- Conditions
- Complicated Parapneumonic Effusion, Empyema, Pleural
- Interventions
- Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.
- Drug
- Lead sponsor
- Dartmouth-Hitchcock Medical Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- Hanover, New Hampshire
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- Conditions
- Empyema
- Interventions
- tPA alone, tPA plus dornase
- Biological
- Lead sponsor
- Children's Mercy Hospital Kansas City
- Other
- Eligibility
- Up to 17 Years
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016
- U.S. locations
- 1
- States / cities
- Kansas City, Missouri
- Conditions
- Pleural Diseases
- Interventions
- Chest thoracoscopy, Chest fibrinolytic therapy, tPA, DNase
- Procedure · Drug
- Lead sponsor
- University of Florida
- Other
- Eligibility
- 18 Years to 90 Years
- Enrollment
- 5 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2020
- U.S. locations
- 1
- States / cities
- Gainesville, Florida