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ClinicalTrials.gov public records Last synced Oct 28, 2026, 6:01 AM EDT

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Showing 241–264 of 438 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: probiotic Clear all
Completed Phase 4 Interventional

Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

NCT02462590
View directory record Official record
Conditions
Ventilator Associated Pneumonia, Infections, C-Difficile, Antibiotic-associated Diarrhea, Diarrhea
Interventions
L. rhamnosus GG - Probiotic, Placebo - Microcrystalline Cellulose
Drug
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
2,650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Rochester, Minnesota • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 17, 2020 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

The Effects of a Novel Probiotic Supplement on Menopausal Symptoms and Bone Health

NCT04001088
View directory record Official record
Conditions
Menopause
Interventions
Probiotic, Placebo
Dietary Supplement · Other
Lead sponsor
Lallemand Health Solutions
Industry
Eligibility
40 Years to 59 Years · Female only
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
5
States / cities
Lake Worth, Florida • Port Saint Lucie, Florida • Atlanta, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Impact of Emergency Department Probiotic (LGG) Treatment of Pediatric Gastroenteritis

NCT01773967
View directory record Official record
Conditions
Gastroenteritis
Interventions
LGG, micro-crystalline cellulose
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
3 Months to 48 Months
Enrollment
971 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
10
States / cities
Sacramento, California • Washington D.C., District of Columbia • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2019 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Flourish Vaginal Care System to Establish Neovaginal Microbiome

NCT05372770
View directory record Official record
Conditions
Neovaginal Microbiome
Interventions
Flourish Vaginal Care system
Device
Lead sponsor
Vaginal Biome Science
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New Hope, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Phase 2 Interventional

Lactobacillus Johnsonii in Children and Adolescents With T1D

NCT03961854
View directory record Official record
Conditions
Type 1 Diabetes (T1D)
Interventions
L. johnsonii Probiotic, Placebo Capsule
Drug
Lead sponsor
University of Florida
Other
Eligibility
8 Years to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 28, 2026, 6:01 AM EDT
Terminated Not applicable Interventional

Effects of Flourish HEC Vaginal Care System on Birth-Related Pelvic Floor Disorders

NCT05665569
View directory record Official record
Conditions
Pelvic Floor Disorders
Interventions
Flourish HEC, which contains BioNourish, Routine pelvic physical therapy
Device · Other
Lead sponsor
Vaginal Biome Science
Other
Eligibility
18 Years and older · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Bellaire, Texas
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Impact of Oligosaccharides and Bifidobacteria on the Intestinal Microflora of Premature Infants

NCT00810160
View directory record Official record
Conditions
Fecal Microflora in the Formula Fed Premature Infant
Interventions
ProlactPlus, GOS galacto-oligosaccharides, Bifidobacterium infantis, Bifidobacterium animalis
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
Not listed
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2017 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Not applicable Interventional Results available

Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia

NCT01242371
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Probiotic Supplement, Identical-appearing Placebo
Dietary Supplement
Lead sponsor
Sheppard Pratt Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 5, 2019 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Highly Processed Foods and Vascular Health

NCT05628350
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
No UPF controlled diet, High UPF controlled diet
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
40 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 28, 2026, 6:01 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Jump Start Nutrition Program on Weight Loss and Associated Measures

NCT05443269
View directory record Official record
Conditions
Weight Loss
Interventions
Jump Start Nutritional Program
Dietary Supplement
Lead sponsor
University of Memphis
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Oct 28, 2026, 6:01 AM EDT
Not listed Phase 2Phase 3 Interventional

Probiotic (Visbiome) for Gulf War Illness

NCT03078530
View directory record Official record
Conditions
Gulf War Illness
Interventions
Placebo, Visbiome, VSL#3
Drug
Lead sponsor
Ashok Tuteja
Federal
Eligibility
35 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Oct 28, 2026, 6:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Synbiotic to Attenuate Resorption of the Skeleton

NCT06389539
View directory record Official record
Conditions
Osteoporosis, Inflammation, Aging
Interventions
SBD111 medical food, Placebo
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
60 Years and older · Female only
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 28, 2026, 6:01 AM EDT
Terminated Phase 4 Interventional Results available

Study of Probiotic GanedenBC30 for Irritable Bowel Syndrome and Major Depressive Disorder

NCT01337609
View directory record Official record
Conditions
Major Depressive Disorder, Irritable Bowel Syndrome
Interventions
Ganeden BC30, Placebo (sugar pill), Ganeden BC30, Placebo (sugar pill)
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Burlington, Massachusetts • Westborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 9, 2013 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Not applicable Interventional

Efficacy of Probiotic Bacteria in Subjects With IBS or Functional Diarrhea/ Bloating

NCT00618904
View directory record Official record
Conditions
Pain
Interventions
Probiotics - Lactobacillus and bifidobacterium, Placebo
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 75 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 9, 2013 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Not applicable Interventional

Probiotic in Patients With Bile Acid Malabsorption/Diarrhea

NCT06609148
View directory record Official record
Conditions
Bile Acid Malabsorption, Bile Acid Diarrhea
Interventions
De Simone formulation probiotic, Placebo
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Phase 3 Interventional

Lactobacillus GG in the Prophylaxis of Ventilator Associated Pneumonia

NCT00613795
View directory record Official record
Conditions
Pneumonia, Ventilator Associated Pneumonia
Interventions
Lactobacillus GG, placebo
Dietary Supplement
Lead sponsor
Creighton University
Other
Eligibility
19 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 18, 2010 · Synced Oct 28, 2026, 6:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Continuous Yogurt Intake on Immunomodulatory Function and Subjective Health Status in Healthy U.S. Adults

NCT07799207
View directory record Official record
Conditions
Immune Function
Interventions
Yogurt drink, Acidified lactic beverage
Dietary Supplement
Lead sponsor
Meiji Co., Ltd.
Industry
Eligibility
18 Years to 65 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Exercise, Milk Thistle, and Lactobacillus to Influence Plasma Bilirubin

NCT04717726
View directory record Official record
Conditions
Obesity
Interventions
Milk Thistle (MT), Lactobacillus Gasseri (LAC), Exercise (EX), Control (CON)
Dietary Supplement · Behavioral
Lead sponsor
Kyle Flack
Other
Eligibility
18 Years to 50 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress

NCT05392556
View directory record Official record
Conditions
Stress Physiology
Interventions
Probiotic, Prebiotic, Placebo
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 26, 2025 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Phase 2 Interventional Results available

Intravaginal LACTIN-V for Prevention of Recurrent Urinary Tract Infection

NCT00305227
View directory record Official record
Conditions
Urinary Tract Infection
Interventions
Lactin-V, Placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 14, 2023 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Decreasing Rates of Illness in Kids (DRINK)

NCT00356382
View directory record Official record
Conditions
Healthy
Interventions
Lactobacillus (L.) casei
Drug
Lead sponsor
Georgetown University
Other
Eligibility
3 Years to 6 Years
Enrollment
638 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 14, 2008 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of a Novel Nutritional Product on Nutrient Status and Digestive Health

NCT06181214
View directory record Official record
Conditions
Gastrointestinal Microbiome, Nutrition, Healthy, Healthy Aging
Interventions
AG1 - Nutritional Supplement, Placebo
Dietary Supplement
Lead sponsor
Athletic Greens International
Industry
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Canfield, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 22, 2024 · Synced Oct 28, 2026, 6:01 AM EDT
Completed Phase 2 Interventional Results available

Effects of the Probiotic Visbiome Extra Strength on Gut Microbiome & Immune Activation Markers

NCT02706717
View directory record Official record
Conditions
HIV-1 Infection
Interventions
Visbiome Extra Strength, Placebo
Drug
Lead sponsor
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Network
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
24
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Oct 28, 2026, 6:01 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Gut Microbiome Response to Long-Haul Travel in Elite Football Players

NCT07585474
View directory record Official record
Conditions
Microbial Composition, Immune Function
Interventions
Probiotic Capsule, Placebo
Drug
Lead sponsor
Sheffield Hallam University
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 28, 2026, 6:01 AM EDT