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Showing 1–24 of 166 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: saline nasal irrigation Clear all
Withdrawn Phase 2Phase 3 Interventional Accepts healthy volunteers

Impact of Budesonide Irrigations on Patients With Chronic Rhinosinusitis and Impact on Sinus Surgery Rates

NCT03519061
View directory record Official record
Conditions
Chronic Sinus Infection, Chronic Sinusitis, Chronic Sinusitis - Ethmoidal, Posterior, Chronic Sinus Congestion
Interventions
Budesonide
Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jan 13, 2021 · Synced Sep 24, 2026, 10:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of Airway Obstruction in Infants With Lower Respiratory Infections

NCT00435994
View directory record Official record
Conditions
Bronchiolitis, Respiratory Syncytial Virus Infections
Interventions
Inhaled primatene will be given as a breathing treatment, Nasal Washing
Drug · Other
Lead sponsor
Indiana University
Other
Eligibility
2 Months to 2 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 31, 2016 · Synced Sep 24, 2026, 10:13 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Rate of Total Joint Infection 90-day After Surgery Following Irrigation With Next Science No-Rinse Solution vs SOC Alone

NCT05519007
View directory record Official record
Conditions
Joint Infection
Interventions
No-Rinse Solution (NS), Saline irrigation
Other
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
936 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
3
States / cities
Manhasset, New York • New Hyde Park, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Sep 24, 2026, 10:13 PM EDT
Completed Not applicable Interventional Results available

Antibiotic Irrigation for Pancreatoduodenectomy

NCT02186457
View directory record Official record
Conditions
Surgery, Infection
Interventions
Polymyxin B in Normal Saline, Placebo: Normal Saline
Drug · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 88 Years
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 22, 2022 · Synced Sep 24, 2026, 10:13 PM EDT
Completed Phase 3 Interventional Results available

Safety, Efficacy and Pharmacokinetics of OMS302 in Subjects Undergoing Intraocular Lens Replacement With Phacoemulsification

NCT01579565
View directory record Official record
Conditions
Intraocular Lens Replacement
Interventions
OMS302, Placebo
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
18 Years and older
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
13
States / cities
Chandler, Arizona • Los Angeles, California • Fort Myers, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2017 · Synced Sep 24, 2026, 10:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intra-abdominal at Cesarean Section: A Randomized Controlled Trial

NCT01479712
View directory record Official record
Conditions
Nausea, Vomiting
Interventions
Normal Saline Irrigation
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
263 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 23, 2011 · Synced Sep 24, 2026, 10:13 PM EDT
Not listed Not applicable Interventional

Effectiveness for Interventions to Minimize Surgical Site Infections

NCT01153191
View directory record Official record
Conditions
Infections
Interventions
Normal saline pressurized irrigation, sub-q gentamicin
Procedure · Drug
Lead sponsor
Dallas VA Medical Center
Federal
Eligibility
18 Years to 95 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 3, 2011 · Synced Sep 24, 2026, 10:13 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Internal Irrigation Surgery

NCT07715825
View directory record Official record
Conditions
Dental Implant Healing, Partial Edentulism Class 1, Partial Edentulism Class II, Partial Edentulism Class 3
Interventions
Irrigation-Integrated Surgical Guide, Conventional Surgical Guide
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
25 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 24, 2026, 10:13 PM EDT
Terminated Not applicable Interventional

Clinical Assessment of Next Science Solution on Gustilo and Anderson Type II and IIIA or IIIB Tibial Fractures

NCT04906642
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Next Science, Standard of Care
Device · Other
Lead sponsor
Next Science TM
Industry
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
Birmingham, Alabama • Columbus, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Sep 24, 2026, 10:13 PM EDT
Terminated Not applicable Interventional Results available

The Effect Of Wound Irrigation With Irrisept™ Delivery System On Abscess Healing In Patients Presenting To The Emergency Department

NCT01302548
View directory record Official record
Conditions
Abscess
Interventions
IRRISEPT, Usual Care
Device · Procedure
Lead sponsor
University of Florida
Other
Eligibility
12 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 6, 2014 · Synced Sep 24, 2026, 10:13 PM EDT
Recruiting Not applicable Interventional

Physical Therapy Wound Care Modalities in Patients With Spinal Cord Injury (SCI)

NCT05458947
View directory record Official record
Conditions
Spinal Cord Injuries, Pressure Injuries
Interventions
pulsed wound irrigation (PWI), electrical stimulation (ES), electrical stimulation (ES) and pulsed wound irrigation (PWI)
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 24, 2026, 10:13 PM EDT
Terminated Not applicable Interventional Results available

VAC Bioburden Wound Care Assessment

NCT04826965
View directory record Official record
Conditions
Upper Extremity Wound, Lower Extremity Wound, Soft Tissue Abscesses, Traumatic Wounds
Interventions
Wound Vac is applied
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Sep 24, 2026, 10:13 PM EDT
Enrolling by invitation Phase 4 Interventional Accepts healthy volunteers

Can Intraosseous Antibiotics Improve the Results of Irrigation & Debridement and Prosthetic Retention for PJI?

NCT03713528
View directory record Official record
Conditions
Joint Infection
Interventions
Intraoperative Intraosseous Vancomycin
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
10
States / cities
San Francisco, California • Gainesville, Florida • Weston, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 24, 2026, 10:13 PM EDT
Not yet recruiting Not applicable Interventional

Feasibility of HISA During TURBT for NMIBC

NCT07817173
View directory record Official record
Conditions
Bladder Cancer, Bladder (Urothelial, Transitional Cell) Cancer Resectable (Pre-Cystectomy), Non-muscle Invasive Bladder Cancer (NMIBC), Non-Muscle Invasive Bladder Neoplasms, Non-muscle Invasive Bladder Cancer, Bladder Cancer (BC), Transurethral Resection of Bladdertumors, Transurethral Resection of the Bladder, Non-Muscle Invasive Bladder Carcinoma
Interventions
HISA
Device
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years to 89 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 24, 2026, 10:13 PM EDT
Not listed Phase 4 Interventional

INtravitreal and Aqueous Dexamethasone Levels After DEXtenza

NCT04529512
View directory record Official record
Conditions
Ocular Disease Requiring Surgery
Interventions
DEXTENZA®
Drug
Lead sponsor
Nathan Steinle
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
3
States / cities
Paso Robles, California • San Luis Obispo, California • Santa Maria, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Sep 24, 2026, 10:13 PM EDT
Recruiting Not applicable Interventional

Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery

NCT05659524
View directory record Official record
Conditions
Pituitary Tumor
Interventions
Nasal saline irrigation
Other
Lead sponsor
Lori Wood
Other
Eligibility
19 Years to 85 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
2
States / cities
Phoenix, Arizona • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Sep 24, 2026, 10:13 PM EDT
Completed Phase 1 Interventional

Evaluation of Endoscopic Surgical Field Clarity Using Hot Saline Versus Lactated Ringer's Irrigation

NCT05161780
View directory record Official record
Conditions
Irrigation
Interventions
Lactated Ringer's Irrigation, Normal Saline
Drug
Lead sponsor
Carl Snyderman
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Sep 24, 2026, 10:13 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Lungs of Normal Individuals by Lung Lavage, Brushing and Bronchial Wall Biopsy

NCT00224185
View directory record Official record
Conditions
Smoking, Lung Diseases
Interventions
Bronchopulmonary Lung Lavage, Bronchial Brushing, Bronchial Wall Biopsy
Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
196 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2016 · Synced Sep 24, 2026, 10:13 PM EDT
Completed Phase 2 Interventional Results available

Smell in COVID-19 and Efficacy of Nasal Theophylline (SCENT 3)

NCT05947643
View directory record Official record
Conditions
COVID-19
Interventions
theophylline, Placebo
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Sep 24, 2026, 10:13 PM EDT
Withdrawn Not applicable Interventional

Continuous Bladder Irrigation Following Transurethral Resection of Bladder Tumors

NCT03839472
View directory record Official record
Conditions
Non-muscle Invasive Bladder Cancer (NMIBC), Bladder Tumor (TURBT)
Interventions
CBI
Procedure
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Sep 24, 2026, 10:13 PM EDT
Completed Not applicable Interventional Results available

Quantitative Characterization of Safe Irrigation for Ventricular Shunt Catheters

NCT02651337
View directory record Official record
Conditions
Hydrocephaly
Interventions
Cerebrospinal Fluid (CSF) Drainage
Device
Lead sponsor
Alcyone Therapeutics, Inc
Industry
Eligibility
30 Days to 35 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 20, 2020 · Synced Sep 24, 2026, 10:13 PM EDT
Completed Not applicable Interventional

A Study to Determine the Effectiveness of Utilizing Intraperitoneal Bupivacaine

NCT03004222
View directory record Official record
Conditions
Laparoscopic Appendectomy
Interventions
Bupivacaine, Placebos
Drug
Lead sponsor
Metro Health, Michigan
Other
Eligibility
18 Years and older
Enrollment
137 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Wyoming, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Sep 24, 2026, 10:13 PM EDT
Recruiting Phase 2Phase 3 Interventional

Tranexamic Acid to Reduce Blood Loss in Spine Surgery

NCT02314988
View directory record Official record
Conditions
Spinal Injuries, Spinal Deformity
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 80 Years
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
4
States / cities
San Francisco, California • Louisville, Kentucky • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 24, 2026, 10:13 PM EDT
Terminated Not applicable Interventional Results available

Impact of Chemokine Receptor 5 (CCR5) Inhibition on Sarcoidosis Immunophenotypes

NCT02134717
View directory record Official record
Conditions
Sarcoidosis
Interventions
all subjects will receive maraviroc 300mg orally twice a day for 6 weeks, Bronchoscopy with bronchoalveolar lavage, venipunctures, Skin biopsy
Drug · Procedure
Lead sponsor
Kevin F. Gibson
Other
Eligibility
18 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Sep 24, 2026, 10:13 PM EDT