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Showing 1–24 of 63 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: standard opioid prescribing Clear all
Suspended Phase 4 Interventional

Opioid Reduction Toolkit Reduces Opioids Prescribed and Consumed

NCT05363436
View directory record Official record
Conditions
Opioid Abuse, Opioid Misuse, Pain
Interventions
Oxycodone
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 99 Years
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 21, 2024 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Toward Zero Prescribed Opioids for Outpatient General Surgery

NCT05327777
View directory record Official record
Conditions
Opioid Misuse and Addiction, Pain
Interventions
Oxycodone, Zero Opioid Protocol
Drug · Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 99 Years
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 4, 2023 · Synced Sep 24, 2026, 8:14 AM EDT
Active, not recruiting Not applicable Interventional

CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs

NCT06565546
View directory record Official record
Conditions
Ventral Hernia
Interventions
Opioid pain medication prescribed based on CYP2D6 genotype testing PLUS Acetaminophen and Gabapentin, Acetaminophen and Gabapentin: standard postoperative pain medications
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional

Post-market, Randomized, Controlled, Prospective Study Evaluating Intrathecal Pain Medication (IT) Versus Conventional Medical Management (CMM) in the Non-cancer, Refractory, Chronic Pain Population

NCT04096391
View directory record Official record
Conditions
Chronic Nonmalignant Pain, Pain, Intractable, Pain, Chronic
Interventions
Flowonix Prometra® II Programmable Infusion System, Pain Medicine
Device · Drug
Lead sponsor
Evolve Restorative Center
Other
Eligibility
22 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Santa Rosa, California
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced Sep 24, 2026, 8:14 AM EDT
Recruiting Not applicable Interventional

Integrated Treatment for Opioid Use Disorder and PTSD

NCT06641115
View directory record Official record
Conditions
Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions
HOPE Therapy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 27, 2025 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional

Postoperative Pain Management Following Robotic Assisted Sacrocolpopexy

NCT06309693
View directory record Official record
Conditions
Pelvic Organ Prolapse, Post Operative Pain
Interventions
Quadratus Lumborum (QL) Block, Enhanced Recovery After Surgical (ERAS) Protocol
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 24, 2026, 8:14 AM EDT
Terminated Not applicable Interventional Results available

Intrathecal Morphine Compared to Conventional Medical Management for Pain Control and Opioid-related Side Effects

NCT01924182
View directory record Official record
Conditions
Chronic Pain
Interventions
SynchroMed Infusion System and Intrathecal Morphine Sulfate, Conventional Medicine
Device · Other
Lead sponsor
MedtronicNeuro
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
6
States / cities
Homewood, Alabama • Napa, California • Walnut Creek, California + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2018 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transforming Opioid Prescribing in Primary Care

NCT01909076
View directory record Official record
Conditions
Chronic Pain, Opioid-Related Disorders
Interventions
Electronic decision support tools, Enhanced patient education materials, Nurse care management, Electronic Patient Registry, Academic detailing
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2016 · Synced Sep 24, 2026, 8:14 AM EDT
Terminated Phase 4 Interventional Results available

Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery

NCT04990804
View directory record Official record
Conditions
Opioid Use, Spinal Diseases, Surgery--Complications, Surgery, Postoperative Pain
Interventions
Opioid Analgesic, Opioid-Free Postoperative Pain Regimen
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 30, 2024 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Phase 1 Interventional

The Effect Of An Anesthetic Procedure On Post Operative Pain Management In Carpal Tunnel Release

NCT03729375
View directory record Official record
Conditions
Pain, Postoperative, Carpal Tunnel Syndrome
Interventions
10cc injection of bupivacaine, 20cc injection of bupivacaine
Drug
Lead sponsor
University of South Florida
Other
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 17, 2020 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional Results available

Strategies to Improve Pain and Enjoy Life

NCT03743402
View directory record Official record
Conditions
Chronic Pain
Interventions
Pain self-management training, video education, motivational interviewing, voluntary self-paced opioid taper, prescribing guidance for primary care provider, usual care
Behavioral · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Sep 24, 2026, 8:14 AM EDT
Not yet recruiting Phase 4 Interventional

Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery

NCT07796152
View directory record Official record
Conditions
Knee Arthroplasty, Total, Post Operative Pain, Acute, Opioid Consumption, Postoperative
Interventions
Suzetrigine, Opioid standard care pain medicine
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Patient-Directed Postoperative Opioid Prescribing for Gynecologic Surgery

NCT03805386
View directory record Official record
Conditions
Gynecology, Surgery, Opioid Use
Interventions
Physician directed opioid prescribing, Patient directed opioid prescribing
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Sep 24, 2026, 8:14 AM EDT
Not yet recruiting Not applicable Interventional

Integrating MOUD in Nonmedical Community Settings (Better Together)

NCT06416020
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
HC-MOUD Only, BT-MOUD with Buprenorphine
Behavioral
Lead sponsor
Howard University
Other
Eligibility
16 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Washington D.C., District of Columbia • Miami, Florida • Chicago, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact on Opioid Use of Bundling Medication-assisted Treatment With mHealth

NCT02712034
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
MAT + A-CHESS, MAT
Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
417 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 13, 2020 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional

Targeting Effective Analgesia in Clinics for HIV - Intervention

NCT02564341
View directory record Official record
Conditions
HIV Infection, Pain, Drug Dependence
Interventions
Collaboration with an IT enabled nurse care manager, Education and academic detailing, Facilitated access to a specialist in addictions
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
Atlanta, Georgia • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Sep 24, 2026, 8:14 AM EDT
Terminated Phase 2 Interventional

Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid

NCT04291599
View directory record Official record
Conditions
Acute Pancreatitis
Interventions
Ketorolac, Opioid
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 21 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Novel Multimodal Pain Control Protocol for Minimally Invasive Gynecologic Surgery

NCT04710277
View directory record Official record
Conditions
Postoperative Pain, Narcotic Use, Cryotherapy Effect
Interventions
Opioid-sparing multimodal pain management, Usual care
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 11, 2023 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Discharge Opioid Education to Decrease Opioid Use After Cesarean

NCT03678870
View directory record Official record
Conditions
Opioid Use
Interventions
Opioid Education Handout
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
196 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 16, 2020 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Phase 2 Interventional

Emergency Department-Initiated Buprenorphine Validation Network Trial

NCT04225598
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
CAM2038, Buprenorphine Sublingual Product
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
35
States / cities
Oakland, California • San Leandro, California • New Haven, Connecticut + 25 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Sep 24, 2026, 8:14 AM EDT
Enrolling by invitation Phase 4 Interventional Accepts healthy volunteers

Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity

NCT07750639
View directory record Official record
Conditions
Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
Interventions
Naproxen, Acetaminophen, oxycodone, Gabapentin
Drug
Lead sponsor
AdventHealth
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional

Prescribing Opioid Pain Relievers in the Emergency Department: Understanding and Optimizing the Encounter

NCT02299024
View directory record Official record
Conditions
Opioid Use, Unspecified
Interventions
Additional Opioid Information
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Sep 24, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Postoperative Opt-In Narcotic Treatment Study

NCT04710069
View directory record Official record
Conditions
Postoperative Pain, Narcotic Use, Analgesia, Endocrine Surgery, Opioid Use, Opioid Abuse
Interventions
POINT
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Sep 24, 2026, 8:14 AM EDT
Enrolling by invitation Not applicable Interventional

Alternatives to Dental Opioid Prescribing After Tooth Extraction

NCT06275191
View directory record Official record
Conditions
Analgesics, Opioid, Acute Pain, Tooth Extraction, Adolescent, Acetaminophen, Ibuprofen
Interventions
Multicomponent intervention, Usual care
Behavioral · Other
Lead sponsor
Douglas Oyler
Other
Eligibility
12 Years to 25 Years
Enrollment
38,159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 24, 2026, 8:14 AM EDT