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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: prolonged exposure Clear all
Completed Not applicable Interventional Results available

Treatment of Prolonged Grief Disorder in Combat Veterans

NCT02283333
View directory record Official record
Conditions
Prolonged Grief Disorder
Interventions
BATE-G, Standard Treatment
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
2
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 17, 2021 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Early Phase 1 Interventional

Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury

NCT04280965
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Quetiapine Fumarate, Standard of care meducations
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Not applicable Interventional

Evaluating the Feasibility of RESCUE: An Adjunctive HAI-Based Intervention for Veterans With PTSD

NCT03504722
View directory record Official record
Conditions
PTSD
Interventions
RESCUE, Prolonged Exposure
Behavioral
Lead sponsor
Charleston Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Sep 23, 2026, 10:31 AM EDT
Recruiting Not applicable Interventional

Evaluating Treatments for Suicidal Veterans With PTSD

NCT05974631
View directory record Official record
Conditions
Self-directed Violence, Post-traumatic Stress Disorder (PTSD)
Interventions
Dialectical Behavior Therapy, Dialectical Behavior Therapy Prolonged Exposure protocol, Prolonged Exposure therapy, Suicide risk management
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
4
States / cities
Minneapolis, Minnesota • Durham, North Carolina • San Antonio, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Not applicable Interventional

Telemedicine for Improved Delivery of Psychosocial Treatments for Post Traumatic Stress Disorder

NCT01158001
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Depression, Anxiety
Interventions
Prolonged exposure therapy
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2015 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Phase 2Phase 3 Interventional

RECONsolidation of Traumatic Memories to ResOLve Post Traumatic Stress Disorder (RECONTROLPTSD)

NCT03827057
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Traumatic Brain Injury
Interventions
Reconsolidation of Traumatic Memories (RTM), Prolonged Exposure (PE)
Behavioral
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Phase 2 Interventional Results available

Treatment of Smoking Among Individuals With PTSD

NCT00937235
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence, Post-traumatic Stress Disorder, Tobacco Use Disorder
Interventions
Varenicline, Medication Management Counseling, Prolonged Exposure
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2017 · Synced Sep 23, 2026, 10:31 AM EDT
Not listed Phase 3 Interventional

A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder

NCT00978484
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Virtual Reality Exposure Therapy - Dynamic, Augmented Exposure Therapy
Behavioral
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
2
States / cities
Camp Pendlton, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2014 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Not applicable Interventional

Psychotherapy for PTSD Among Veterans Also Receiving Drug or Alcohol Treatment

NCT04581434
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Substance Use Disorders
Interventions
Prolonged Exposure Therapy, Cognitive Processing Therapy, Present Centered Therapy
Behavioral
Lead sponsor
Center for Veterans Research and Education
Other
Eligibility
18 Years and older
Enrollment
426 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
14
States / cities
San Diego, California • Tampa, Florida • Atlanta, Georgia + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Phase 2 Interventional

Relationship Between the Biological and Psychological Correlates of PTSD

NCT00183300
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Prolonged Exposure Therapy
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 5, 2015 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Not applicable Interventional

Efficacy of 60-minute Versus 90-minute Sessions in Treating PTSD Using Prolonged Exposure

NCT01911585
View directory record Official record
Conditions
Posttraumatic Stress Disorder, PTSD
Interventions
Prolonged Exposure Therapy
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Sep 23, 2026, 10:31 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

TDCS-Augmented Prolonged Exposure Therapy

NCT04327362
View directory record Official record
Conditions
Posttraumatic Stress Disorder, PTSD, Anxiety, Depression
Interventions
Transcranial Direct Current Stimulation (tDCS), Prolonged Exposure Therapy
Device · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 23, 2026, 10:31 AM EDT
Recruiting Not applicable Interventional

Massed Prolonged Exposure for PTSD in Substance Use Treatment

NCT06296186
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Substance Use Disorders
Interventions
Prolonged Exposure Therapy
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
6
States / cities
San Diego, California • Tampa, Florida • Atlanta, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Not applicable Interventional

The Role of Exercise in the Treatment of PTSD Symptoms

NCT02649127
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
imaginal therapy, exercise, self-care
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2017 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Not applicable Interventional

Project Remission: Maximizing Outcomes With Intensive Treatments for Combat-Related PTSD

NCT03529435
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Massed Prolonged Exposure, Intensive Outpatient Prolonged Exposure
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
4
States / cities
Fort Hood, Texas • San Antonio, Texas • Waco, Texas
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 23, 2026, 10:31 AM EDT
Recruiting Not applicable Interventional

Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure

NCT06296589
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Trauma Informed Guilt Reduction Therapy, Prolonged Exposure Therapy
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Little Rock, Arkansas • San Diego, California • New Orleans, Louisiana + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 23, 2026, 10:31 AM EDT
Terminated Phase 3 Interventional Results available

Combined Treatment of Prolonged Exposure and Pramipexole for Posttraumatic Stress Disorder and Depression

NCT03765138
View directory record Official record
Conditions
PTSD, MDD
Interventions
PE/Pramipexole
Combination Product
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years to 60 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 25, 2019 · Synced Sep 23, 2026, 10:31 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Structure and Function Before and After Treatment for Post-Traumatic Stress Disorder

NCT00069225
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 23, 2026, 10:31 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Randomized Clinical Trial of Hydrocortisone Augmentation of Prolonged Exposure

NCT01525680
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Hydrocortisone augmented Prolonged Exposure Therapy, Prolonged exposure therapy with placebo administration
Other
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
18 Years to 89 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2011
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 27, 2013 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Not applicable Interventional

Innovative Delivery of Evidence Based Psychotherapy to Women With Military Sexual Trauma

NCT02417025
View directory record Official record
Conditions
PTSD, Stress Disorders, Post - Traumatic, Anxiety Disorders, Mental Disorders, Stress Disorders, Traumatic
Interventions
PE
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older · Female only
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Sep 23, 2026, 10:31 AM EDT
Not listed Phase 2 Interventional

Comparison of Methods for the Delivery of Interoceptive Exposure

NCT01201304
View directory record Official record
Conditions
Anxiety Sensitivity
Interventions
Standard exposure, Enhanced exposure, Intensive exposure, Expressive writing
Behavioral
Lead sponsor
University of Wyoming
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Laramie, Wyoming
Source: ClinicalTrials.gov public record
Updated Jan 30, 2012 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Not applicable Interventional Results available

PTSD (PostTraumatic Stress Disorder) Services for Veterans With SMI (Severe Mental Illness)

NCT01542229
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
Interventions
Prolonged Exposure for PTSD (PE) + Treatment as Usual (TAU), Treatment As Usual (TAU)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 14, 2019 · Synced Sep 23, 2026, 10:31 AM EDT
Recruiting Not applicable Interventional

Shared Decision Making in PTSD Treatment

NCT06953687
View directory record Official record
Conditions
Post Traumatic Stress Disorder PTSD
Interventions
Prolonged Exposure Therapy, Cognitive Processing Therapy, Written Exposure Therapy, Shared Decision Making (SHARE)
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Fort Hood, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 23, 2026, 10:31 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Topiramate and Prolonged Exposure

NCT03176953
View directory record Official record
Conditions
PTSD and Alcohol Use Disorder
Interventions
topiramate, prolonged exposure, placebo
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 23, 2026, 10:31 AM EDT