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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:42 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 216 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: sertraline (Zoloft) Clear all

Conditions: Major Depressive Disorder
Interventions: Sertraline, Bupropion; Drug
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Myelodysplastic Syndromes
Interventions: Sertraline, Bone Marrow Aspirate/Biopsy; Drug · Procedure
Lead sponsor: Gustavo Rivero; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Houston, Texas

Conditions: Depression
Interventions: Placebo, identified as placebo to participants, Celexa or other antidepressant as clinically indicated, Placebo, identifed to participants as "Active medication"; Other · Drug
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 60 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Alcoholism, Depression
Interventions: naltrexone (Revia), sertraline (Zoloft), Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 171 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms, Type 2 Diabetes, PreDiabetes, Insulin Resistance
Interventions: Good Days Ahead (GDA), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications, Active Control; Behavioral · Drug · Other
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Bipolar Affective Disorders, Cyclothymic Disorder, Schizoaffective Disorder, Major Depressive Disorder, Dysthymic Disorder, Obsessive-Compulsive Disorder, Panic Disorder, Posttraumatic Stress Disorder, Premenstrual Dysphoric Disorder, Social Anxiety Disorder
Interventions: Not listed
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Heart Failure, Depression
Interventions: Cognitive Behavior Therapy, Heart Failure Self-care Education; Behavioral · Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 30 Years and older
Enrollment: 158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Acute Coronary Syndrome, Depressive Symptoms
Interventions: Cognitive Behavioral Therapy (CBT), Antidepressant Medication, Standard Care, Depressive symptom screener, No intervention; Other · Drug
Lead sponsor: Columbia University; Other
Eligibility: 21 Years and older
Enrollment: 1,501 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2019
U.S. locations: 4
States / cities: Bloomington, Minnesota • New York, New York • Henderson, North Carolina + 1 more

Conditions: Social Phobia, Generalized Anxiety Disorder, Separation Anxiety Disorder
Interventions: Sertraline; Drug
Lead sponsor: University of Michigan; Other
Eligibility: 7 Years to 19 Years
Enrollment: 156 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Major Depression
Interventions: Triiodothyronine, Placebo, Sertraline; Drug · Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 2003
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Depression
Interventions: Sertraline; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 60 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2012
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Major Depressive Disorder
Interventions: LY2216684, Sertraline; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Daytona Beach, Florida

Conditions: Sexual Dysfunction, Major Depressive Disorder
Interventions: Vilazodone, Sertraline; Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 3
States / cities: Philadelphia, Pennsylvania • Charlottesville, Virginia

Conditions: Post-Traumatic Stress Disorder
Interventions: sertraline and risperidone; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 2
States / cities: Atlanta, Georgia • Charleston, South Carolina

Conditions: Post-Traumatic Stress Disorder
Interventions: Sertraline, Cognitive behavioral therapy (CBT); Drug · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 55 Years
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Obsessive-Compulsive Disorder
Interventions: Cognitive Behavior Therapy, Educational Support, Sertraline; Behavioral · Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 8 Years to 16 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2002
U.S. locations: 2
States / cities: Durham, North Carolina • Philadelphia, Pennsylvania

Conditions: Psychotic Depression
Interventions: Sertraline + Olanzapine, Sertraline + Placebo; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 269 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 3
States / cities: Worcester, Massachusetts • White Plains, New York • Pittsburgh, Pennsylvania

Conditions: Alcoholism, Depression
Interventions: sertraline (Zoloft), cognitive behavior therapy; Drug · Behavioral
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Ends 2002
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Anxiety Disorders
Interventions: Sertraline; Drug
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 55 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Posttraumatic Stress Disorder
Interventions: Mirtazapine, Sertraline, Sugar pill; Drug · Other
Lead sponsor: Research Foundation for Mental Hygiene, Inc.; Other
Eligibility: 18 Years to 75 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder (MDD)
Interventions: SSRI (escitalopram or sertraline), Extended-Release Memantine, Placebo; Drug
Lead sponsor: Jeffrey Miller; Other
Eligibility: 18 Years to 50 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Acute Myeloid Leukemia
Interventions: Sertraline, Cytosine arabinoside, allogeneic stem cell transplantation; Drug · Procedure
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 2
States / cities: Baltimore, Maryland • New York, New York

Conditions: Major Depressive Disorder
Interventions: SPD489 (Lisdexamfetamine dimesylate ), Placebo; Drug
Lead sponsor: Shire; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 1,262 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 47
States / cities: Birmingham, Alabama • Carson, California • Irvine, California + 42 more

Conditions: Obsessive Compulsive Disorder
Interventions: sertraline, psychotherapy; Drug · Behavioral
Lead sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.; Industry
Eligibility: 6 Years to 16 Years
Enrollment: 941 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2020
U.S. locations: 44
States / cities: Dothan, Alabama • Imperial, California • Los Angeles, California + 39 more

Search by objective public record fields.

SMART Trial to Predict Anhedonia Response to Antidepressant Treatment

Sertraline in Treatment of Low-Risk Myelodysplastic Syndrome

Predictors of Antidepressant Response

Sertraline for Alcohol Dependence and Depression

eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk

The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels

Depression and Self-care in Heart Failure

Comparison of Depression Identification After Acute Coronary Syndrome: Quality of Life and Cost Outcomes

Brain Markers of Anxiety Disorders and SSRI/CBT Treatment in Children and Adolescents

Thyroid Medication and Antidepressants for Treating Major Depression

Late-life Depression and Cerebral Perfusion

A Pharmacokinetic Study of the Coadministration of LY2216684 With Sertraline

Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?

Risperidone Augmentation for PTSD

Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder

Treatment of Obsessive-Compulsive Disorder (OCD) in Children

Sustaining Remission of Psychotic Depression

Sertraline and Cognitive Therapy in Depressed Alcoholics

Identifying Brain and Genetic Markers of Sertraline Treatment Response in People With Social Anxiety Disorder

Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial

Pattern Separation in Major Depressive Disorder

Sertraline and Cytosine Arabinoside in Adults With Relapsed and Refractory AML

Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

Sertraline Pediatric Registry for the Evaluation of Safety (SPRITES)