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ClinicalTrials.gov public records Last synced Oct 1, 2026, 2:35 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–71 of 71 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: prazosin hydrochloride Clear all

Conditions: Alcoholism
Interventions: Prazosin medication, Placebo medication; Drug
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Post-Traumatic Headache
Interventions: Prazosin, Placebo; Drug
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years and older
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 2
States / cities: Seattle, Washington • Tacoma, Washington

Conditions: Idiopathic Dilated Cardiomyopathy
Interventions: Carvedilol, Metoprolol succinate, Metoprolol succinate + doxazosin; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2009
U.S. locations: 2
States / cities: Denver, Colorado • Salt Lake City, Utah

Conditions: Alcohol Dependence
Interventions: Prazosin Tablet, Placebo Tablet; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2019
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Stress Disorders, Post-Traumatic
Interventions: prazosin; Drug
Lead sponsor: Rainier Associates; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Tacoma, Washington

Conditions: Cigarette Smoking, Alcohol Use Disorders
Interventions: Varenicline, Prazosin, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Alcohol Abuse, Posttraumatic Stress Disorder
Interventions: Prazosin, Placebo medication; Drug
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Cocaine Dependence
Interventions: Doxazosin, Placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 64 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cardiovascular Diseases, Heart Diseases, Hypertension, Coronary Disease, Myocardial Infarction
Interventions: Chlorthalidone, Lisinopril, Amlodipine, Doxazosin; Drug
Lead sponsor: Donna Arnett, 257-5678; Other
Eligibility: 55 Years and older
Enrollment: 37,939 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2005
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Orthostatic Hypotension, Falls
Interventions: Medication review, Nutrition/Salt intake, Education, Exercise, Drug Recommendations; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 99 Years
Enrollment: 356 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Alzheimer Disease, Psychomotor Agitation
Interventions: prazosin, placebo (inert substance); Drug
Lead sponsor: University of Washington; Other
Eligibility: Not listed
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2009
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Cannabis Dependence, Posttraumatic Stress Disorder, Cannabis Use Disorder
Interventions: Prazosin Hydrochloride; Drug
Lead sponsor: VA Puget Sound Health Care System; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Posttraumatic Stress Disorder
Interventions: Prazosin, Placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years to 75 Years
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Hypertension, Stress, Psychological, Blood Pressure
Interventions: Prazosin, Placebo; Drug
Lead sponsor: Augusta University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: Hypertension, Heart Failure
Interventions: Prazosin HCl 2mg, Prazosin HCl 1 mg, Prazosin HCl 5 mg; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Alcoholism
Interventions: prazosin; Drug
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Stress Disorders, Post-Traumatic, Sleep Disorders
Interventions: prazosin, paroxetine, Placebo; Drug
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 50 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Fort Lewis, Washington

Conditions: Anxiety Disorders, Mood Disorders, Insomnia, Nightmares
Interventions: Behavioral Sleep Intervention, Prazosin, Placebo; Behavioral · Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 55 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cocaine Dependence
Interventions: Doxazosin, Placebo; Drug · Other
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 64 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Posttraumatic Stress Disorder, Alcohol Use Disorders
Interventions: doxazosin, placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Hypertension, COVID
Interventions: ACEI/ARB, Non-ACEI/ARB, ACEI, ARB; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 22,213 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: COVID-19
Interventions: Prazosin, Standard of care; Drug · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 45 Years to 85 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: PTSD
Interventions: doxazosin, Perindopril, Placebo; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Houston, Texas

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Study of the Medication Prazosin for Alcohol Dependence

Prazosin for Post-Concussive Headaches

Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart

Prazosin to Reduce Stress-Induced Alcohol/Drug Craving and Relapse

Feasibility Study: The Effect of Prazosin for Nighttime Symptoms of Civilian PTSD

Varenicline + Prazosin for Heavy Drinking Smokers

Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder

Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse

Genetics of Hypertension Associated Treatments (GenHAT)

Orthostatic Hypotension Treatment on Rehab Unit

Alzheimer's in Long-Term Care--Treatment for Agitation

Reducing Cannabis Overuse With Prazosin

Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests

Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress

Pivotal Bioequivalence Study to Qualify Manufacturing Site Transfer for Prazosin Hydrochloride Capsules

Prazosin Alcohol Dependence IVR Study

Prazosin vs Paroxetine in Combat Stress-Related Post-Traumatic Stress Disorder (PTSD) Nightmares & Sleep Disturbance

Efficacy of Sleep Interventions for Posttraumatic Stress Disorder (PTSD)

The Efficacy of Doxazosin for Cocaine Users

CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders

ACEI or ARB and COVID-19 Severity and Mortality in US Veterans

Prazosin to Prevent COVID-19 (PREVENT-COVID Trial)

DOXAZOSIN FOR PTSD