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ClinicalTrials.gov public records Last synced Oct 19, 2026, 12:30 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: tFUS Clear all

Conditions: Impulsive Behavior
Interventions: tFUS, Sham tFUS; Device
Lead sponsor: Mary Phillips, MD MD (Cantab); Other
Eligibility: 18 Years to 35 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Reaction Time, Alertness
Interventions: Transcranial Focused Ultrasound; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 22 Years to 55 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Essential Tremor
Interventions: Low Intensity Focused Ultrasound (LIFU); Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 90 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Mild Cognitive Impairment (MCI)
Interventions: Low intensity focused ultrasound, Sham (No Treatment); Device
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 55 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Healthy Volunteers, no Condition, Basic Science
Interventions: Transcranial Focused Ultrasound Stimulation, Electroencephalography, Magnetic Resonance Imaging; Device
Lead sponsor: Massachusetts Institute of Technology; Other
Eligibility: 21 Years to 55 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Bipolar
Interventions: BrainSonix Pulsar 1002; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Brain Imaging
Interventions: Feasibility of imaging using tFUS; Device
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Cranial Neurosurgery
Interventions: Brain imaging using transcranial focused ultrasound (tFUS); Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Sleep Disturbance, Stress, Psychological, REM Sleep Measurement
Interventions: NEUSleeP system (FUS-EEG wearable device), BrainSonix Pulsar 1002; Device
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 50 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Anxiety Disorders
Interventions: Active transcranial focused ultrasound (tFUS), Sham transcranial focused ultrasound (tFUS); Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Healthy
Interventions: Brainsonix Bx Pulsar machine tFUS; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Healthy
Interventions: transcranial focused ultrasound (tFUS); Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cocaine Use Disorder (CUD)
Interventions: tFUS, Sham tFUS; Device
Lead sponsor: Mary Phillips, MD MD (Cantab); Other
Eligibility: 18 Years to 45 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Healthy
Interventions: Transcranial Focused Ultrasound; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 22 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Parkinson Disease
Interventions: Gen0Bh Transcranial Focused Ultrasound System (Active), Gen0Bh Transcranial Focused Ultrasound System (Sham); Device
Lead sponsor: Sanmai Technologies PBC dba Sanmai; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 4
States / cities: Tucson, Arizona • Santa Monica, California • Gainesville, Florida + 1 more

Conditions: Impulsive Behavior
Interventions: tFUS, Sham tFUS; Device
Lead sponsor: Mary Phillips, MD MD (Cantab); Other
Eligibility: 18 Years to 45 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Healthy
Interventions: Focused Ultrasound Stimulation; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 55 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Mild Neurocognitive Disorder, Healthy Aging
Interventions: Transcranial Focused Ultrasound; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 50 Years to 85 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
Interventions: Low-Intensity Focused Ultrasound Pulsation (LIFUP); Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 50 Years to 90 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Interventions: The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 79 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 4
States / cities: Los Angeles, California • Pomona, California • Boston, Massachusetts + 1 more

Conditions: Healthy, Olfaction
Interventions: transcranial focused ultrasound (tFUS); Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Chronic Pain
Interventions: LIFU, Sham LIFU; Device
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Roanoke, Virginia

Search by objective public record fields.

Examining the Impact of Transcranial Focused Ultrasound (tFUS) on Reward Neural Circuitry

tFUS to Enhance Alertness and Performance

Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor

Mild Cognitive Impairment and Neuromodulation

Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans

Low-Intensity Focused Ultrasound of the Amygdala for Bipolar Disorder

tFUS Imaging & LIFU

Feasibility of Transcranial Focused Ultrasound to Measure Brain Tumor

Wearable Neural Interfacing System for REM Sleep Restoration and Enhancement

Modulating Escape Using Focused Ultrasound

tFUS Induced Transient Scotoma for Individual Dosing

Transcranial Focused Ultrasound (tFUS) Modulation of Reward Network

Examination of Transcranial Focused Ultrasound on Brain Activity in Adults With Cocaine Use Disorder

Safety Assessment of Central Medial Thalamus Stimulation Using Transcranial Focused Ultrasound

Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease

Examination of Transcranial Focused Ultrasound on Brain Activity in Adults

Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound

tFUS for Memory in mNCD and Healthy Adults

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

Ultrasound Stimulation for Patients in a Disorder of Consciousness

Olfactory Transcranial Focused Ultrasound

LIFU for Chronic Pain