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Showing 25–43 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: pupillometry Clear all
Recruiting Not applicable Interventional

A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)

NCT06507748
View directory record Official record
Conditions
Neurofibromatosis Type 1
Interventions
AlgometRx Nociometer
Device
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
1 Year to 120 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 8, 2026, 3:27 PM EDT
Enrolling by invitation Not applicable Interventional

Cortical Contributions to FFR: Post-Op Outcomes

NCT05214092
View directory record Official record
Conditions
Language
Interventions
Speech sound stimulation
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years to 25 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 8, 2026, 3:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Clear Speech on Listening Effort and Memory in Sentence Processing

NCT06053190
View directory record Official record
Conditions
Speech, Memory, Delayed, Sensorineural Hearing Loss
Interventions
Sentence stimulus, Speaking style
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
60 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 12, 2025 · Synced Sep 8, 2026, 3:27 PM EDT
Completed Not applicable Interventional

Optimal Time for In-situ Dry Needling to Affect the Autonomic Nervous System

NCT03728751
View directory record Official record
Conditions
Healthy
Interventions
Dry needling
Procedure
Lead sponsor
Florida Gulf Coast University
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Hobart, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 1, 2018 · Synced Sep 8, 2026, 3:27 PM EDT
Completed No phase listed Observational

Refractive and Visual Outcomes With the ARGOS Biometer In Eyes With a History of Refractive Surgery: ARGOS Study

NCT07129980
View directory record Official record
Conditions
Cataract
Interventions
ARGOS Biometer
Device
Lead sponsor
Vance Thompson Vision
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Aug 23, 2025 · Synced Sep 8, 2026, 3:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cochlear Implants and Listening Effort: the Interaction of Cognitive and Sensory Constraints

NCT07279441
View directory record Official record
Conditions
Cochlear Implant Users
Interventions
Experiment 1: Syntactic and Semantic Context, Experiment 2: False Hearing and Context Overuse, Experiment 3: Two-Sentence Problem, Experiment 4: Cascading Effects on Discourse Comprehension, Experiment 5: Self-Paced Discourse Comprehension, Experiment 6: Clinical Application
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 80 Years
Enrollment
460 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
2
States / cities
Waltham, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Sep 8, 2026, 3:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Sevoflurane and Propofol on Light Flash Evoked Pupillometry

NCT00695890
View directory record Official record
Conditions
Measurement of Pupil Diameter
Interventions
Not listed
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Sep 8, 2026, 3:27 PM EDT
Not listed No phase listed Observational

Chromatic Pupillometry to Assess the Melanopsin-Light Pathway in Progressive Supranuclear Palsy

NCT03330353
View directory record Official record
Conditions
PSP - Progressive Supranuclear Palsy, PD - Parkinson's Disease, AD - Alzheimer's Disease, ALS (Amyotrophic Lateral Sclerosis)
Interventions
Pupillometry
Diagnostic Test
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
55 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Sep 8, 2026, 3:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cortical Contributions to Frequency Following Responses and Modulation

NCT05010473
View directory record Official record
Conditions
Language
Interventions
Speech and non-speech sound stimulation
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
13 Years to 25 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 8, 2026, 3:27 PM EDT
Not listed No phase listed Observational

Pupillometry for the Prediction of Neurologic Outcomes in Severe Traumatic Brain Injury

NCT02465242
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 27, 2016 · Synced Sep 8, 2026, 3:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

QST-Pupillometry in Sickle Cell Disease Patients

NCT02242058
View directory record Official record
Conditions
SCD With Severe Phenotype (HbSS, HbSβ0 Thalassemia, HbSOARab)
Interventions
Quantitative sensory testing
Other
Lead sponsor
Julia Finkel
Other
Eligibility
13 Years to 30 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 8, 2026, 3:27 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Utility of Pupillary Metrics in Diagnosis and Management of Concussion in Children

NCT04540445
View directory record Official record
Conditions
Brain Concussion, Reflex, Pupillary, Post-Concussion Syndrome, Brain Injuries, Traumatic
Interventions
Pupillary Assessment
Other
Lead sponsor
Children's Hospital of Orange County
Other
Eligibility
5 Years to 17 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Sep 8, 2026, 3:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Rapid, Non-invasive, Regional Functional Imaging of the Retina. (Diabetic Retinopathy Diagnosis Device)

NCT01546766
View directory record Official record
Conditions
Diabetes, Retinal Disorders
Interventions
Pupillometry testing.
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2015
U.S. locations
2
States / cities
Los Angeles, California • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 6, 2023 · Synced Sep 8, 2026, 3:27 PM EDT
Recruiting No phase listed Observational

Measuring Analgesic Interventions

NCT03794362
View directory record Official record
Conditions
Pain
Interventions
Not listed
Lead sponsor
Julia Finkel
Other
Eligibility
7 Years to 21 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 8, 2026, 3:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

NCT02535702
View directory record Official record
Conditions
Normal Physiology
Interventions
In vivo MRS, fMRI, EEG/EOG, Stimulation tasks, NSPRD, Structural MRI
Other
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 8, 2026, 3:27 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Pupillometry and Locus Coeruleus Activation (PuLCA)

NCT04579653
View directory record Official record
Conditions
Visual Impairment, Ocular Illness
Interventions
transcutaneous electrical nerve stimulation devices
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 30 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 8, 2026, 3:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Listening Effort on Sentence Processing and Memory (Study 1)

NCT05584514
View directory record Official record
Conditions
Sentence Stimulus, Auditory Noise
Interventions
Sentence Stimulus, Auditory Noise
Other
Lead sponsor
University of Utah
Other
Eligibility
60 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 8, 2026, 3:27 PM EDT
Completed Phase 4 Interventional Results available

Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia

NCT01325493
View directory record Official record
Conditions
Idiopathic Scoliosis, Spondylolisthesis
Interventions
Ketamine, Normal Saline
Drug
Lead sponsor
Julia Finkel
Other
Eligibility
10 Years to 18 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Sep 8, 2026, 3:27 PM EDT
Recruiting Not applicable Interventional

Pupillometry in Delayed Sleep Wake Phase Disorder

NCT06949644
View directory record Official record
Conditions
Delayed Sleep-Wake Phase Disorder
Interventions
Light and Citalopram
Combination Product
Lead sponsor
Northwestern University
Other
Eligibility
16 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 8, 2026, 3:27 PM EDT