventions: Active Health Performance Product, Placebo Health Performance Control; Dietary Supplement
Lead sponsor: Radicle Science; Industry
Eligibility: 35 Years to 60 Years
Enrollment: 650 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Del Mar, California

Conditions: Healthy Elder People
Interventions: Feru-guard, Placebo; Dietary Supplement · Other
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 65 Years to 89 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Cytomegalovirus (CMV), HIV (Human Immunodeficiency Virus)
Interventions: Placebo, VIR-1388; Biological
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Birmingham, Alabama • Boston, Massachusetts

Conditions: Plantar Fasciitis
Interventions: Matched Placebos, transdermal CBD cream (Tolcylen®, Marlinz Pharma); Drug
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 85 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Circadian Rhythm, Sleep
Interventions: Dexmedetomidine sublingual film, Placebo Sublingual Film; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 65 Years and older
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Alzheimer Disease Related Dementia
Interventions: Placebo, Probiotic Fermented Milk (PFM) Drink; Dietary Supplement
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Blood Pressure, Endothelial Dysfunction
Interventions: Empagliflozin (EMPA), Placebo; Drug · Other
Lead sponsor: Kanokwan Bunsawat; Other
Eligibility: 45 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Prostate Cancer
Interventions: Normal Saline Placebo, OnabotulinumtoxinA (BOTOX®); Other · Drug
Lead sponsor: The Methodist Hospital Research Institute; Other
Eligibility: 45 Years to 80 Years · Male only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Insomnia, Malignant Solid Neoplasm
Interventions: Biospecimen Collection, Placebo Administration, Single Agent Therapy; Procedure · Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 25 Years and older
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Alzheimer s Disease
Interventions: Placebo, Terazosin (Hytrin); Other · Drug
Lead sponsor: Qiang Zhang; Other
Eligibility: 50 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2032
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Healthy Adult, Intraocular Pressure (IOP)
Interventions: Eplerenone, Microcrystalline Cellulose NF (placebo); Drug
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 50 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Alzheimer's Disease
Interventions: Emtricitabine and tenofovir disoproxil fumarate combination, Placebo; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 55 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Endometriosis, Endometriosis-related Pain
Interventions: Placebo, Rimegepant 75 MG; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Smoking ( Cigarette)
Interventions: Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), Sugar syrup (Placebo), sucralose; Drug · Dietary Supplement
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 59 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Kava, Mobility Impairment, Old Adults, Physical Activity and Stress, Physical Impairment, Sedentary Lifestyle in Patients Over 70, Sleep Quality
Interventions: AB-free kava, Placebo; Drug · Other
Lead sponsor: University of Florida; Other
Eligibility: 70 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Gainesville, Florida

Conditions: Asthma
Interventions: Ginger Extract, Placebo; Drug
Lead sponsor: Emily DiMango, MD; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Muscle Loss, Obesity, Older Adults, Sarcopenia, Type 2 Diabetes Mellitus (T2DM)
Interventions: Calcium-HMB Plus Vitamin D3, Matching placebo; Dietary Supplement · Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 65 Years to 85 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Hypothyroidism
Interventions: Levothyroxine Pill, Placebo; Drug
Lead sponsor: Spyridoula Maraka; Other
Eligibility: 65 Years and older
Enrollment: 138 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 3
States / cities: Little Rock, Arkansas • Gainesville, Florida • Rochester, Minnesota

Conditions: Cannabis Use, PTSD, Post Traumatic Stress Disorder, Suicide
Interventions: Cannabidiol (CBD) only, Delta-9-tetrahydrocannabinol (THC) only, Placebo only, THC:CBD 1:1; Drug
Lead sponsor: Leslie Lundahl; Other
Eligibility: 18 Years to 60 Years
Enrollment: 280 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Interventions: Placebo, Pregnenolone; Drug
Lead sponsor: Sherwood Brown, MD, PhD; Other
Eligibility: 21 Years to 55 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 2
States / cities: Dallas, Texas • Richardson, Texas

Conditions: Depression - Major Depressive Disorder, Irritability
Interventions: Kurvelo, Placebo COC; Drug
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 12 Years to 16 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Chapel Hill, North Carolina

Search by objective public record fields.

Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis

Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial

A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder

Radicle PerformanceTM VKN: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes

Feru-guard and General Antioxidant Capacity in Older People

A Clinical Study to Evaluate the Safety and Immunogenicity of a Higher Dose of the Study Vaccine, VIR-1388, in HCMV-seropositive Adult Participants Without HIV

A Double-Blinded Study on Rapid and Sustained Pain Relief Topical Cannabidiol for Plantar Fasciitis

Dexmedetomidine Trial for Effects on Rhythms, Sleep Architecture, and Biomarker Dynamics in Older Adults

Probiotic Milk Drink for Gut and Brain Health in Older Adults and Caregivers

Neurovascular Effects of Empagliflozin

Neoadjuvant Intraprostatic OnabotulinumtoxinA Before Radical Prostatectomy for High-Risk Localized Prostate Cancer

THC Versus THC/CBD Versus Placebo to Improve Sleep Quality for Patients With Solid Organ Cancer and Insomnia

Terazosin And Metabolic Engagement in Alzheimer's Disease

Eplerenone and IOP in Healthy Adults

Repurposing a Combination Antiretroviral Drug Therapy to Target Retrotransposons and Treat Early Alzheimer's Disease

Rimegepant For Endometriosis Pain

Impact of Sweeteners on the Addictive Threshold of Nicotine

Kava Aging and Mobility Study

Ginger's Therapeutic Potential in Asthma

HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide

Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism

Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery

Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder

Teen Vulnerability to Irritability: Brain and Estrogen Changes