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ClinicalTrials.gov public records Last synced Oct 29, 2026, 5:11 AM EDT

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Showing 361–384 of 438 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: probiotic Clear all
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Changes in Amino Acid Absorption After Adding a Probiotic to an Acute Protein Feeding

NCT06701604
View directory record Official record
Conditions
Amino Acid Absorption, Probiotic
Interventions
Single Strain Probiotic + Milk Protein, Placebo + Milk Protein
Dietary Supplement
Lead sponsor
The Archer-Daniels-Midland Company
Industry
Eligibility
18 Years to 35 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Belton, Texas
Source: ClinicalTrials.gov public record
Updated Nov 22, 2024 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Probiotics on Health-related Quality of Life in College Students With Upper Respiratory Infections

NCT01657643
View directory record Official record
Conditions
Upper Respiratory Infection
Interventions
Probiotics, placebo
Dietary Supplement
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 25 Years
Enrollment
231 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Framingham, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Skin Hydration in Adults With Dry Skin Using a Moisturizer With an Added Sterilized Probiotic

NCT05013645
View directory record Official record
Conditions
Dry Skin
Interventions
Sterilized probiotic LfQi601, Placebo
Other
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Mar 21, 2025 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Yogurt Study in Children 2-4 Years Old Attending Daycare

NCT00760851
View directory record Official record
Conditions
Infections, Respiratory, Diarrhea
Interventions
probiotic strain Bb-12, no Bb-12
Other
Lead sponsor
Georgetown University
Other
Eligibility
2 Years to 4 Years
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 18, 2011 · Synced Oct 29, 2026, 5:11 AM EDT
Completed No phase listed Observational

Observational Study of Kibow Biotics in Chronic Kidney Failure Patients

NCT01450657
View directory record Official record
Conditions
Chronic Kidney Failure
Interventions
Kibow Biotics/Renadyl
Dietary Supplement
Lead sponsor
Kibow Pharma
Industry
Eligibility
18 Years to 75 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 18, 2017 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety of Lactobacillus Rhamnosus GG ATCC 53103 (LGG) in Healthy Volunteers

NCT00934453
View directory record Official record
Conditions
Healthy
Interventions
Lactobacillus rhamnosus GG ATCC 53103, Placebo
Biological
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 29, 2026, 5:11 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID

NCT06560554
View directory record Official record
Conditions
Long COVID
Interventions
Fermented foods, Control
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Phase 2 Interventional Results available

The Probiotic Study: Using Bacteria to Calm Your Mind

NCT02711800
View directory record Official record
Conditions
Anxiety, Abdominal Pain
Interventions
Lactobacillus rhamnosus
Drug
Lead sponsor
Nancy Zucker
Other
Eligibility
9 Years to 13 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

BacterioPHAGE for Gastrointestinal Health 2 Study

NCT04511221
View directory record Official record
Conditions
Mild Gastrointestinal Symptoms in Healthy Adults
Interventions
Bifidobacterium animals subsp. lactis BL04+PreforPro, Bifidobacterium animals subsp. lactis BL04, Placebo
Dietary Supplement · Other
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 65 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 13, 2020 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Early Phase 1 Interventional

Safety, Tolerability, and Pharmacodynamics of SYNB8802v1 in Subjects With History of Gastric Bypass Surgery or Short-bowel Syndrome

NCT05377112
View directory record Official record
Conditions
Enteric Hyperoxaluria
Interventions
SYNB8802v1, Placebo
Drug · Other
Lead sponsor
Synlogic
Industry
Eligibility
18 Years to 74 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2023 · Synced Oct 29, 2026, 5:11 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Clinical Study to Assess the Effects of Prebiotic and Probiotic Supplement

NCT06794619
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Dietary Supplement with actives
Dietary Supplement
Lead sponsor
Olly, PBC
Industry
Eligibility
18 Years to 50 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Correlating Probiotic Dietary Supplements During Pregnancy With Maternal Microbiome Profiles

NCT03611647
View directory record Official record
Conditions
Pregnancy Related
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
3
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Probiotic Blend Reduces Gastrointestinal Symptoms and Positively Impacts Microbiota Modulation in a Randomized Study

NCT05614726
View directory record Official record
Conditions
Microbiota, Constipation, Candida
Interventions
575mg [30 billion colony forming units] probiotic blend of Bifidobacterium breve, Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, Saccharomyces boulardii, and alpha amylase
Dietary Supplement
Lead sponsor
The Center for Applied Health Sciences, LLC
Industry
Eligibility
30 Years to 60 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Canfield, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotics in Occupational Shift Workers

NCT02951689
View directory record Official record
Conditions
Shift-Work Related Sleep Disturbance, Healthy
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
22 Years to 55 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

The PRIDE Study Probiotics on Regulation and Improving Digestive hEalth

NCT01203462
View directory record Official record
Conditions
Digestive Irregularity, Digestive Discomfort, History of Straining During Bowel Movements, History of Hard or Lumpy Stools
Interventions
Probiotic strain of Bifidobacterium, No Bifidobacterium
Other
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 11, 2013 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional

Role of Probiotics in Treatment of Pediatric NAFLD Patients by Assessing With Fibroscan

NCT04671186
View directory record Official record
Conditions
Non-Alcoholic Fatty Liver Disease
Interventions
Culturelle (Lactobacillus rhamnosus strain GG), Placebo
Dietary Supplement · Other
Lead sponsor
Northwell Health
Other
Eligibility
5 Years to 18 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2023 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of a Probiotic Supplement

NCT05425329
View directory record Official record
Conditions
Gastrointestinal Discomfort
Interventions
I3.1, Placebo treatment
Dietary Supplement
Lead sponsor
University of Memphis
Other
Eligibility
20 Years to 50 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 21, 2022 · Synced Oct 29, 2026, 5:11 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Jump Start Nutrition Program on Weight Loss and Associated Measures

NCT05443269
View directory record Official record
Conditions
Weight Loss
Interventions
Jump Start Nutritional Program
Dietary Supplement
Lead sponsor
University of Memphis
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Oct 29, 2026, 5:11 AM EDT
Enrolling by invitation Phase 4 Interventional

Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee

NCT06636669
View directory record Official record
Conditions
Prosthetic-joint Infection, Dysbiosis
Interventions
Probiotic, Standard of care
Drug · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Gastric Acid Suppression and Probiotic Colonization

NCT03327051
View directory record Official record
Conditions
Probiotics
Interventions
Omeprazole, VSL #3, Placebo
Drug · Dietary Supplement
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 75 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Oct 29, 2026, 5:11 AM EDT
Active, not recruiting Not applicable Interventional

Impact of Lp299v on Vascular Function in Patients With PASC

NCT05227170
View directory record Official record
Conditions
COVID-19
Interventions
Lactobacillus Plantarum 299v Freeze Dried Capsule, Freeze Dried Potato Starch Capsule
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 89 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Active, not recruiting Phase 1 Interventional

CBM588 in Improving Clinical Outcomes in Patients Who Have Undergone Donor Hematopoietic Stem Cell Transplant

NCT03922035
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm
Interventions
Best Practice, Clostridium butyricum CBM 588 Probiotic Strain
Other · Drug
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of a Dietary Supplement Versus Placebo on Serum PFAS Levels in Male Firefighters

NCT07846371
View directory record Official record
Conditions
Environmental Exposure, PFAS Exposure
Interventions
Streptococcus salivarius 46-SL1, Placebo
Dietary Supplement
Lead sponsor
Cambiotics ApS
Industry
Eligibility
18 Years and older · Male only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Lactobacillus Probiotic for Prevention of UTI

NCT03151967
View directory record Official record
Conditions
Urinary Tract Infections (UTI's)
Interventions
Lactobacillus crispatus CTV-05, Placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Oct 29, 2026, 5:11 AM EDT