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ClinicalTrials.gov public records Last synced Oct 17, 2026, 2:17 AM EDT

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Showing 73–90 of 90 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: transcranial alternating current stimulation Clear all
Recruiting Not applicable Interventional

Transcranial Alternating Current Stimulation (tACS) for the Treatment of Anxiety in Veterans: An Open-Label Pilot Study

NCT07288008
View directory record Official record
Conditions
Anxiety
Interventions
Transcranial alternating current stimulator
Device
Lead sponsor
Birmingham VA Health Care System
Federal
Eligibility
19 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 31, 2025 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression

NCT05772702
View directory record Official record
Conditions
Depression, Major Depressive Disorder, tACS
Interventions
Closed-loop tACS
Device
Lead sponsor
Electromedical Products International, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Oct 17, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Neurosensory Account of Anxiety and Stress (Study 1)

NCT05895006
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Intrinsic and Novelty-related Sensory Cortical (SC) Disinhibition
Interventions
Alternating Current Stimulation (tACS), Sham for Transcranial Alternating Current Stimulation (tACS), Transcranial Random Noise stimulation (tRNS)
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 50 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 12, 2025 · Synced Oct 17, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional

Transcranial Stimulation Combined With Auditory Training

NCT06738030
View directory record Official record
Conditions
Difficulties Understanding Speech in Noise
Interventions
Transcranial current stimulation, Auditory training
Device · Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
50 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of Transcranial Direct Current Stimulation (tDCS) Coupled With Constraint Induced Movement Therapy in Stroke Patient

NCT01143649
View directory record Official record
Conditions
Stroke, Healthy
Interventions
transcranial direct current stimulation (tDCS), constraint induced movement therapy (CIMT), transcranial alternating current stimulation (tACS)
Device · Procedure
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 17, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional

Transcranial Alternating Current Stimulation (tACS) in Stuttering

NCT06740968
View directory record Official record
Conditions
Stuttering, Adult, Stuttering, Childhood, Stuttering, Developmental
Interventions
transcranial alternating current stimulation (tACS)
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults

NCT05523505
View directory record Official record
Conditions
Reading Disability
Interventions
Sham intervention, RLN real non-invasive brain stimulation intervention, RLN and CCN real non-invasive brain stimulation intervention
Device
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 40 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 17, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Patient-Centered NeuroRehabilitation (PCN)

NCT03036319
View directory record Official record
Conditions
Cognitive Deficit
Interventions
Active tDCS, Sham tDCS, Cognitively based intervention, Active tACS, Sham tACS, Active tRNS, Sham tRNS
Device · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Bipolar Transcranial Alternating Current Stimulation (tACS)

NCT05480124
View directory record Official record
Conditions
Bipolar Disorder
Interventions
tACS brain stimulation treatment, Sham stimulation treatment
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 55 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Oct 17, 2026, 2:17 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Mid-frontal Delta/Theta and Cognitive Control

NCT06984757
View directory record Official record
Conditions
Parkinson&Amp;Amp;#39;s Disease (PD)
Interventions
Deep-brain Stimulation, Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation
Device
Lead sponsor
Nandakumar Narayanan
Other
Eligibility
18 Years to 99 Years
Enrollment
635 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2029
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neurophysiologic Signatures of Trigeminal Neuralgia Pain

NCT03778177
View directory record Official record
Conditions
Trigeminal Neuralgia (TN)
Interventions
transcranial electrical brain stimulation
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 6, 2022 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

At-home Transcranial Alternating Current Stimulation During Multitasking

NCT04231825
View directory record Official record
Conditions
Multitasking Behavior
Interventions
Transcranial alternating current stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 35 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

tACS for Amyloid-β Reduction in Alzheimer's Disease

NCT03290326
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Transcranial Alternating Current Stimulation (tACS)
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
45 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 22, 2022 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Transcranial Magnetic Stimulation (TMS) and Stimulus Controllability on Pain Perception

NCT01030133
View directory record Official record
Conditions
Chronic Pain
Interventions
Operator Role Real TMS, Receiver Role Real TMS, Operator Role Sham TMS, Receiver Role Sham TMS, All Participants Operator Role
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 28, 2018 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia

NCT05084924
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia
Interventions
Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Oct 17, 2026, 2:17 AM EDT
Active, not recruiting Phase 2 Interventional

Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment

NCT07097051
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
real tACS, sham tACS
Other
Lead sponsor
High Point University
Other
Eligibility
65 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 17, 2026, 2:17 AM EDT
Enrolling by invitation Not applicable Interventional

Electrical Stimulation of the Optic Nerve in Patients With Glaucoma.

NCT06693882
View directory record Official record
Conditions
Glaucoma
Interventions
EYETRONIC Nextwave System
Device
Lead sponsor
Glaucoma Center of San Francisco
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Oct 17, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Mechanism of Action of tACS for the Treatment of MDD

NCT03994081
View directory record Official record
Conditions
Major Depressive Disorder, MDD
Interventions
tACS, Sham tACS
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 17, 2026, 2:17 AM EDT