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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: standard nicotine content cigarettes Clear all
Completed Phase 2 Interventional Accepts healthy volunteers

Maintaining Abstinence in Chronic Cigarette Smokers - 1

NCT00087880
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion and NRT
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
407 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Phase 2 Interventional

Very Low Nicotine Cigarettes in Smokers With Schizophrenia

NCT02019459
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Very low nicotine content cigarettes, standard nicotine content cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 70 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 8, 2018 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Phase 4 Interventional

Smartphone-delivered Automated Video-assisted Smoking Treatment for Patrons of a Food Resource Center

NCT03060278
View directory record Official record
Conditions
Smoking Cessation
Interventions
Self-help materials, nicotine patch, Smartphone-delivered automated treatment, Counseling
Behavioral · Drug · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 99 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 11, 2018 · Synced Sep 21, 2026, 11:50 AM EDT
Recruiting Not applicable Interventional

Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing

NCT07161050
View directory record Official record
Conditions
Cigarette Smoking, E-cigarette Use
Interventions
Nicotine Content, Illegal cigarette price, E-cigarette price
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation

NCT02927847
View directory record Official record
Conditions
Smoking
Interventions
Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (.03 mg), Behavioral Activation, Supportive Counseling
Drug · Behavioral
Lead sponsor
Maggie M Sweitzer, PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Not applicable Interventional

Mobile Contingency Management for Smoking Cessation in Returning US Veterans

NCT02513069
View directory record Official record
Conditions
Smoking, Veterans
Interventions
Nicotine gum, mobile contingency management, Telephone counseling, Nicotine patch, Nicotine lozenge, Smart phone, Carbon monoxide monitor
Other · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Not applicable Interventional

Cigarette Packaging of Low Nicotine Cigarettes

NCT03802019
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
LNC Cigarettes + Colored Packaging, Own Brand
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years to 65 Years
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Not applicable Interventional

Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes

NCT01681875
View directory record Official record
Conditions
Tobacco Dependence
Interventions
very low nicotine content cigarettes
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
839 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
9
States / cities
San Francisco, California • Tampa, Florida • Baltimore, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Phase 4 Interventional Results available

Health Systems Reach Interventions Project

NCT04199117
View directory record Official record
Conditions
Smoking, Cigarette, Smoking Cessation
Interventions
Varenicline, Combination nicotine patch and nicotine mini-lozenge treatment, Monetary incentives for initiating treatment, Automated tailored outreach, Care management, Wisconsin Tobacco Quit Line referral, Primary care provider referral, Untailored outreach, Multiple smoking cessation coaching calls
Drug · Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Not applicable Interventional

Smartphone-delivered Automated Video-assisted Smoking Treatment for People Living With HIV

NCT03082482
View directory record Official record
Conditions
Smoking Cessation
Interventions
Self-help materials, nicotine patch, Counseling, Smartphone-delivered automated treatment
Behavioral · Drug · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 99 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 10, 2018 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers

NCT01633567
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Culturally Targeted Cessation Program, Non-Targeted Cessation Program
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Sep 21, 2026, 11:50 AM EDT
Completed Not applicable Interventional

Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers

NCT02587312
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Very low nicotine content cigarettes, Standard nicotine content cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
15 Years to 19 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 26, 2022 · Synced Sep 21, 2026, 11:50 AM EDT
Recruiting Phase 2 Interventional

Enhancing Smoking Cessation for African American People Everywhere

NCT07024992
View directory record Official record
Conditions
ESCAPE Intervention+NRT, quitSTART Intervention+NRT, CTRL+NRT
Interventions
ESCAPE app + NRT, quiSTART app + NRT, Control (CTRL)
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 21, 2026, 11:50 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

NCT06395415
View directory record Official record
Conditions
Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
Interventions
EQUIP, Standard Care
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 26 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 21, 2026, 11:50 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents

NCT07460622
View directory record Official record
Conditions
E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
Interventions
Virtual Reality E-Cigarette Prevention Program
Behavioral
Lead sponsor
Yale University
Other
Eligibility
11 Years to 15 Years
Enrollment
1,251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 21, 2026, 11:50 AM EDT