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ClinicalTrials.gov public records Last synced Oct 18, 2026, 7:06 AM EDT

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Showing 25–48 of 73 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: sucralose Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Role of Altered Nutrient Partitioning in Food Reward

NCT05200845
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose, Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose, High-Fat Test Meal Inside a Metabolic Chamber, High-Carbohydrate Test Meal Inside a Metabolic Chamber, fMRI Scan
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Phase 4 Interventional Results available

rHGH and Intestinal Permeability in Intestinal Failure

NCT01380366
View directory record Official record
Conditions
Short Bowel Syndrome
Interventions
Somatropin, Seven Day Food Diary, Blood Tests (standard of care), Fasting, Sugar Permeability Test, Urine Collection
Drug · Procedure · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 8, 2016 · Synced Oct 18, 2026, 7:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluating the Brain's Response to Natural Versus Artificial Sweetener in Women Who Have Had an Eating Disorder

NCT00517335
View directory record Official record
Conditions
Eating Disorders
Interventions
Functional magnetic resonance imaging (fMRI) scan
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2016 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Preoperative Carbohydrate Rich Drinks on Immediate Postoperative Outcome in Total Knee Arthroplasty

NCT03380754
View directory record Official record
Conditions
Post Operative Nausea and Vomiting
Interventions
Nutricia preOp, Nestle Splash Lemon Flavor Water (Placebo)
Dietary Supplement · Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Phase 2 Interventional Results available

Trial to Investigate the Safety and Efficacy of Cannabidiol Oral Solution (GWP42003-P; CBD-OS) in Children and Adolescents With Autism Spectrum Disorder

NCT04745026
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
GWP42003-P, Placebo
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
6 Years to 17 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
12
States / cities
Phoenix, Arizona • La Jolla, California • Los Angeles, California + 9 more
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 18, 2026, 7:06 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Effect of Blueberries on Enhancing Insulin Sensitivity in Humans: A Pilot Study

NCT01005420
View directory record Official record
Conditions
Insulin Sensitivity
Interventions
Blueberry Powder, Placebo
Dietary Supplement
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
20 Years to 99 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity and Preference - Pilot

NCT02335008
View directory record Official record
Conditions
Impairment of Oral Perception
Interventions
Sucralose, Sucrose
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 15, 2015 · Synced Oct 18, 2026, 7:06 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers

NCT04333745
View directory record Official record
Conditions
Kidney Stone
Interventions
Controlled Diet, Carbon-13 Oxalate and Sucralose Ingestion
Other · Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sucralose and Lactisole Additions to OGTT in Humans

NCT05900193
View directory record Official record
Conditions
Neat OGTT, OGTT With Added Sucralose, OGTT With Added Lactisole
Interventions
TAS1R2/3 agonist or antagoinst admixture to oral glucose tolerance test
Dietary Supplement
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 70 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Phase 3 Interventional Results available

Naturlose (D-Tagatose) Efficacy Evaluation Trial

NCT00955747
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Tagatose, Sugar Substitute Splenda
Drug
Lead sponsor
Robert Lodder
Industry
Eligibility
18 Years to 75 Years
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
21
States / cities
Hueytown, Alabama • Huntsville, Alabama • Jonesboro, Arkansas + 18 more
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Oct 18, 2026, 7:06 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Cephalic Phase Responses to Nutritive and Non-Nutritive Sweeteners

NCT06387316
View directory record Official record
Conditions
Pre Diabetes
Interventions
No Oral Stimulation, Oral water stimulation, Oral Salt Stimulation, Oral Sucralose Stimulation, Oral Sucrose stimulation
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Phase 3 Interventional Results available

A Study of the Efficacy and Safety of JZP-258 in Subjects With Narcolepsy With Cataplexy

NCT03030599
View directory record Official record
Conditions
Narcolepsy With Cataplexy
Interventions
JZP-258, Placebo
Drug · Other
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years to 70 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
12
States / cities
Orange, California • Stanford, California • Boulder, Colorado + 9 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Metabolomic Impacts of Branched-chain Amino Acid Supplementation During Endurance Exercise

NCT04969536
View directory record Official record
Conditions
Healthy
Interventions
Branched Chain Amino Acids, Placebo
Dietary Supplement · Other
Lead sponsor
Montana State University
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated May 3, 2023 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Phase 3 Interventional Results available

Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms (GWPCARE7)

NCT02953548
View directory record Official record
Conditions
Infantile Spasms
Interventions
GWP42003-P
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
1 Month to 24 Months
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
6
States / cities
Little Rock, Arkansas • Winston-Salem, North Carolina • Columbus, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2022 · Synced Oct 18, 2026, 7:06 AM EDT
Terminated Phase 2 Interventional Results available

Trial to Investigate the Safety and Efficacy of GWP42003-P Versus Placebo as Adjunctive Therapy in Participants With Schizophrenia Experiencing Inadequate Response to Ongoing Antipsychotic Treatment

NCT04421456
View directory record Official record
Conditions
Schizophrenia
Interventions
GWP42003-P, Placebo
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years to 55 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
19
States / cities
Bentonville, Arkansas • Little Rock, Arkansas • Garden Grove, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2023 · Synced Oct 18, 2026, 7:06 AM EDT
Recruiting Phase 2Phase 3 Interventional

Study of Cannabidiol in Sanfilippo Syndrome

NCT06333041
View directory record Official record
Conditions
Sanfilippo Syndrome, Mucopolysaccharidosis III
Interventions
Epidiolex, Placebo
Drug
Lead sponsor
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Other
Eligibility
4 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Health Effects of Substituting Sugary Beverages With Artificially-sweetened Beverages or Water

NCT04567108
View directory record Official record
Conditions
Body Weight
Interventions
Maintain usual SSBs, Substitute to non-SSBs, Study app, Beverage delivery
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
20 Years to 69 Years
Enrollment
461 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Phase 1 Interventional Results available

University of Alabama at Birmingham (UAB) Adult CBD Program

NCT02700412
View directory record Official record
Conditions
Epilepsy, Seizures
Interventions
Epidiolex
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 99 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 8, 2020 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sugar-replacement Sweeteners, and Blood Sugar Control

NCT01128829
View directory record Official record
Conditions
Obesity
Interventions
Water, Sucralose
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
21 Years to 40 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 22, 2014 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sucralose, Stevia, Gut Microbiome and Glucose Metabolism

NCT02800707
View directory record Official record
Conditions
Impaired Glucose Tolerance
Interventions
Sucralose, Stevia
Other
Lead sponsor
University of Minnesota
Other
Eligibility
35 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 22, 2018 · Synced Oct 18, 2026, 7:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-nutritive Sweeteners in Inflammatory Bowel Disease

NCT07769437
View directory record Official record
Conditions
Inflamatory Bowel Disease, Crohn Disease (CD)
Interventions
Sucralose (non-nutritive sweetener)
Other
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
3
States / cities
Chagrin Falls, Ohio • Cleveland, Ohio • Westlake, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Phase 2 Interventional

A Pilot Trial to Determine the Efficacy of Lactobacillus Rhamnosus for Reducing Colonization by Methicillin-resistant Staphylococcus Aureus (MRSA) (PROSE)

NCT01112995
View directory record Official record
Conditions
Infection
Interventions
Lactobacillus rhamnosus, Sugar pill (placebo)
Dietary Supplement
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 5, 2015 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Phase 3 Interventional Results available

Antiepileptic Efficacy Study of GWP42003-P in Children and Young Adults With Dravet Syndrome (GWPCARE1)

NCT02091375
View directory record Official record
Conditions
Epilepsy, Dravet Syndrome
Interventions
GWP42003-P 20 mg/kg/day Dose, Placebo control
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
2 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
13
States / cities
Miami, Florida • Orlando, Florida • Atlanta, Georgia + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 18, 2026, 7:06 AM EDT
Completed Phase 2 Interventional Results available

A Dose-ranging Pharmacokinetics and Safety Study of GWP42003-P in Children With Dravet Syndrome (GWPCARE1)

NCT02091206
View directory record Official record
Conditions
Epilepsy, Dravet Syndrome
Interventions
GWP42003-P 5 mg/kg/day Dose, Placebo control, GWP42003-P 10 mg/kg/day Dose, GWP42003-P 20 mg/kg/day Dose
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
4 Years to 10 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
8
States / cities
Miami, Florida • Atlanta, Georgia • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 18, 2026, 7:06 AM EDT