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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: tACS Clear all
Completed Not applicable Interventional Results available

Non-Invasive Brain Stimulation and Substance Use

NCT03122587
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Transcranial Alternating Current Stimulation at 10 Hz, Transcranial Alternating Current Stimulation at 40 Hz, Active sham transcranial alternating current stimulation
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 55 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2020 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of Transcranial Direct Current Stimulation (tDCS) Coupled With Constraint Induced Movement Therapy in Stroke Patient

NCT01143649
View directory record Official record
Conditions
Stroke, Healthy
Interventions
transcranial direct current stimulation (tDCS), constraint induced movement therapy (CIMT), transcranial alternating current stimulation (tACS)
Device · Procedure
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Results available

Transcranial Current Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia

NCT01963676
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Auditory Hallucinations
Interventions
tDCS, Sham stimulation
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 21, 2016 · Synced Sep 4, 2026, 9:54 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

HALO Clarity™ Cranial Alternating Current Stimulation Therapy for Adults With Moderate-to-Severe Insomnia

NCT07659366
View directory record Official record
Conditions
Moderate to Severe Insomnia
Interventions
Transcranial alternating current stimulator
Device
Lead sponsor
Nexalin Technology
Industry
Eligibility
22 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Phase 2 Interventional Results available

Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip

NCT03382262
View directory record Official record
Conditions
Osteoarthritis of the Shoulder, Osteoarthritis of the Hip
Interventions
FX006 32 mg, TAcs 40 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
6
States / cities
El Cajon, California • La Mesa, California • San Diego, California + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Sep 4, 2026, 9:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Memory Enhancement in Aging With Optimal Dosing

NCT07461584
View directory record Official record
Conditions
Aging, Noninvasive Brain Stimulation, Memory
Interventions
1-day patterned tACS, 3-day patterned tACS, 5-day patterned tACS, 1-day continuous tACS, 3-day continuous tACS, 5-day continuous tACS
Device
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
65 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 4, 2026, 9:54 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Stimulating After Recovery From Traumatic Brain Injury

NCT05327829
View directory record Official record
Conditions
TBI (Traumatic Brain Injury)
Interventions
External non-invasive stimulation, COGED
Combination Product · Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Phase 2 Interventional Results available

Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA

NCT03378076
View directory record Official record
Conditions
Bilateral Knee Osteoarthritis
Interventions
FX006 32 mg, TAcs 40 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
3
States / cities
Torrance, California • Rochester, New York • Duncansville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

At-home Transcranial Alternating Current Stimulation During Multitasking

NCT04231825
View directory record Official record
Conditions
Multitasking Behavior
Interventions
Transcranial alternating current stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 35 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2022 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Phase 2 Interventional Results available

Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee

NCT02637323
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
FX006 32 mg, TCA IR 40
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
4
States / cities
Canoga Park, California • San Diego, California • Hialeah, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Sep 4, 2026, 9:54 PM EDT
Recruiting Phase 2 Interventional

Modulation Effect of tACS on Chronic Low Back Pain

NCT06568198
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Real tACS, Sham tACS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 4, 2026, 9:54 PM EDT
Recruiting Not applicable Interventional

tACS for Neuropathic Pain Management After SCI

NCT06029075
View directory record Official record
Conditions
Neuropathic Pain Management
Interventions
tACS Sham, tACS 10Hz, tACS 20Hz
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 4, 2026, 9:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Restorative Neurophysiology: Backing up and Restoring the Brain (BandR)

NCT07252011
View directory record Official record
Conditions
Adults With Variability in Their Mood
Interventions
Transcranial alternating current stimulation (tACS), Neuro/biofeedback, Recall, Physiological stimulation
Device · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 4, 2026, 9:54 PM EDT
Terminated Phase 2 Interventional Results available

Proof of Concept Study Comparing FX006 to Kenalog®-40 in Patients With Post-Traumatic Osteoarthritis of the Knee

NCT02468583
View directory record Official record
Conditions
Post-traumatic Osteoarthritis of the Knee
Interventions
FX006 32 mg, TCA IR 40 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
20 Years to 50 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Phase 3 Interventional Results available

Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee

NCT02357459
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
FX006, Placebo, TCA IR 40
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
486 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
22
States / cities
Phoenix, Arizona • Tucson, Arizona • Anaheim, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Results available

Transcranial Alternating Current Stimulation for Major Depressive Disorder

NCT02339285
View directory record Official record
Conditions
Major Depressive Disorder, MDD
Interventions
tACS (alpha), tACS (gamma)
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 19, 2018 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Results available

Mechanism of Action of tACS for the Treatment of MDD

NCT03994081
View directory record Official record
Conditions
Major Depressive Disorder, MDD
Interventions
tACS, Sham tACS
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Results available

Augmenting Single-session Behavioral Activation (BA) With Delta-beta Transcranial Alternating Current Stimulation (tACS) for the Treatment of Depression

NCT05693922
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Delta-beta cross-frequency transcranial alternating current stimulation via the NeuroConn DC-STIMULATOR MC, Single-session behavioral activation, Active sham cross-frequency transcranial alternating current stimulation via the NeuroConn DC-STIMULATOR MC
Device · Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional

Frontoparietal Synchronization to Modulate Drug Craving in Opioid Use Disorder

NCT03907644
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Transcranial Alternating Current Stimulation (tACS)
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 61 Years · Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Single Session of tACS in a Depressive Episode

NCT03449979
View directory record Official record
Conditions
Depression, Major Depressive Disorder, Premenstrual Dysphoric Disorder, Depressive Episode
Interventions
XCSITE100 Stimulator Sham, XCSITE100 Stimulator tACS
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2020 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of tACS Stimulation on Alpha Oscillations

NCT03178344
View directory record Official record
Conditions
Healthy
Interventions
XCSITE100 Stimulator tACS, XCSITE100 Stimulator Sham
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 25, 2019 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Results available

Targeting Auditory Hallucinations With Alternating Current Stimulation

NCT03221270
View directory record Official record
Conditions
Schizophrenia, Schizo Affective Disorder
Interventions
tACS treatment week, tACS sham week, Maintenance tACS, Maintenance Sham tACS
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Results available

STimulation to Improve Auditory haLLucinations

NCT02360228
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
tACS (alpha), tDCS
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2018 · Synced Sep 4, 2026, 9:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Home-based Brain Stimulation for Memory

NCT04783350
View directory record Official record
Conditions
Alzheimer Disease, Memory Loss
Interventions
Transcranial alternating current stimulation (tACS)
Device
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
55 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Sep 4, 2026, 9:54 PM EDT