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Conditions: Preterm Birth, Child Development
Interventions: Docosahexaenoic Acid + Arachidonic Acid (DHA+AA), Placebo; Drug · Dietary Supplement
Lead sponsor: Sarah Keim; Other
Eligibility: 8 Years to 10 Years
Enrollment: 377 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: COVID-19, Coronavirus Infection, SARS CoV 2 Infection
Interventions: Placebo Comparator: Sterile Water, 27% Ethanol plus essential oils, 0.075% Cetylpyridinium Chloride; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 65 Years
Enrollment: 230 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Claustrophobia, Obsessive-Compulsive Disorder, Arachnophobia
Interventions: Experimental Scent, Control Scent, No-Scent Control, In-Vivo Exposure; Other · Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 65 Years
Enrollment: 158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Infant Development
Interventions: Docosahexaenoic acid (DHA) and arachidonic acid (ARA), Corn oil placebo; Dietary Supplement
Lead sponsor: Retina Foundation of the Southwest; Other
Eligibility: 351 Days to 379 Days
Enrollment: 116 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Schizophrenia, Fatty Acid Deficiency
Interventions: Omega-3 Fatty Acids, Olive oil placebo, EPA fish oil concentrate; DHA fish oil concentrate, Placebo; Dietary Supplement · Other · Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 8 Years to 25 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Spinal Cord Injuries, Polytrauma, Burns
Interventions: placebo; Other
Lead sponsor: Spaulding Rehabilitation Hospital; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Charlestown, Massachusetts

Conditions: Osteoarthritis, Knee
Interventions: Cannabidiol (CBD) Extract, Placebo; Drug
Lead sponsor: University of Florida; Other
Eligibility: 40 Years to 75 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Colposcopy
Interventions: Essential Lavender Oil, Lavender Scent; Other
Lead sponsor: Mike O'Callaghan Military Hospital; Federal
Eligibility: 18 Years and older · Female only
Enrollment: 262 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Dry Eye Syndrome
Interventions: Omega-3 fatty acid supplement, Placebo; Dietary Supplement
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 90 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Immune System
Interventions: Essential oil blend, Placebo; Other
Lead sponsor: Nutraceuticals Research Institute; Other
Eligibility: 20 Years to 65 Years · Female only
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Franklin, Tennessee

Conditions: Breast Cancer, Peripheral Neuropathies
Interventions: EOI, Placebo; Other
Lead sponsor: Augusta University; Other
Eligibility: 21 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: Cancer
Interventions: Ginger aromatherapy, Orange aromatherapy, Lavender aromatherapy, Jojoba aromatherapy; Other
Lead sponsor: University of Rochester; Other
Eligibility: 8 Years and older
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 2
States / cities: Buffalo, New York • Rochester, New York

Conditions: Prostate Cancer
Interventions: Mikei Red Reishi Essence EX, Placebo; Dietary Supplement
Lead sponsor: Nikkei (Canada) Marketing Limited; Industry
Eligibility: 50 Years to 85 Years · Male only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Total Knee Replacement, Post-operative Nausea and Vomiting, Opioid Use, Anxiety, Depression, Post Operative Pain
Interventions: Elequil Lavender-peppermint Aromatabs, Elequil Almond-Oil Aromatabs; Other
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Acute Leukemia, Anorexia, Anxiety, Depression, Dyspnea, Insomnia, Nausea, Pain
Interventions: Aromatherapy and Essential Oils, Placebo, Questionnaire Administration; Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: Not listed
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Healthy
Interventions: Placebo, Cognitive Support System; Other
Lead sponsor: dōTERRA International; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Pleasant Grove, Utah

Conditions: Healthy
Interventions: Supplement system + copaiba softgels, Supplement system + placebo softgels; Dietary Supplement
Lead sponsor: dōTERRA International; Industry
Eligibility: 30 Years to 55 Years
Enrollment: 97 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Pleasant Grove, Utah

Conditions: Psychological Stress
Interventions: Essential Oil Inhalation, Placebo Aroma Stick; Other
Lead sponsor: dōTERRA International; Industry
Eligibility: 18 Years to 45 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Pleasant Grove, Utah

Conditions: Epidermolysis Bullosa
Interventions: SD-101-6.0 cream, Placebo (SD-101-0.0) cream; Drug
Lead sponsor: Scioderm, Inc.; Industry
Eligibility: 1 Month and older
Enrollment: 169 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 21
States / cities: Phoenix, Arizona • Redwood City, California • Aurora, Colorado + 17 more

Conditions: Eye Health, Vision, Cognitive Function
Interventions: VisionPure Dietary Supplement, Placebo; Dietary Supplement
Lead sponsor: Applied Science & Performance Institute; Industry
Eligibility: 18 Years to 40 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 3
States / cities: Lutz, Florida • Tampa, Florida

Conditions: Covid19, Coronavirus Infection, SARS-CoV-2 Infection
Interventions: 0.9% w/v NaCL Saline, 1.5% w/v Hydrogen Peroxide, 0.12% Chlorohexidine Gluconate, 27% Ethanol plus essential oils, 0.5% w/v Povidone-iodide, 0.075% Cetylpyridinium Chloride; Other · Drug
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 65 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Stage 0 Nasopharyngeal Carcinoma, Stage 0 Paranasal Sinus Cancer, Stage I Nasopharyngeal Carcinoma, Stage I Paranasal Sinus Cancer, Stage II Nasopharyngeal Carcinoma, Stage II Paranasal Sinus Cancer, Stage IIA Nasopharyngeal Carcinoma, Stage IIB Nasopharyngeal Carcinoma, Stage III Nasopharyngeal Carcinoma, Stage III Paranasal Sinus Cancer, Stage IV Nasopharyngeal Carcinoma, Stage IV Paranasal Sinus Cancer, Stage IVA Nasopharyngeal Carcinoma, Stage IVA Paranasal Sinus Cancer, Stage IVB Nasopharyngeal Carcinoma, Stage IVB Paranasal Sinus Cancer, Stage IVC Nasopharyngeal Carcinoma, Stage IVC Paranasal Sinus Cancer
Interventions: Physiologic Testing, Quality-of-Life Assessment, Sham Intervention, Therapeutic Procedure, rose essential oil, lemon essential oil, clove essential oil, eucalyptus essential oil, canola oil placebo; Other · Procedure
Lead sponsor: Stanford University; Other
Eligibility: 19 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Surgical Abortion, Patient Satisfaction, Anesthesia, Pain
Interventions: Placebo oil, Lavender oil.; Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 144 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Anosmia, Skull Base Neoplasms
Interventions: Olfactory training, Placebo training; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

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Omega Tots Long Term Follow-up

Efficacy of Oral Rinses for Inactivation of COVID-19 (MOR2)

Efficacy of Targeted Memory Reactivation for Enhancing Exposure Therapy

Effect of Long-Chain Polyunsaturated Fatty Acid Supplementation on Toddler Cognition

Omega-3 Fatty Acid Deficiency Replacement in Early Schizophrenia

Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation

CBD for Knee Osteoarthritis

Aromatherapy to Reduce Pain and Anxiety During Cervical Colposcopy

A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome

Aromatherapy for Upper Respiratory Health

Chemotherapy-Induced Peripheral Neuropathy-Essential Oil Intervention

Aromatherapy for Integrated Cancer Care

Investigating the Effects of Mikei® Red Reishi Essence EX on the Immune System of Prostate Cancer Patients and Patients With Non-cancerous Conditions of the Prostate

Aromatherapy in Total Knee Replacement

Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acute Leukemia Undergoing Chemotherapy

Efficacy and Safety of Acute Topical and Aromatic Essential Oil-Based Products for Cognitive Support

Natural Product System and Lifestyle Modification

Essential Oil Inhalation and Acute Stress Response in Healthy Adults

ESSENCE Study: Efficacy and Safety of SD-101 Cream in Participants With Epidermolysis Bullosa

The Effects of VisionPure™ on Indices of Vision Health and Cognitive Function

Mouth Rinses for Inactivation of COVID-19

Olfactory Training in Improving Sense of Smell After Radiation Therapy in Patients With Paranasal Sinus or Nasopharyngeal Cancer

Effects of Aromatherapy on Patient Satisfaction With Surgical Abortion at Less Than 10 Weeks Gestation

Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery