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Showing 1–24 of 225 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: smoking abstinence Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior

NCT03840694
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Withdrawal
Interventions
Smoking Abstinence, Ad Lib Smoking
Other
Lead sponsor
Duke University
Other
Eligibility
21 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls

NCT01214005
View directory record Official record
Conditions
Tobacco Use Disorder, Schizophrenia
Interventions
smoking abstinence
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 26, 2012 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobile Sensing of Smoking Behavior

NCT02116283
View directory record Official record
Conditions
Smoking, Health
Interventions
48 hour smoking abstinence, Smartphone
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 4, 2014 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders

NCT06554873
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, NJOY e-cigarette, on!
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Spanish-Language Smoking Cessation Trial

NCT02945787
View directory record Official record
Conditions
Smoking Cessation
Interventions
Spanish-Language Version of the Stop Smoking for Good, NCI-Produced Spanish-language Self-help Booklet
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
1,417 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 3, 2022 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes

NCT05383508
View directory record Official record
Conditions
Nicotine Vaping, Nicotine, Vaping
Interventions
CA35, CM35, Cig
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
24 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Phase 3 Interventional Results available

Smoking Cessation With the Nicotine Patch: A Pilot Study of Patch Messaging

NCT01287377
View directory record Official record
Conditions
Smoking Cessation
Interventions
Telephone Counseling, Nicotine Patches
Behavioral · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized Trial of Internet Access to Nicotine Patches

NCT00534404
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Nicotine patches, Telephone counseling, iQuit Smoking website
Drug · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
2,485 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 2, 2015 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Phase 4 Interventional Results available

Engagement With an Adaptive Mobile Health Smoking Cessation Intervention

NCT04020718
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Brief telephone advice plus tailored text messages, Mailed nicotine replacement therapy, Proactive telephone coaching
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Phase 2 Interventional Results available

Effect of Ramelteon on Smoking Abstinence

NCT02560324
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2019 · Synced Sep 11, 2026, 3:56 PM EDT
Recruiting Not applicable Interventional

Family-Based Financial Incentives Intervention for Smoking Cessation

NCT06556433
View directory record Official record
Conditions
Smoking Cessation
Interventions
Financial Incentive Rewards
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
1,312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

THC Crossover Study

NCT04429568
View directory record Official record
Conditions
THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions
Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional

Web and Phone Intervention to Maintain Postpartum Tobacco Abstinence

NCT01864954
View directory record Official record
Conditions
Smoking
Interventions
Web+phone
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Results available

Financial Incentives for Smoking Cessation Among Disadvantaged Pregnant Women

NCT02210832
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Best practices, financial incentives
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older · Female only
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Motivation and Skills for Detained Teen Smokers

NCT01387516
View directory record Official record
Conditions
Motivational Intervention, Nicotine Anonymous, Cognitive Behavior Therapy, Relaxation Therapy
Interventions
Motivational Intervention, Relaxation Therapy, Cognitive Behavioral Therapy, Self-Help Programming
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
13 Years to 19 Years
Enrollment
314 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Cranston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effects of Chantix on Relapse Prevention for Smoking Cessation

NCT00948649
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Placebo, Varenicline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 16, 2010 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Varenicline and Combined NRT for Smoking Cessation

NCT02271919
View directory record Official record
Conditions
Cigarette Smoker, Tobacco Use Disorder
Interventions
Nicotine Lozenge, Nicotine Patch, Placebo, Tobacco Cessation Counseling, Varenicline
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
631 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Results available

Contingency Management for Smoking in Substance Abusers

NCT00807742
View directory record Official record
Conditions
Substance Abuse
Interventions
Nicotine Replacement Treatment (NRT), Brief Advice, Contingency Management, Non-Contingent Reinforcement
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Rimonabant as an Aid to Maintenance of Smoking Cessation

NCT00459173
View directory record Official record
Conditions
Maintenance of Smoking Cessation
Interventions
rimonabant (SR141716)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
4,850 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 6, 2009 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Varenicline on Brain Activity During Nicotine Abstinence

NCT00602927
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2011 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Inspired: Smartphone Videogame-Based Smoking Cessation Intervention

NCT03929003
View directory record Official record
Conditions
Smoking Cessation
Interventions
Inspired
Behavioral
Lead sponsor
Rowan University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Glassboro, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional

Quit IT: Development of a Web-based, 3D Coping Skills Game to Increase Self-Efficacy for Maintaining Smoking Abstinence Following Hospitalization

NCT01915836
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
web-based video game (Quit IT), Questionnaires, Evaluation Interview
Other · Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
30 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 10, 2014 · Synced Sep 11, 2026, 3:56 PM EDT
Completed Not applicable Interventional

Ethnic Microaggressions and Smoking Behaviors Among Latinx Adults

NCT05490927
View directory record Official record
Conditions
Smoking, Discrimination, Racial
Interventions
Microaggression Recall and Relapse Analogue Task
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 11, 2026, 3:56 PM EDT
Completed No phase listed Observational

Physiological, Cognitive and Cerebral Activity Changes as a Function of Cigarette Smoking (With or Without Nicotine) and Tobacco Abstinence

NCT01034384
View directory record Official record
Conditions
Smoking Cessation
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 11, 2026, 3:56 PM EDT