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ClinicalTrials.gov public records Last synced Oct 22, 2026, 5:13 PM EDT

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Showing 49–72 of 114 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: tonsillectomy Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

EXPAREL® for Pain After Tonsillectomy

NCT02444533
View directory record Official record
Conditions
Tonsillectomy, Tonsillitis, Post-operative Pain
Interventions
Liposomal Bupivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 14, 2017 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SZMN Blocks for Pain Control in Pediatric Patients Undergoing T&A

NCT04797559
View directory record Official record
Conditions
Postoperative Pain, Opioid Use
Interventions
SZMN Block
Procedure
Lead sponsor
Stanford University
Other
Eligibility
6 Months to 18 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 22, 2026, 5:13 PM EDT
Terminated No phase listed Observational

Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project)

NCT02095015
View directory record Official record
Conditions
Mucopolysaccharidosis (MPS)
Interventions
Not listed
Lead sponsor
Shire
Industry
Eligibility
Up to 7 Years · Male only
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
7
States / cities
Los Angeles, California • Jacksonville, Florida • Minneapolis, Minnesota + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2021 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Early Phase 1 Interventional

Closure Method Study Following Tonsillectomy in Children

NCT00730340
View directory record Official record
Conditions
Tonsillectomy, Children
Interventions
Closure of the Tonsillar Fossa, Tonsillectomy with open fossa
Procedure
Lead sponsor
University of Oklahoma
Other
Eligibility
5 Years to 10 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 15, 2010 · Synced Oct 22, 2026, 5:13 PM EDT
Not yet recruiting Phase 4 Interventional

Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management

NCT07821931
View directory record Official record
Conditions
Tonsillectomy, Pharyngoplasty, Suzetrigine, Opioid, Postoperative Pain, Acute Pain
Interventions
Suzetrigine, Acetaminophen, oxycodone
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 22, 2026, 5:13 PM EDT
Not listed Phase 4 Interventional

Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy

NCT00466544
View directory record Official record
Conditions
Obstructive Tonsillar Hypertrophy, Tonsillitis
Interventions
Plasmaknife, Monopolar
Device
Lead sponsor
Children's Hospital of Michigan
Other
Eligibility
4 Years to 16 Years
Enrollment
100 participants
Timeline
Started 2007
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 27, 2007 · Synced Oct 22, 2026, 5:13 PM EDT
Terminated Phase 4 Interventional Results available

Opioid & Steroid Use Following Tonsillectomy in Pediatric Patients

NCT04541147
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Dexamethasone, Analgesics
Drug
Lead sponsor
Duke University
Other
Eligibility
4 Years to 17 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Tonsillar Pillar Closure on Postoperative Pain and Bleeding Risk After Tonsillectomy

NCT00394849
View directory record Official record
Conditions
Hemorrhage, Pain
Interventions
suture one tonsillar fossa
Procedure
Lead sponsor
Indiana University
Other
Eligibility
Not listed
Enrollment
763 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2004
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 7, 2017 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pediatric Pain Optimization After Tonsillectomy

NCT05244226
View directory record Official record
Conditions
Obstructive Sleep Apnea, Tonsillitis, Pain, Procedural
Interventions
Fentanyl/Hydromorphone, Methadone
Drug
Lead sponsor
Duke University
Other
Eligibility
3 Years to 17 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Results available

Continuous Positive Airway Pressure (CPAP) After Adenotonsillectomy in Children

NCT01554527
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Child Behavior Disorders, Attention Deficit Disorder With Hyperactivity, Disorders of Excessive Somnolence
Interventions
CPAP treatment, No CPAP treatment
Procedure · Other
Lead sponsor
University of Michigan
Other
Eligibility
5 Years to 12 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 14, 2019 · Synced Oct 22, 2026, 5:13 PM EDT
Enrolling by invitation No phase listed Observational

Evaluating the Efficacy of Intravenous Acetaminophen (IV Tylenol) in Reducing Pain and Agitation in Pediatric Patients Undergoing Elective Tonsillectomy and/or Adenoidectomy

NCT07576985
View directory record Official record
Conditions
Tonsillectomy, Adenoidectomy
Interventions
No Intervention: Observational Cohort
Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
Up to 8 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Phase 4 Interventional

Dexamethasone and Post-tonsillectomy Pain in Children

NCT02793011
View directory record Official record
Conditions
Pediatric Post-tonsillectomy Pain
Interventions
Dexamethasone, Placebo
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
4 Years to 17 Years
Enrollment
137 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 10, 2020 · Synced Oct 22, 2026, 5:13 PM EDT
Enrolling by invitation No phase listed Observational

Fasting Time and Post-tonsillectomy Pain

NCT07574476
View directory record Official record
Conditions
Tonsillar Disorder
Interventions
Not listed
Lead sponsor
Brittany Willer
Other
Eligibility
Up to 18 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Phase 4 Interventional Results available

A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy

NCT01267136
View directory record Official record
Conditions
Tonsillitis, Pain
Interventions
Codeine with acetaminophen, Tramadol suspension
Drug
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
4 Years to 15 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 17, 2014 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Results available

Default Dosing Settings for Opioid Prescriptions to Adolescents and Young Adults After Tonsillectomy

NCT04066829
View directory record Official record
Conditions
Tonsillectomy
Interventions
Default setting intervention
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
12 Years to 25 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Results available

Preoperative Gabapentin for Post-tonsillectomy Pain in Children

NCT01707420
View directory record Official record
Conditions
Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy
Interventions
Gabapentin, liquid placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
5 Years to 16 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 15, 2021 · Synced Oct 22, 2026, 5:13 PM EDT
Recruiting Early Phase 1 Interventional

TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage: Pilot Study

NCT06580509
View directory record Official record
Conditions
Hemorrhage, Surgical, Tonsillar Bleeding
Interventions
Tranexamic Acid Injectable Product, Normal Saline
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
2 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 22, 2026, 5:13 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Caffeine in Children With Obstructive Sleep Apnea, Dose Response Study

NCT01349205
View directory record Official record
Conditions
Obstructive Sleep Apnea, Enlargement of Tonsil or Adenoid
Interventions
Caffeine and sodium Benzoate 10 mg/kg IV, Caffeine and Sodium Benzoate 20 mg/kg IV, 0.9 NS Saline
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
2 Years to 12 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 13, 2016 · Synced Oct 22, 2026, 5:13 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Measuring Pain and Hydration After Tonsillectomy

NCT02011230
View directory record Official record
Conditions
Dehydration
Interventions
Hoist Group
Other
Lead sponsor
TriHealth Inc.
Other
Eligibility
4 Years to 98 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 22, 2018 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Phase 4 Interventional

Home Care Management of Pediatric Pain

NCT00251628
View directory record Official record
Conditions
Tonsillectomy
Interventions
Standard Care, ATC Dosing, Structured Pain Management Program, As needed dosing
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years to 15 Years
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2012
U.S. locations
1
States / cities
Madera, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2012 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Duration of Antibiotic Therapy on Recovery Following Tonsillectomy

NCT00662987
View directory record Official record
Conditions
Tonsillectomy
Interventions
7 days of amoxicillin, 3 days of amoxcillin followed by 4 days of placebo
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
Up to 18 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 21, 2008 · Synced Oct 22, 2026, 5:13 PM EDT
Terminated Not applicable Interventional

iPad for Post Operative Pain After Tonsillectomy

NCT07770529
View directory record Official record
Conditions
Pain
Interventions
iPad, Intervention Control
Device · Behavioral
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
3 Years to 10 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 22, 2026, 5:13 PM EDT
Completed Phase 4 Interventional Results available

Acetaminophen's Efficacy For Post-operative Pain

NCT01721486
View directory record Official record
Conditions
Tonsillitis, Airway Obstruction, Difficulty Swallowing
Interventions
IV acetaminophen, PO acetaminophen
Drug
Lead sponsor
Kaveh Aslani, MD
Other
Eligibility
5 Years to 13 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Oct 22, 2026, 5:13 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Inferior Turbinate Reduction in Pediatric Population Failing Surgery for Sleep Disordered Breathing

NCT00936494
View directory record Official record
Conditions
Sleep Related Breathing Disorder, Upper Airway Resistance Syndrome, Obstructive Sleep Apnea
Interventions
Cold ablation inferior turbinate reduction
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
Up to 18 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Oct 22, 2026, 5:13 PM EDT