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Showing 1–24 of 33 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: silicone gel Clear all
Completed No phase listed Observational

Evaluating the Effectiveness and Outcomes of Silicone Breast Prosthetics

NCT00594490
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2013
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Sep 5, 2026, 9:04 AM EDT
Recruiting Not applicable Interventional

Silicone Gel vs. Estrogen Vaginal Cream for the Management of Genitourinary Syndrome of Menopause

NCT05672901
View directory record Official record
Conditions
Genitourinary Syndrome of Menopause
Interventions
StrataMGT, Estrace 0.01% Vaginal Cream
Device · Drug
Lead sponsor
Stratpharma AG
Industry
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Laguna Hills, California • Miami, Florida • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 5, 2026, 9:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Silicone Gel for Postsurgical Scars of the Eyelid

NCT03601247
View directory record Official record
Conditions
Scarring Due to Treatment
Interventions
silicone gel
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 5, 2026, 9:04 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

CPG Styles Study: A Study of the Safety of the Contour Profile Gel Breast Implants (CPG Styles Study)

NCT01959880
View directory record Official record
Conditions
Breast Augmentation, Breast Reconstruction, Breast Revision
Interventions
The Contour Profile Gel (CPG) breast implants
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older · Female only
Enrollment
1,891 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Nov 10, 2016 · Synced Sep 5, 2026, 9:04 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Sientra Post-Approval Study

NCT01639053
View directory record Official record
Conditions
Breast Augmentation, Breast Reconstruction, Breast Revision
Interventions
Not listed
Lead sponsor
Tiger Biosciences, LLC.
Industry
Eligibility
18 Years and older · Female only
Enrollment
5,498 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2025
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 5, 2026, 9:04 AM EDT
No Longer Available No phase listed Expanded access

Compassionate Use of the Becker Expander/Breast Implant

NCT01000012
View directory record Official record
Conditions
Breast Reconstruction
Interventions
Becker 50 Expander/Breast implant, Becker 25 Expander/Breast implant
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older · Female only
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2013 · Synced Sep 5, 2026, 9:04 AM EDT
Recruiting Phase 1 Interventional

StrataMGT in the Reduction of Vulvar Lichen Sclerosus (LS) Symptoms

NCT06662942
View directory record Official record
Conditions
Vulvar Lichen Sclerosus
Interventions
StrataMGT, Placebo
Drug
Lead sponsor
Andrew T. Goldstein, MD
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Tampa, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 7, 2024 · Synced Sep 5, 2026, 9:04 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Motiva Implants® Post-Approval Study

NCT06938399
View directory record Official record
Conditions
Breast Implant
Interventions
Silicone gel-filled breast implants - Motiva Implants®, Aesthetic Surgery
Device · Other
Lead sponsor
Motiva USA LLC
Industry
Eligibility
22 Years and older · Female only
Enrollment
2,400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2037
U.S. locations
33
States / cities
Beverly Hills, California • Camp Pendleton, California • Los Gatos, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 5, 2026, 9:04 AM EDT
Completed Phase 1 Interventional

Treatment of Actinic Keratoses (AK) on the Face

NCT02411851
View directory record Official record
Conditions
Actinic Keratoses
Interventions
ingenol mebutate 0.015%, dermasil lotion
Drug · Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Sep 5, 2026, 9:04 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

NATRELLE® 410 Full and Moderate Height/Projection Breast Implant Continued Access Post-Approval Study

NCT01853605
View directory record Official record
Conditions
Breast Augmentation, Breast Reconstruction, Breast Implant Revision
Interventions
Anatomically shaped silicone gel-filled breast implants
Device
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older · Female only
Enrollment
3,811 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2014
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 10, 2015 · Synced Sep 5, 2026, 9:04 AM EDT
Withdrawn Not applicable Interventional

StrataXRT for the Prevention and Treatment of Radiation Dermatitis in Breast Cancer or Head and Neck Cancer Patients

NCT05073172
View directory record Official record
Conditions
Breast Carcinoma, Head and Neck Carcinoma, Radiation-Induced Dermatitis
Interventions
Calendula Ointment, Petrolatum-Mineral Oil-Lanolin-Ceresin Ointment, Polyethylene Glycol Hydrogel, Silicone-based Film Forming Topical Gel, Silver Sulfadiazine, Topical Hydrocortisone
Drug · Other
Lead sponsor
OHSU Knight Cancer Institute
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 5, 2024 · Synced Sep 5, 2026, 9:04 AM EDT
Active, not recruiting Not applicable Interventional

Memory Gel and Shape Combined Cohort

NCT02919592
View directory record Official record
Conditions
Primary Breast Augmentation, Primary Breast Reconstruction, Revision Breast Augmentation, Revision Breast Reconstruction
Interventions
MemoryShape® Breast Implants, MemoryGel® Breast Implants, Other Aesthetic Surgery
Device · Procedure
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older · Female only
Enrollment
3,603 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2031
U.S. locations
78
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • Gilbert, Arizona + 64 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 5, 2026, 9:04 AM EDT
Completed Not applicable Interventional

"A Clinical Study Investigating the Effectiveness of OTC Scar-management Modalities"

NCT04169490
View directory record Official record
Conditions
Scar, Keloid, Hypertrophic Scar, Cicatrix
Interventions
Placebo Cream Base Emulsion Moisturizer, FS2 Emulsion Moisturizer, Active Comparator Onion Skin Extract Gel (Mederma), Active Comparator Silicone Gel (Kelo-Cote), Active Comparator Silicone Gel (Kelo-Cote) + FS2 Emulsion Moisturizer
Other
Lead sponsor
The Center for Clinical and Cosmetic Research
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated Mar 20, 2022 · Synced Sep 5, 2026, 9:04 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars

NCT00754247
View directory record Official record
Conditions
Keloid, Hypertrophic Scar, Cicatrix, Hypertrophic
Interventions
0.5% hydrocortisone, silicone, vitamin E lotion, Onion extract gel, Cetearyl alcohol lotion
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 9, 2019 · Synced Sep 5, 2026, 9:04 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Postcoital Testing Study of the SILCS Diaphragm Used With 3% N-9 Gel, ContraGel, or No Gel

NCT02309554
View directory record Official record
Conditions
Contraception
Interventions
SILCS diaphragm used with ContraGel, SILCS diaphragm used with 3% Nonoxynol-9, SILCS diaphragm
Other
Lead sponsor
CONRAD
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 31, 2016 · Synced Sep 5, 2026, 9:04 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Study of the Safety and Effectiveness of Motiva Implants®

NCT03579901
View directory record Official record
Conditions
Breast Implants
Interventions
Silicone gel-filled breast implants - Motiva Implants® Investigational breast implants
Device
Lead sponsor
Motiva USA LLC
Industry
Eligibility
18 Years to 70 Years · Female only
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2033
U.S. locations
27
States / cities
Beverly Hills, California • Santa Monica, California • Westlake Village, California + 20 more
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 5, 2026, 9:04 AM EDT
Withdrawn Phase 3 Interventional

Spectra Breast Implant Study

NCT00981266
View directory record Official record
Conditions
Augmentation, Augmentation Revision, General Breast Enlargement, Post-lactational Involution, Asymmetry
Interventions
Mentor Spectra/Becker 80 Breast Implant
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
22 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2026
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Feb 28, 2013 · Synced Sep 5, 2026, 9:04 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Hypertrophic Scar Prevention by Novel Topical Gel Application

NCT03403621
View directory record Official record
Conditions
Hypertrophic Scar
Interventions
Pentamidine Isethionate, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Sep 5, 2026, 9:04 AM EDT
Terminated Phase 4 Interventional Results available

Becker Continued Access Study

NCT01286870
View directory record Official record
Conditions
Breast Reconstruction
Interventions
Mentor Becker 25 Expander/Breast Implant, Mentor Becker 50 Expander/Breast Implant
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older · Female only
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced Sep 5, 2026, 9:04 AM EDT
Completed Phase 3 Interventional Results available

Mentor Siltex® Contour Profile Gel Mammary Prosthesis Clinical Trial

NCT00812097
View directory record Official record
Conditions
Breast Augmentation, Breast Reconstruction, Breast Revision
Interventions
Mentor Siltex® Contour Profile Gel Mammary Prosthesis
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older · Female only
Enrollment
955 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2014
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2016 · Synced Sep 5, 2026, 9:04 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Post Market Clinical Experience Study of Sientra 207 Breast Implants

NCT02905617
View directory record Official record
Conditions
Breast Augmentation, Breast Revision-Augmentation
Interventions
Sientra 207 Silicone Gel Breast Implant
Device
Lead sponsor
Tiger Biosciences, LLC.
Industry
Eligibility
22 Years and older · Female only
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 5, 2026, 9:04 AM EDT
Active, not recruiting Not applicable Interventional

A Study of the Safety and Effectiveness of the Mentor Larger Size MemoryGel Ultra High Profile Breast Implants in Subjects Who Are Undergoing Primary Breast Reconstruction or Revision Reconstruction

NCT02724371
View directory record Official record
Conditions
Breast Reconstruction, Revision Breast Reconstruction
Interventions
Mentor Larger Size MemoryGel Ultra High Profile Breast Implant
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older · Female only
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2029
U.S. locations
30
States / cities
Montgomery, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 25 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 5, 2026, 9:04 AM EDT
Completed Not applicable Interventional Results available

Sientra Sponsored Silimed Gel-Filled Breast Implant Core Clinical Study

NCT00905645
View directory record Official record
Conditions
Breast Augmentation, Breast Reconstruction, Breast Revision
Interventions
Silimed Gel-Filled Mammary Implant
Device
Lead sponsor
Tiger Biosciences, LLC.
Industry
Eligibility
18 Years and older · Female only
Enrollment
1,788 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2018
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Jan 10, 2024 · Synced Sep 5, 2026, 9:04 AM EDT
Completed No phase listed Observational

Retrospective Cohort Study Comparing a Novel Gel Dressing vs SoC in the Treatment of Radiation Dermatitis

NCT05810194
View directory record Official record
Conditions
Radiation Dermatitis
Interventions
StrataXRT, Calendula, Aquaphor
Device · Drug
Lead sponsor
Stratpharma AG
Industry
Eligibility
18 Years and older
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Sep 5, 2026, 9:04 AM EDT